Search Results - "Büll, Christian"

Sialoglycans and Siglecs Can Shape the Tumor Immune Microenvironment by van de Wall, Stephanie, Santegoets, Kim C.M., van Houtum, Eline J.H., Büll, Christian, Adema, Gosse J.

“…Sialic acid sugar-carrying glycans, sialoglycans, are aberrantly expressed on many tumor cells and have emerged as potent regulatory molecules involved in…”
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Sialic Acids Sweeten a Tumor's Life by BÜLL, Christian, STOEL, Marieke A, DEN BROK, Martijn H, ADEMA, Gosse J

“…Over four decades ago, specific tumor characteristics were ascribed to the increased expression of sialic acid sugars on the surface of cancer cells, and this…”
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Sialic Acid Mimetics to Target the Sialic Acid–Siglec Axis by Büll, Christian, Heise, Torben, Adema, Gosse J., Boltje, Thomas J.

“…Sialic acid sugars are vital regulators of the immune system through binding to immunosuppressive sialic acid-binding immunoglobulin-like lectin (Siglec)…”
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Potent Metabolic Sialylation Inhibitors Based on C‑5-Modified Fluorinated Sialic Acids by Heise, Torben, Pijnenborg, Johan F. A, Büll, Christian, van Hilten, Niek, Kers-Rebel, Esther D, Balneger, Natasja, Elferink, Hidde, Adema, Gosse J, Boltje, Thomas J

“…Sialic acid sugars on mammalian cells regulate numerous biological processes, while aberrant expression of sialic acid is associated with diseases such as…”
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Sialic acid O-acetylation: From biosynthesis to roles in health and disease by Visser, Eline A., Moons, Sam J., Timmermans, Suzanne B.P.E., de Jong, Heleen, Boltje, Thomas J., Büll, Christian

“…Sialic acids are nine-carbon sugars that frequently cap glycans at the cell surface in cells of vertebrates as well as cells of certain types of invertebrates…”
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An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells by Narimatsu, Yoshiki, Joshi, Hiren J., Nason, Rebecca, Van Coillie, Julie, Karlsson, Richard, Sun, Lingbo, Ye, Zilu, Chen, Yen-Hsi, Schjoldager, Katrine T., Steentoft, Catharina, Furukawa, Sanae, Bensing, Barbara A., Sullam, Paul M., Thompson, Andrew J., Paulson, James C., Büll, Christian, Adema, Gosse J., Mandel, Ulla, Hansen, Lars, Bennett, Eric Paul, Varki, Ajit, Vakhrushev, Sergey Y., Yang, Zhang, Clausen, Henrik

“…The structural diversity of glycans on cells—the glycome—is vast and complex to decipher. Glycan arrays display oligosaccharides and are used to report glycan…”
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Genetic glycoengineering in mammalian cells by Narimatsu, Yoshiki, Büll, Christian, Chen, Yen-Hsi, Wandall, Hans H., Yang, Zhang, Clausen, Henrik

“…Advances in nuclease-based gene-editing technologies have enabled precise, stable, and systematic genetic engineering of glycosylation capacities in mammalian…”
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Probing the binding specificities of human Siglecs by cell-based glycan arrays by Büll, Christian, Nason, Rebecca, Sun, Lingbo, Van Coillie, Julie, Sørensen, Daniel Madriz, Moons, Sam J., Yang, Zhang, Arbitman, Steven, Fernandes, Steve M., Furukawa, Sanae, McBride, Ryan, Nycholat, Corwin M., Adema, Gosse J., Paulson, James C., Schnaar, Ronald L., Boltje, Thomas J., Clausen, Henrik, Narimatsu, Yoshiki

“…Siglecs are a family of sialic acid–binding receptors expressed by cells of the immune system and a few other cell types capable of modulating immune cell…”
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Putting a cap on the glycome: Dissecting human sialyltransferase functions by Mohamed, Khadra A., Kruf, Stijn, Büll, Christian

“…Human glycans are capped with sialic acids and these nine-carbon sugars mediate many of the biological functions and interactions of glycans. Structurally…”
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Targeted Delivery of a Sialic Acid-Blocking Glycomimetic to Cancer Cells Inhibits Metastatic Spread by Büll, Christian, Boltje, Thomas Jan, van Dinther, Eric A. W, Peters, Timo, de Graaf, Annemarie M. A, Leusen, Jeanette H. W, Kreutz, Martin, Figdor, Carl G, den Brok, Martijn H, Adema, Gosse J

“…Sialic acid sugars are overexpressed by cancer cells and contribute to the metastatic cascade at multiple levels. Therapeutic interference of sialic acids,…”
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Display of the human mucinome with defined O-glycans by gene engineered cells by Nason, Rebecca, Büll, Christian, Konstantinidi, Andriana, Sun, Lingbo, Ye, Zilu, Halim, Adnan, Du, Wenjuan, Sørensen, Daniel M., Durbesson, Fabien, Furukawa, Sanae, Mandel, Ulla, Joshi, Hiren J., Dworkin, Leo Alexander, Hansen, Lars, David, Leonor, Iverson, Tina M., Bensing, Barbara A., Sullam, Paul M., Varki, Ajit, Vries, Erik de, de Haan, Cornelis A. M., Vincentelli, Renaud, Henrissat, Bernard, Vakhrushev, Sergey Y., Clausen, Henrik, Narimatsu, Yoshiki

“…Mucins are a large family of heavily O-glycosylated proteins that cover all mucosal surfaces and constitute the major macromolecules in most body fluids…”
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Siglec Signaling in the Tumor Microenvironment by van Houtum, Eline J H, Büll, Christian, Cornelissen, Lenneke A M, Adema, Gosse J

“…Sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of receptors that recognize sialoglycans - sialic acid containing glycans that are…”
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Sweet escape: Sialic acids in tumor immune evasion by Büll, Christian, den Brok, Martijn H., Adema, Gosse J.

“…Sialic acids represent a family of sugar molecules derived from neuraminic acid that frequently terminate glycan chains and contribute to many biological…”
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Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation by den Brok, Martijn H., Büll, Christian, Wassink, Melissa, de Graaf, Annemarie M., Wagenaars, Jori A., Minderman, Marthe, Thakur, Mayank, Amigorena, Sebastian, Rijke, Eric O., Schrier, Carla C., Adema, Gosse J.

“…Saponin-based adjuvants (SBAs) are being used in animal and human (cancer) vaccines, as they induce protective cellular immunity. Their adjuvant potency is a…”
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Sialic Acid Blockade Suppresses Tumor Growth by Enhancing T-cell-Mediated Tumor Immunity by Büll, Christian, Boltje, Thomas J, Balneger, Natasja, Weischer, Sarah M, Wassink, Melissa, van Gemst, Jasper J, Bloemendal, Victor R, Boon, Louis, van der Vlag, Johan, Heise, Torben, den Brok, Martijn H, Adema, Gosse J

“…Sialic acid sugars on the surface of cancer cells have emerged as potent immune modulators that contribute to the immunosuppressive microenvironment and tumor…”
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Human-type sialic acid receptors contribute to avian influenza A virus binding and entry by hetero-multivalent interactions by Liu, Mengying, Huang, Liane Z. X., Smits, Anthony A., Büll, Christian, Narimatsu, Yoshiki, van Kuppeveld, Frank J. M., Clausen, Henrik, de Haan, Cornelis A. M., de Vries, Erik

“…Establishment of zoonotic viruses, causing pandemics like the Spanish flu and Covid-19, requires adaptation to human receptors. Pandemic influenza A viruses…”
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Targeting aberrant sialylation in cancer cells using a fluorinated sialic acid analog impairs adhesion, migration, and in vivo tumor growth by Büll, Christian, Boltje, Thomas J, Wassink, Melissa, de Graaf, Annemarie M A, van Delft, Floris L, den Brok, Martijn H, Adema, Gosse J

“…Cancer cells decorate their surface with a dense layer of sialylated glycans by upregulating the expression of sialyltransferases and other glycogenes…”
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Sialic acid glycoengineering using N-acetylmannosamine and sialic acid analogs by Moons, Sam J, Adema, Gosse J, Derks, Max Tgm, Boltje, Thomas J, Büll, Christian

“…Sialic acids cap the glycans of cell surface glycoproteins and glycolipids. They are involved in a multitude of biological processes and aberrant sialic acid…”
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Identification of global inhibitors of cellular glycosylation by Sørensen, Daniel Madriz, Büll, Christian, Madsen, Thomas D., Lira-Navarrete, Erandi, Clausen, Thomas Mandel, Clark, Alex E., Garretson, Aaron F., Karlsson, Richard, Pijnenborg, Johan F. A., Yin, Xin, Miller, Rebecca L., Chanda, Sumit K., Boltje, Thomas J., Schjoldager, Katrine T., Vakhrushev, Sergey Y., Halim, Adnan, Esko, Jeffrey D., Carlin, Aaron F., Hurtado-Guerrero, Ramon, Weigert, Roberto, Clausen, Henrik, Narimatsu, Yoshiki

“…Small molecule inhibitors of glycosylation enzymes are valuable tools for dissecting glycan functions and potential drug candidates. Screening for inhibitors…”
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Installation of O-glycan sulfation capacities in human HEK293 cells for display of sulfated mucins by Sun, Lingbo, Konstantinidi, Andriana, Ye, Zilu, Nason, Rebecca, Zhang, Yuecheng, Büll, Christian, Kahl-Knutson, Barbro, Hansen, Lars, Leffler, Hakon, Vakhrushev, Sergey Y., Yang, Zhang, Clausen, Henrik, Narimatsu, Yoshiki

“…The human genome contains at least 35 genes that encode Golgi sulfotransferases that function in the secretory pathway, where they are involved in decorating…”
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