Search Results - "B T Kinsella"

Thromboxane A2 signalling in humans: a 'Tail' of two receptors by Kinsella, B T

“…Since its discovery in 1975, we now have a wealth of knowledge relating to the biochemical, pharmacological and physiological actions of thromboxane A(2)…”
Get more information

Purification and characterization of Rac 2. A cytosolic GTP-binding protein that regulates human neutrophil NADPH oxidase by KNAUS, U. G, HEYWORTH, P. G, KINSELLA, B. T, CURNUTTE, J. T, BOKOCH, G. M

“…Human neutrophils and other phagocytes generate superoxide anion (O2-) as a means of destroying ingested microorganisms. O2- is produced by an NADPH-consuming…”
Get full text

Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA by KINSELLA, B. T, ERDMAN, R. A, MALTESE, W. A

“…Membrane localization of p21ras is dependent upon its posttranslational modification by a 15-carbon farnesyl group. The isoprenoid is linked to a cysteine…”
Get full text

Posttranslational Modification of Ha-ras p21 by Farnesyl Versus Geranylgeranyl Isoprenoids is Determined by the COOH-Terminal Amino Acid by Kinsella, B. Therese, Erdman, Robert A., Maltese, William A.

“…ras proteins undergo posttranslational modification by a 15-carbon farnesyl isoprenoid at a cysteine within a defined COOH-terminal amino acid motif; i.e.,…”
Get full text

rab GTP-binding proteins implicated in vesicular transport are isoprenylated in vitro at cysteines within a novel carboxyl-terminal motif by KINSELLA, B. T, MALTESE, W. A

“…Low molecular mass GTP-binding proteins encoded by the mammalian rab genes are found in membranes of the Golgi complex and endosomes, suggesting that they play…”
Get full text

The effects of the statins lovastatin and cerivastatin on signalling by the prostanoid IP‐receptor by Lawler, Orlaith A, Miggin, Sinead M, Kinsella, B Therese

“…The prostanoid‐IP receptor may be unique among G protein coupled receptors in that it is isoprenylated. In this study, we investigated the effects of the…”
Get full text

Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(s)-, to G(i)-, and to G(q)-coupled effector signaling by Lawler, O A, Miggin, S M, Kinsella, B T

“…The prostacyclin receptor (IP) is primarily coupled to G alpha(s)-dependent activation of adenylyl cyclase; however, a number of studies indicate that the IP…”
Get full text

Thromboxane A(2) receptor mediated activation of the mitogen activated protein kinase cascades in human uterine smooth muscle cells by Miggin, S M, Kinsella, B T

“…Both thromboxane (TX) A(2) and 8-epi prostaglandin (PG) F(2alpha) have been reported to stimulate mitogenesis of vascular smooth muscle (SM) in a number of…”
Get more information

The thromboxane receptor antagonist NTP42 improves haemodynamics, inhibits remodelling, and restores function within the cardiopulmonary system in preclinical pulmonary arterial hypertension models by Kinsella, B T, Mulvaney, E, Renzo, F

Get full text

Investigation of the role of the carboxyl-terminal tails of the alpha and beta isoforms of the human thromboxane A(2) receptor (TP) in mediating receptor:effector coupling by Walsh, M, Foley, J F, Kinsella, B T

“…We have investigated the functional coupling of alpha and beta isoforms of the human thromboxane A(2) receptor (TP) to Galpha(16) and Galpha(12) members of the…”
Get more information

rab GTP-binding proteins with three different carboxyl-terminal cysteine motifs are modified in vivo by 20-carbon isoprenoids by THERESE KINSELLA, B, MALTESE, W. A

“…p21ras and several other ras-related GTP-binding proteins are modified post-translationally by addition of 15-carbon farnesyl or 20-carbon geranylgeranyl…”
Get full text

The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling by Hayes, J S, Lawler, O A, Walsh, M T, Kinsella, B T

“…The prostacyclin receptor (IP), a G protein-coupled receptor, mediates the actions of the prostanoid prostacyclin and its mimetics. IPs from a number of…”
Get full text

Molecular cloning and characterization of a Candida tsukubaensis alpha-glucosidase gene in the yeast Saccharomyces cerevisiae by Kinsella, B.T. (Guinness Brewing Worldwide Research Centre, Dublin (Ireland)), Larkin, A, Bolton, M, Cantwell, B.A

“…The molecular cloning of an alpha-glucosidase gene isolated from a Candida tsukubaensis (CBS 6389) genomic library in Saccharomyces cervisiae is reported. The…”
Get full text

Regulation of the human prostanoid TPα and TPβ receptor isoforms mediated through activation of the EP1 and IP receptors by Walsh, Marie‐Therese, Kinsella, B Therese

“…The intermolecular cross‐regulation mediated by the prostanoid IP‐receptor (IP)/EP1 receptor (EP1) agonists PGI2 and 17 phenyl trinor PGE2 on TP receptor (TP)…”
Get full text

Analysis of the expression and secretion of the Candida tsukubaensis alpha-glucosidase gene in the yeast Saccharomyces cerevisiae by Kinsella, B T, Cantwell, B A

“…The alpha-glucosidase gene of Candida tsukubaensis is contained within a 3.47 kb BamH1-Mlul fragment which, when introduced into Saccharomyces cerevisiae AH22…”
Get more information

Phosphorylation and regulated expression of the human thromboxane A2 receptor by B T Kinsella, D J O'Mahony, G A FitzGerald

“…Recombinant forms of the human thromboxane A2 (TXA2) receptor composed of the carboxyl-terminal amino acid residues 220-343 were phosphorylated in vitro by…”
Get full text

Estrogen Increases Expression of the Human Prostacyclin Receptor within the Vasculature through an ERα-Dependent Mechanism by Turner, Elizebeth C., Kinsella, B. Therese

“…Prostacyclin and the prostacyclin receptor (IP) are implicated in mediating many of the atheroprotective effects of estrogen in both humans and in animal…”
Get full text

Primary structure and processing of the Candida tsukubaensis α-glucosidase : homology with the rabbit intestinal sucrase-isomaltase complex and human lysosomal α-glucosidase by KINSELLA, B. T, HOGAN, S, LARIN, A, CANTWELL, B. A

“…The nucleotide sequence of a 4.39-kb DNA fragment encoding the alpha-glucosidase gene of Candida tsukubaensis is reported. The cloned gene contains a major…”
Get full text

Transcription from the rat 45S ribosomal DNA promoter does not require the factor UBF by Smith, S. David, O'Mahony, Daniel J., Kinsella, B. Therese, Rothblum, Lawrence I.

“…For efficient transcription from the rat ribosomal DNA (rDNA) promoter by RNA polymerase I in vitro, at least two transcription factors, rat UBF and rat SL-1,…”
Get full text

Transcriptional Regulation of the Human Prostacyclin Receptor Gene Is Dependent on Sp1, PU.1 and Oct-1 in Megakaryocytes and Endothelial Cells by Turner, Elizebeth C., Kinsella, B. Therese

“…Prostacyclin plays a central role in hemostasis, inflammation and nociception. However, the factors regulating expression of the prostacyclin receptor (IP)…”
Get full text