Search Results - "Bülow, Roman"

DNA-binding protein-A: a multitool in tubular epithelial cells by Droste, Patrick, Boor, Peter, Bülow, Roman D

“…Acute kidney injury is still associated with high morbidity and mortality. Reichardt et al. investigated DNA-binding protein-A (Ybx3) in acute kidney injury…”
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Deep Learning-Based Segmentation and Quantification in Experimental Kidney Histopathology by Bouteldja, Nassim, Klinkhammer, Barbara M, Bülow, Roman D, Droste, Patrick, Otten, Simon W, Freifrau von Stillfried, Saskia, Moellmann, Julia, Sheehan, Susan M, Korstanje, Ron, Menzel, Sylvia, Bankhead, Peter, Mietsch, Matthias, Drummer, Charis, Lehrke, Michael, Kramann, Rafael, Floege, Jürgen, Boor, Peter, Merhof, Dorit

“…Nephropathologic analyses provide important outcomes-related data in experiments with the animal models that are essential for understanding kidney disease…”
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Extracellular Matrix in Kidney Fibrosis: More Than Just a Scaffold by Bülow, Roman David, Boor, Peter

“…Kidney fibrosis is the common histological end-point of progressive, chronic kidney diseases (CKDs) regardless of the underlying etiology. The hallmark of…”
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Multistain segmentation of renal histology: first steps toward artificial intelligence-augmented digital nephropathology by Bülow, Roman D, Kers, Jesper, Boor, Peter

“…Artificial intelligence (AI), and particularly deep learning (DL), are showing great potential in improving pathology diagnostics in many aspects, 1 of which…”
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Complement activation induces excessive T cell cytotoxicity in severe COVID-19 by Georg, Philipp, Astaburuaga-García, Rosario, Bonaguro, Lorenzo, Brumhard, Sophia, Michalick, Laura, Lippert, Lena J., Kostevc, Tomislav, Gäbel, Christiane, Schneider, Maria, Streitz, Mathias, Demichev, Vadim, Gemünd, Ioanna, Barone, Matthias, Tober-Lau, Pinkus, Helbig, Elisa T., Hillus, David, Petrov, Lev, Stein, Julia, Dey, Hannah-Philine, Paclik, Daniela, Iwert, Christina, Mülleder, Michael, Aulakh, Simran Kaur, Djudjaj, Sonja, Bülow, Roman D., Mei, Henrik E., Schulz, Axel R., Thiel, Andreas, Hippenstiel, Stefan, Saliba, Antoine-Emmanuel, Eils, Roland, Lehmann, Irina, Mall, Marcus A., Stricker, Sebastian, Röhmel, Jobst, Corman, Victor M., Beule, Dieter, Wyler, Emanuel, Landthaler, Markus, Obermayer, Benedikt, von Stillfried, Saskia, Boor, Peter, Demir, Münevver, Wesselmann, Hans, Suttorp, Norbert, Uhrig, Alexander, Müller-Redetzky, Holger, Nattermann, Jacob, Kuebler, Wolfgang M., Meisel, Christian, Ralser, Markus, Schultze, Joachim L., Aschenbrenner, Anna C., Thibeault, Charlotte, Kurth, Florian, Sander, Leif E., Blüthgen, Nils, Sawitzki, Birgit

“…Severe COVID-19 is linked to both dysfunctional immune response and unrestrained immunopathology, and it remains unclear whether T cells contribute to disease…”
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Decoding pathology: the role of computational pathology in research and diagnostics by Hölscher, David L, Bülow, Roman D

“…Traditional histopathology, characterized by manual quantifications and assessments, faces challenges such as low-throughput and inter-observer variability…”
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Next-Generation Morphometry for pathomics-data mining in histopathology by Hölscher, David L., Bouteldja, Nassim, Joodaki, Mehdi, Russo, Maria L., Lan, Yu-Chia, Sadr, Alireza Vafaei, Cheng, Mingbo, Tesar, Vladimir, Stillfried, Saskia V., Klinkhammer, Barbara M., Barratt, Jonathan, Floege, Jürgen, Roberts, Ian S. D., Coppo, Rosanna, Costa, Ivan G., Bülow, Roman D., Boor, Peter

“…Pathology diagnostics relies on the assessment of morphology by trained experts, which remains subjective and qualitative. Here we developed a framework for…”
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Deep learning-based classification of kidney transplant pathology: a retrospective, multicentre, proof-of-concept study by Kers, Jesper, Bülow, Roman D, Klinkhammer, Barbara M, Breimer, Gerben E, Fontana, Francesco, Abiola, Adeyemi Adefidipe, Hofstraat, Rianne, Corthals, Garry L, Peters-Sengers, Hessel, Djudjaj, Sonja, von Stillfried, Saskia, Hölscher, David L, Pieters, Tobias T, van Zuilen, Arjan D, Bemelman, Frederike J, Nurmohamed, Azam S, Naesens, Maarten, Roelofs, Joris J T H, Florquin, Sandrine, Floege, Jürgen, Nguyen, Tri Q, Kather, Jakob N, Boor, Peter

“…Histopathological assessment of transplant biopsies is currently the standard method to diagnose allograft rejection and can help guide patient management, but…”
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Vascular neutrophilic inflammation and immunothrombosis distinguish severe COVID‐19 from influenza pneumonia by Nicolai, Leo, Leunig, Alexander, Brambs, Sophia, Kaiser, Rainer, Joppich, Markus, Hoffknecht, Marie‐Louise, Gold, Christoph, Engel, Anouk, Polewka, Vivien, Muenchhoff, Maximilian, Hellmuth, Johannes C., Ruhle, Adrian, Ledderose, Stephan, Weinberger, Tobias, Schulz, Heiko, Scherer, Clemens, Rudelius, Martina, Zoller, Michael, Keppler, Oliver T., Zwißler, Bernhard, Bergwelt‐Baildon, Michael, Kääb, Stefan, Zimmer, Ralf, Bülow, Roman D., Stillfried, Saskia, Boor, Peter, Massberg, Steffen, Pekayvaz, Kami, Stark, Konstantin

“…Objective Infection with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) can lead to severe pneumonia, but also thrombotic complications and…”
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Keratins are novel markers of renal epithelial cell injury by Djudjaj, Sonja, Papasotiriou, Marios, Bülow, Roman D, Wagnerova, Alexandra, Lindenmeyer, Maja T, Cohen, Clemens D, Strnad, Pavel, Goumenos, Dimitrios S, Floege, Jürgen, Boor, Peter

“…Keratins, the intermediate filaments of the epithelial cell cytoskeleton, are up-regulated and post-translationally modified in stress situations. Renal…”
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tRigon: an R package and Shiny App for integrative (path-)omics data analysis by Hölscher, David L, Goedertier, Michael, Klinkhammer, Barbara M, Droste, Patrick, Costa, Ivan G, Boor, Peter, Bülow, Roman D

“…Pathomics facilitates automated, reproducible and precise histopathology analysis and morphological phenotyping. Similar to molecular omics, pathomics datasets…”
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Finerenone Added to RAS/SGLT2 Blockade for CKD in Alport Syndrome. Results of a Randomized Controlled Trial with Col4a3-/- Mice by Zhu, Zhihui, Rosenkranz, Karoline A T, Kusunoki, Yoshihiro, Li, Chenyu, Klaus, Martin, Gross, Oliver, Angelotti, Maria-Lucia, Antonelli, Giulia, Cirillo, Luigi, Romagnani, Paola, Bouteldja, Nassim, Sadr, Alireza Vafaei, Bülow, Roman D, Boor, Peter, Anders, Hans-Joachim

“…We hypothesized that triple therapy with inhibitors of the renin-angiotensin system (RAS), sodium-glucose transporter (SGLT)-2, and the mineralocorticoid…”
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Detection of PatIent-Level distances from single cell genomics and pathomics data with Optimal Transport (PILOT) by Joodaki, Mehdi, Shaigan, Mina, Parra, Victor, Bülow, Roman D, Kuppe, Christoph, Hölscher, David L, Cheng, Mingbo, Nagai, James S, Goedertier, Michaël, Bouteldja, Nassim, Tesar, Vladimir, Barratt, Jonathan, Roberts, Ian SD, Coppo, Rosanna, Kramann, Rafael, Boor, Peter, Costa, Ivan G

“…Although clinical applications represent the next challenge in single-cell genomics and digital pathology, we still lack computational methods to analyze…”
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Banff Digital Pathology Working Group: Image Bank, Artificial Intelligence Algorithm, and Challenge Trial Developments by Farris, Alton B, Alexander, Mariam P, Balis, Ulysses G J, Barisoni, Laura, Boor, Peter, Bülow, Roman D, Cornell, Lynn D, Demetris, Anthony J, Farkash, Evan, Hermsen, Meyke, Hogan, Julien, Kain, Renate, Kers, Jesper, Kong, Jun, Levenson, Richard M, Loupy, Alexandre, Naesens, Maarten, Sarder, Pinaki, Tomaszewski, John E, van der Laak, Jeroen, van Midden, Dominique, Yagi, Yukako, Solez, Kim

“…The Banff Digital Pathology Working Group (DPWG) was established with the goal to establish a digital pathology repository; develop, validate, and share models…”
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Extending the landscape of omics technologies by pathomics by Bülow, Roman D., Hölscher, David L., Costa, Ivan G., Boor, Peter

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Activation of Notch3 in Renal Tubular Cells Leads to Progressive Cystic Kidney Disease by Djudjaj, Sonja, Kavvadas, Panagiotis, Prakoura, Niki, Bülow, Roman D, Migeon, Tiffany, Placier, Sandrine, Chadjichristos, Christos E, Boor, Peter, Chatziantoniou, Christos

“…Polycystic kidney disease (PKD) is a genetic disorder affecting millions of people worldwide that is characterized by fluid-filled cysts and leads to end-stage…”
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Multisystemic Cellular Tropism of SARS-CoV-2 in Autopsies of COVID-19 Patients by Wong, Dickson W L, Klinkhammer, Barbara M, Djudjaj, Sonja, Villwock, Sophia, Timm, M Cherelle, Buhl, Eva M, Wucherpfennig, Sophie, Cacchi, Claudio, Braunschweig, Till, Knüchel-Clarke, Ruth, Jonigk, Danny, Werlein, Christopher, Bülow, Roman D, Dahl, Edgar, von Stillfried, Saskia, Boor, Peter

“…Multiorgan tropism of SARS-CoV-2 has previously been shown for several major organs. We have comprehensively analyzed 25 different formalin-fixed…”
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SARS‐CoV‐2 RNA screening in routine pathology specimens by Stillfried, Saskia, Villwock, Sophia, Bülow, Roman D., Djudjaj, Sonja, Buhl, Eva M., Maurer, Angela, Ortiz‐Brüchle, Nadina, Celec, Peter, Klinkhammer, Barbara M., Wong, Dickson W.L., Cacchi, Claudio, Braunschweig, Till, Knüchel‐Clarke, Ruth, Dahl, Edgar, Boor, Peter

“…Summary Virus detection methods are important to cope with the SARS‐CoV‐2 pandemics. Apart from the lung, SARS‐CoV‐2 was detected in multiple organs in severe…”
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Tackling stain variability using CycleGAN-based stain augmentation by Bouteldja, Nassim, Hölscher, David L., Bülow, Roman D., Roberts, Ian S.D., Coppo, Rosanna, Boor, Peter

“…Considerable inter- and intra-laboratory stain variability exists in pathology, representing a challenge in development and application of deep learning (DL)…”
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Histopathological biomarkers for predicting the tumour accumulation of nanomedicines by May, Jan-Niklas, Moss, Jennifer I, Mueller, Florian, Golombek, Susanne K, Biancacci, Ilaria, Rizzo, Larissa, Elshafei, Asmaa Said, Gremse, Felix, Pola, Robert, Pechar, Michal, Etrych, Tomáš, Becker, Svea, Trautwein, Christian, Bülow, Roman D, Boor, Peter, Knuechel, Ruth, von Stillfried, Saskia, Storm, Gert, Puri, Sanyogitta, Barry, Simon T, Schulz, Volkmar, Kiessling, Fabian, Ashford, Marianne B, Lammers, Twan

“…The clinical prospects of cancer nanomedicines depend on effective patient stratification. Here we report the identification of predictive biomarkers of the…”
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