Search Results - "BAAK, Jan"
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Major bioactive chemical compounds in Astragali Radix samples from different vendors vary greatly
Published in PloS one (07-07-2021)“…The worldwide traditional Chinese medicine (TCM) herbs sales figures have increased considerably to 50 billion US$ (2018). Astragali Radix (AR) is amongst the…”
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Proliferation and immunohistochemistry for p53, CD25 and CK20 in predicting prognosis of non-muscle invasive papillary urothelial carcinomas
Published in PloS one (26-01-2024)“…Non-muscle invasive papillary urothelial carcinoma is a prevalent disease with a high recurrence tendency. Good prognostic and reproducible biomarkers for…”
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Supersaturation and Precipitation Applicated in Drug Delivery Systems: Development Strategies and Evaluation Approaches
Published in Molecules (Basel, Switzerland) (27-02-2023)“…Supersaturation is a promising strategy to improve gastrointestinal absorption of poorly water-soluble drugs. Supersaturation is a metastable state and…”
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Network pharmacology analysis of the therapeutic mechanisms of the traditional Chinese herbal formula Lian Hua Qing Wen in Corona virus disease 2019 (COVID-19), gives fundamental support to the clinical use of LHQW
Published in Phytomedicine (Stuttgart) (01-12-2020)“…The traditional Chinese Medicine (TCM) herbal formula Lian Hua Qing Wen (LHQW) improves the results of COVID-19 treatment. Three very recent studies analyzed…”
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Mitotic activity index and CD25+ lymphocytes predict risk of stage progression in non-muscle invasive bladder cancer
Published in PloS one (02-06-2020)“…In urothelial cell type non-muscle invasive urinary bladder carcinoma, TNM stage and WHO grade are widely used to classify patients into low and high-risk…”
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Comparison of the effect of different techniques for measurement of Ki67 proliferation on reproducibility and prognosis prediction accuracy in breast cancer
Published in Histopathology (01-12-2012)“…Gudlaugsson E, Skaland I, Janssen E A M, Smaaland R, Shao Z, Malpica A, Voorhorst F & Baak J P A (2012) Histopathology Comparison of the effect of different…”
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Validation study of MARCKSL1 as a prognostic factor in lymph node-negative breast cancer patients
Published in PloS one (11-03-2019)“…Protein expression of Myristoylated alanine-rich C kinase substrate like-1 (MARCKSL1) has been identified as a prognostic factor in lymph-node negative (LN-)…”
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In stage IV pulmonary adenocarcinoma patients, treatment with Traditional Chinese Medicine alone gives prognostically superior results to treatment with Platinum-Based Chemotherapy alone
Published in Phytomedicine (Stuttgart) (01-12-2023)“…•Thirty % of stage IV adenocarcinomas die before 3 months. Patients with >3 months survival, have a much better survival.•Methodological flaws from other stage…”
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Validation of expression patterns for nine miRNAs in 204 lymph-node negative breast cancers
Published in PloS one (07-11-2012)“…Although lymph node negative (LN-) breast cancer patients have a good 10-years survival (∼85%), most of them still receive adjuvant therapy, while only some…”
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Reproducibility and prognostic value of WHO1973 and WHO2004 grading systems in TaT1 urothelial carcinoma of the urinary bladder
Published in PloS one (07-01-2014)“…European treatment guidelines of TaT1 urinary bladder urothelial carcinomas depend highly on stage and WHO1973-grade but grading reproducibility is wanting…”
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MiR-18a and miR-18b are expressed in the stroma of oestrogen receptor alpha negative breast cancers
Published in BMC cancer (05-05-2020)“…Previously, we have shown that miR-18a and miR-18b gene expression strongly correlates with high proliferation, oestrogen receptor -negativity (ER ),…”
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Clinical and Biological Interpretation of Survival Curves of Cancer Patients, Exemplified With Stage IV Non-Small Cell Lung Cancers With Long Follow-up
Published in Frontiers in oncology (02-02-2022)“…Worldwide, 18.1 million new invasive cancers and 9.9 million cancer deaths occurred in 2020. Lung cancer is the second most frequent (11.4%) and, with 1.8…”
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Automated Prognostic Assessment of Endometrial Hyperplasia for Progression Risk Evaluation Using Artificial Intelligence
Published in Modern pathology (01-05-2023)“…Endometrial hyperplasia is a precursor to endometrial cancer, characterized by excessive proliferation of glands that is distinguishable from normal…”
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The Ki67 dilemma: investigating prognostic cut-offs and reproducibility for automated Ki67 scoring in breast cancer
Published in Breast cancer research and treatment (01-08-2024)“…Purpose Quantification of Ki67 in breast cancer is a well-established prognostic and predictive marker, but inter-laboratory variability has hampered its…”
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"How Long Have I Got?" in Stage IV NSCLC Patients With at Least 3 Months Up to 10 Years Survival, Accuracy of Long-, Intermediate-, and Short-Term Survival Prediction Is Not Good Enough to Answer This Question
Published in Frontiers in oncology (21-12-2021)“…Most lung cancer patients worldwide [stage IV nonsmall cell lung cancer (NSCLC)] have a poor survival: 25%-30% die <3 months. Yet, of those surviving…”
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Metabolic consequences of perioperative oral carbohydrates in breast cancer patients - an explorative study
Published in BMC cancer (04-12-2019)“…The metabolic consequences of preoperative carbohydrate load in breast cancer patients are not known. The present explorative study investigated the systemic…”
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Prognostic value of gene signatures and proliferation in lymph-node-negative breast cancer
Published in PloS one (05-03-2014)“…The overall survival rate is good for lymph-node-negative breast cancer patients, but they still suffer from serious over- and some undertreatments. Prognostic…”
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Factors that influence persistence or recurrence of high-grade squamous intraepithelial lesion with positive margins after the loop electrosurgical excision procedure: a retrospective study
Published in BMC cancer (20-10-2015)“…In 5-20 % of patients with cervical high-grade squamous intraepithelial lesion (HSIL), a positive margin after the loop electrosurgical excision procedure…”
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Can proliferation biomarkers reliably predict recurrence in World Health Organization 2003 defined endometrial stromal sarcoma, low grade?
Published in PloS one (11-10-2013)“…An estimated 1500-3000 invasive Endometrial Stromal Sarcomas (ESS) cases annually occur worldwide. Before 2003, ESS was divided as low and high grade ESS based…”
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Influence of pre-operative oral carbohydrate loading vs. standard fasting on tumor proliferation and clinical outcome in breast cancer patients ─ a randomized trial
Published in BMC cancer (08-11-2019)“…Conflicting results have been reported on the influence of carbohydrates in breast cancer. To determine the influence of pre-operative per-oral carbohydrate…”
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