Search Results - "Bürger, Iris"
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Automated manufacturing and characterization of clinical grade autologous CD20 CAR T cells for the treatment of patients with stage III/IV melanoma
Published in Frontiers in immunology (25-09-2024)“…Point-of-care (POC) manufacturing of chimeric antigen receptor (CAR) modified T cell has expanded rapidly over the last decade. In addition to the use of CD19…”
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Anti-CD19 CARs displayed at the surface of lentiviral vector particles promote transduction of target-expressing cells
Published in Molecular therapy. Methods & clinical development (11-06-2021)“…Recently, a rare type of relapse was reported upon treating a B cell acute lymphoblastic leukemia (B-ALL) patient with anti-CD19 chimeric antigen receptor…”
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Culture expansion of CAR T cells results in aberrant DNA methylation that is associated with adverse clinical outcome
Published in Leukemia (01-09-2023)“…Chimeric antigen receptor (CAR) T cells provide new perspectives for treatment of hematological malignancies. Manufacturing of these cellular products includes…”
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A Phase I Dose Finding Trial of MB-CART20.1 in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma
Published in Blood (15-11-2022)Get full text
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Trial in Progress: A Randomized Phase II Study of MB-CART2019.1 Compared to Standard of Care Therapy in Patients with Relapsed/Refractory DLBCL Ineligible for High-Dose Chemotherapy and Autologous Stem Cell Transplantation - DALY 2-EU Trial
Published in Blood (15-11-2022)Get full text
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Functionality and Cell Senescence of CD4/ CD8-Selected CD20 CAR T Cells Manufactured Using the Automated CliniMACS Prodigy® Platform
Published in Transfusion medicine and hemotherapy (01-02-2019)“…Clinical studies using autologous CAR T cells have achieved spectacular remissions in refractory CD19+ B cell leukaemia, however some of the patient treatments…”
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Phase I Trial of MB-CART2019.1, a Novel CD20 and CD19 Targeting Tandem Chimeric Antigen Receptor, in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma
Published in Blood (05-11-2020)“…Background CD19 redirected chimeric antigen receptor (CAR) T-cell therapy has proven efficacy in relapsed or chemotherapy-refractory (r/r) aggressive B-cell…”
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A mono phenylalanine-based motif (F 790) and a leucine-dependent motif (LI 760) mediate internalization of furin
Published in European journal of cell biology (01-03-1999)“…The eukaryotic endoprotease furin, a member of the subtilisin-related family of prohormone convertases, is synthesized and transported within the constitutive…”
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Workshop on statistical modelling of discrete data and structures
Published in Computational statistics & data analysis (01-05-1996)Get full text
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