Search Results - "BACHE, Matthias"

Mitochondria-Targeting 1,5-Diazacyclooctane-Spacered Triterpene Rhodamine Conjugates Exhibit Cytotoxicity at Sub-Nanomolar Concentration against Breast Cancer Cells by Heise, Niels, Becker, Selina, Mueller, Thomas, Bache, Matthias, Csuk, René, Güttler, Antje

“…1,5-Diazacyclooctane was prepared by a simple synthetic sequence and coupled to pentacyclic triterpenoic acids oleanolic acid, ursolic acid, betulinic acid,…”
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Dynamics of Heat Shock Protein 70 Serum Levels As a Predictor of Clinical Response in Non-Small-Cell Lung Cancer and Correlation with the Hypoxia-Related Marker Osteopontin by Ostheimer, Christian, Gunther, Sophie, Bache, Matthias, Vordermark, Dirk, Multhoff, Gabriele

“…Hypoxia mediates resistance to radio(chemo)therapy (RT) by stimulating the synthesis of hypoxia-related genes, such as osteopontin (OPN) and stress proteins,…”
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Betulin Sulfonamides as Carbonic Anhydrase Inhibitors and Anticancer Agents in Breast Cancer Cells by Güttler, Antje, Eiselt, Yvonne, Funtan, Anne, Thiel, Andreas, Petrenko, Marina, Keßler, Jacqueline, Thondorf, Iris, Paschke, Reinhard, Vordermark, Dirk, Bache, Matthias

“…Hypoxia-regulated protein carbonic anhydrase IX (CA IX) is up-regulated in different tumor entities and correlated with poor prognosis in breast cancer…”
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Correlation between Circulating miR-16, miR-29a, miR-144 and miR-150, and the Radiotherapy Response and Survival of Non-Small-Cell Lung Cancer Patients by Bache, Matthias, Kadler, Frauke, Struck, Olivia, Medenwald, Daniel, Ostheimer, Christian, Güttler, Antje, Keßler, Jacqueline, Kappler, Matthias, Riemann, Anne, Thews, Oliver, Seliger, Barbara, Vordermark, Dirk

“…Despite the success of current therapy concepts, patients with advanced non-small-cell lung cancer (NSCLC) still have a very poor prognosis. Therefore,…”
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HIF-1α inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression by Kessler, Jacqueline, Hahnel, Antje, Wichmann, Henri, Rot, Swetlana, Kappler, Matthias, Bache, Matthias, Vordermark, Dirk

“…Hypoxia induces activation of the HIF-1 pathway and is an essential characteristic of malignant gliomas. Hypoxia has been linked to tumor progression, therapy…”
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Investigation of the Prognostic Role of Carbonic Anhydrase 9 (CAIX) of the Cellular mRNA/Protein Level or Soluble CAIX Protein in Patients with Oral Squamous Cell Carcinoma by Eckert, Alexander W, Horter, Susanne, Bethmann, Daniel, Kotrba, Johanna, Kaune, Tom, Rot, Swetlana, Bache, Matthias, Bilkenroth, Udo, Reich, Waldemar, Greither, Thomas, Wickenhauser, Claudia, Vordermark, Dirk, Taubert, Helge, Kappler, Matthias

“…s Carbonic anhydrase 9 (CAIX) is an important protein that stabilizes the extracellular pH value and is transcriptionally regulated by hypoxia-inducible factor…”
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Causes and Consequences of A Glutamine Induced Normoxic HIF1 Activity for the Tumor Metabolism by Kappler, Matthias, Pabst, Ulrike, Weinholdt, Claus, Taubert, Helge, Rot, Swetlana, Kaune, Tom, Kotrba, Johanna, Porsch, Martin, Güttler, Antje, Bache, Matthias, Krohn, Knut, Bull, Fabian, Riemann, Anne, Wickenhauser, Claudia, Seliger, Barbara, Schubert, Johannes, Al-Nawas, Bilal, Thews, Oliver, Grosse, Ivo, Vordermark, Dirk, Eckert, Alexander W

“…The transcription factor hypoxia-inducible factor 1 (HIF1) is the crucial regulator of genes that are involved in metabolism under hypoxic conditions, but…”
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Combination of Betulinic Acid Fragments and Carbonic Anhydrase Inhibitors-A New Drug Targeting Approach by Bache, Matthias, Heise, Niels V, Thiel, Andreas, Funtan, Anne, Seifert, Franziska, Petrenko, Marina, Güttler, Antje, Brandt, Sarah, Mueller, Thomas, Vordermark, Dirk, Thondorf, Iris, Csuk, René, Paschke, Reinhard

“…Human carbonic anhydrase IX (hCA IX) is a zinc(II)-dependent metalloenzyme that plays a critical role in the conversion of carbon dioxide and water to protons…”
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Betulinyl Sulfamates as Anticancer Agents and Radiosensitizers in Human Breast Cancer Cells by Bache, Matthias, Münch, Christin, Güttler, Antje, Wichmann, Henri, Theuerkorn, Katharina, Emmerich, Daniel, Paschke, Reinhard, Vordermark, Dirk

“…Betulinic acid (BA), a natural compound of birch bark, is cytotoxic for many tumors. Recently, a betulinyl sulfamate was described that inhibits carbonic…”
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The Impact of Non-Lethal Single-Dose Radiation on Tumor Invasion and Cytoskeletal Properties by Hohmann, Tim, Grabiec, Urszula, Vogel, Carolin, Ghadban, Chalid, Ensminger, Stephan, Bache, Matthias, Vordermark, Dirk, Dehghani, Faramarz

“…Irradiation is the standard therapy for glioblastoma multiforme. Glioblastoma are highly resistant to radiotherapy and the underlying mechanisms remain…”
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Low HIF-1α and low EGFR mRNA Expression Significantly Associate with Poor Survival in Soft Tissue Sarcoma Patients; the Proteins React Differently by Rot, Swetlana, Taubert, Helge, Bache, Matthias, Greither, Thomas, Würl, Peter, Holzhausen, Hans-Jürgen, Eckert, Alexander W, Vordermark, Dirk, Kappler, Matthias

“…In various tumors, the hypoxia inducible factor-1α ( ) and the epidermal growth factor-receptor ( ) have an impact on survival. Nevertheless, the prognostic…”
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Plasma β‐synuclein, GFAP , and neurofilaments in patients with malignant gliomas undergoing surgical and adjuvant therapy by Abu-Rumeileh, Samir, Barba, Lorenzo, Bache, Matthias, Halbgebauer, Steffen, Oeckl, Patrick, Steinacker, Petra, Güttler, Antje, Keßler, Jacqueline, Illert, Jörg, Strauss, Christian, Vordermark, Dirk, Otto, Markus

“…We analyzed the longitudinal concentrations and prognostic roles of plasma β‐synuclein (β‐syn), glial fibrillary acidic protein (GFAP), and neurofilament…”
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Prognostic impact of mRNA levels of LGR5 transcript variants in OSCC patients by Rot, Swetlana, Kaune, Tom, Taubert, Helge, Greither, Thomas, Kotrba, Johanna, Güttler, Antje, Wichmann, Henri, Bilkenroth, Udo, Wienke, Andreas, Al-Nawas, Bilal, Bache, Matthias, Vordermark, Dirk, Wickenhauser, Claudia, Bethmann, Daniel, Eckert, Alexander W, Kappler, Matthias

“…The human leucine-rich, repeat-containing G protein-coupled receptor 5 (LGR5) is a stem cell marker in numerous adult tissues and is overexpressed in a large…”
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GP88/PGRN Serum Levels Are Associated with Prognosis for Oral Squamous Cell Carcinoma Patients by Greither, Thomas, Steiner, Tina, Bache, Matthias, Serrero, Ginette, Otto, Sven, Taubert, Helge, Eckert, Alexander W., Kappler, Matthias

“…Progranulin (PGRN)/GP88 is a growth factor that is expressed in a wide range of tumor tissues. The secreted form is involved in various biological processes…”
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CMG2 Expression Is an Independent Prognostic Factor for Soft Tissue Sarcoma Patients by Greither, Thomas, Wedler, Alice, Rot, Swetlana, Keßler, Jacqueline, Kehlen, Astrid, Holzhausen, Hans-Jürgen, Bache, Matthias, Würl, Peter, Taubert, Helge, Kappler, Matthias

“…The capillary morphogenesis gene 2 (CMG2), also known as the anthrax toxin receptor 2 (ANTXR2), is a transmembrane protein putatively involved in extracellular…”
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Betulinic acid derivatives NVX-207 and B10 for treatment of glioblastoma--an in vitro study of cytotoxicity and radiosensitization by Bache, Matthias, Bernhardt, Stephan, Passin, Sarina, Wichmann, Henri, Hein, Anja, Zschornak, Martin, Kappler, Matthias, Taubert, Helge, Paschke, Reinhard, Vordermark, Dirk

“…Betulinic acid (BA), a pentacyclic triterpene, represents a new therapeutic substance that has potential benefits for treating glioblastoma. Recently, new…”
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Sialic acid metabolic engineering: a potential strategy for the neuroblastoma therapy by Gnanapragassam, Vinayaga S, Bork, Kaya, Galuska, Christina E, Galuska, Sebastian P, Glanz, Dagobert, Nagasundaram, Manimozhi, Bache, Matthias, Vordermark, Dirk, Kohla, Guido, Kannicht, Christoph, Schauer, Roland, Horstkorte, Rüdiger

“…Sialic acids (Sia) represent negative-charged terminal sugars on most glycoproteins and glycolipids on the cell surface of vertebrates. Aberrant expression of…”
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SESN2 Knockdown Increases Betulinic Acid-Induced Radiosensitivity of Hypoxic Breast Cancer Cells by Güttler, Antje, Weinholdt, Claus, Ruff, Elisabeth, Reidt, Judith, Darnstaedt, Elisa, Wildemann, Alicia, Petrenko, Marina, Keßler, Jacqueline, Kappler, Matthias, Grosse, Ivo, Vordermark, Dirk, Bache, Matthias

“…Betulinic acid (BA) is a natural compound well known for its anti-inflammatory, anti-viral, anti-bacterial, anti-malarial effects and anti-tumor properties…”
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Effects of osteopontin inhibition on radiosensitivityof MDA-MB-231 breast cancer cells by Hahnel, Antje, Wichmann, Henri, Kappler, Matthias, Kotzsch, Matthias, Vordermark, Dirk, Taubert, Helge, Bache, Matthias

“…Abstract Background Osteopontin (OPN) is a secreted glycophosphoprotein that is overexpressed in various tumors, and high levels of OPN have been associated…”
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Correction: Sialic Acid Metabolic Engineering: A Potential Strategy for the Neuroblastoma Therapy by Gnanapragassam, Vinayaga S, Bork, Kaya, Galuska, Christina E, Galuska, Sebastian P, Glanz, Dagobert, Nagasundaram, Manimozhi, Bache, Matthias, Vordermark, Dirk, Kohla, Guido, Kannicht, Christoph, Schauer, Roland, Horstkorte, Rüdiger

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