Search Results - "Børglum, Anders Dupont"

Analyzing the Role of MicroRNAs in Schizophrenia in the Context of Common Genetic Risk Variants by Hauberg, Mads Engel, Roussos, Panos, Grove, Jakob, Børglum, Anders Dupont, Mattheisen, Manuel

“…The recent implication of 108 genomic loci in schizophrenia marked a great advancement in our understanding of the disease. Against the background of its…”
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Inactivation of the Schizophrenia-associated BRD1 gene in Brain Causes Failure-to-thrive, Seizure Susceptibility and Abnormal Histone H3 Acetylation and N-tail Clipping by Paternoster, Veerle, Edhager, Anders Valdemar, Qvist, Per, Donskov, Julie Grinderslev, Shliaha, Pavel, Jensen, Ole Nørregaard, Mors, Ole, Nielsen, Anders Lade, Børglum, Anders Dupont, Palmfeldt, Johan, Christensen, Jane Hvarregaard

“…Genetic studies have repeatedly shown that the Bromodomain containing 1 gene, BRD1 , is involved in determining mental health, and the importance of the BRD1…”
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Brain proteome changes in female Brd1+/− mice unmask dendritic spine pathology and show enrichment for schizophrenia risk by Paternoster, Veerle, Svanborg, Maria, Edhager, Anders Valdemar, Rajkumar, Anto P., Eickhardt, Esben Ahlburg, Pallesen, Jonatan, Grove, Jakob, Qvist, Per, Fryland, Tue, Wegener, Gregers, Nyengaard, Jens Randel, Mors, Ole, Palmfeldt, Johan, Børglum, Anders Dupont, Christensen, Jane Hvarregaard

“…Genetic and molecular studies have implicated the Bromodomain containing 1 (BRD1) gene in the pathogenesis of schizophrenia and bipolar disorder. Accordingly,…”
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The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation by Paternoster, Veerle, Cömert, Cagla, Kirk, Louise Sand, la Cour, Sanne Hage, Fryland, Tue, Fernandez-Guerra, Paula, Stougaard, Magnus, Nyengaard, Jens Randel, Qvist, Per, Bross, Peter, Børglum, Anders Dupont, Christensen, Jane Hvarregaard

“…Bromodomain containing 1 ( BRD1) encodes an epigenetic regulator that controls the expression of genetic networks linked to mental illness. BRD1 is essential…”
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High-Quality Exome Sequencing of Whole-Genome Amplified Neonatal Dried Blood Spot DNA by Poulsen, Jesper Buchhave, Lescai, Francesco, Grove, Jakob, Bækvad-Hansen, Marie, Christiansen, Michael, Hagen, Christian Munch, Maller, Julian, Stevens, Christine, Li, Shenting, Li, Qibin, Sun, Jihua, Wang, Jun, Nordentoft, Merete, Werge, Thomas Mears, Mortensen, Preben Bo, Børglum, Anders Dupont, Daly, Mark, Hougaard, David Michael, Bybjerg-Grauholm, Jonas, Hollegaard, Mads Vilhelm

“…Stored neonatal dried blood spot (DBS) samples from neonatal screening programmes are a valuable diagnostic and research resource. Combined with information…”
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Quantitative assessment of methyl-esterification and other side reactions in a standard propionylation protocol for detection of histone modifications by Paternoster, Veerle, Edhager, Anders Valdemar, Sibbersen, Christian, Nielsen, Anders Lade, Børglum, Anders Dupont, Christensen, Jane Hvarregaard, Palmfeldt, Johan

“…Histone modifications play an important role in regulating chromatin stability and gene expression, but to date, investigating them remains challenging. In…”
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DNA Methylation at the Neonatal State and at the Time of Diagnosis: Preliminary Support for an Association with the Estrogen Receptor 1, Gamma-Aminobutyric Acid B Receptor 1, and Myelin Oligodendrocyte Glycoprotein in Female Adolescent Patients with OCD by Nissen, Judith Becker, Hansen, Christine Søholm, Starnawska, Anna, Mattheisen, Manuel, Børglum, Anders Dupont, Buttenschøn, Henriette Nørmølle, Hollegaard, Mads

“…Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder. Non-genetic factors and their interaction with genes have attracted increasing attention…”
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Association of Childhood Exposure to Nitrogen Dioxide and Polygenic Risk Score for Schizophrenia With the Risk of Developing Schizophrenia by Horsdal, Henriette Thisted, Agerbo, Esben, McGrath, John Joseph, Vilhjálmsson, Bjarni Jóhann, Antonsen, Sussie, Closter, Ane Marie, Timmermann, Allan, Grove, Jakob, Mok, Pearl L. H., Webb, Roger T., Sabel, Clive Eric, Hertel, Ole, Sigsgaard, Torben, Erikstrup, Christian, Hougaard, David Michael, Werge, Thomas, Nordentoft, Merete, Børglum, Anders Dupont, Mors, Ole, Mortensen, Preben Bo, Brandt, Jørgen, Geels, Camilla, Pedersen, Carsten Bøcker

“…Importance Schizophrenia is a highly heritable psychiatric disorder, and recent studies have suggested that exposure to nitrogen dioxide (NO2) during childhood…”
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Co-occurring hydrocephalus in autism spectrum disorder: a Danish population-based cohort study by Munch, Tina Nørgaard, Hedley, Paula Louise, Hagen, Christian Munch, Bækvad-Hansen, Marie, Bybjerg-Grauholm, Jonas, Grove, Jakob, Nordentoft, Merete, Børglum, Anders Dupont, Mortensen, Preben Bo, Werge, Thomas Mears, Melbye, Mads, Hougaard, David Michael, Christiansen, Michael

“…The association between autism spectrum disorder and hydrocephalus is not well understood, despite demonstrated links between autism spectrum disorder and…”
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The Genome-Wide DNA Methylation Profile of Peripheral Blood Is Not Systematically Changed by Short-Time Storage at Room Temperature by Staunstrup, Nicklas Heine, Starnawska, Anna, Nyegaard, Mette, Nielsen, Anders Lade, Børglum, Anders Dupont, Mors, Ole

“…Background: Epigenetic epidemiology has proven an important research discipline in the delineation of diseases of complex etiology. The approach, in such…”
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Association Between Childhood Green Space, Genetic Liability, and the Incidence of Schizophrenia by Engemann, Kristine, Pedersen, Carsten Bøcker, Agerbo, Esben, Arge, Lars, Børglum, Anders Dupont, Erikstrup, Christian, Hertel, Ole, Hougaard, David Michael, McGrath, John J, Mors, Ole, Mortensen, Preben Bo, Nordentoft, Merete, Sabel, Clive Eric, Sigsgaard, Torben, Tsirogiannis, Constantinos, Vilhjálmsson, Bjarni Jóhann, Werge, Thomas, Svenning, Jens-Christian, Horsdal, Henriette Thisted

“…Abstract Childhood exposure to green space has previously been associated with lower risk of developing schizophrenia later in life. It is unclear whether this…”
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The importance of data structure in statistical analysis of dendritic spine morphology by Paternoster, Veerle, Rajkumar, Anto P., Nyengaard, Jens Randel, Børglum, Anders Dupont, Grove, Jakob, Christensen, Jane Hvarregaard

“…•Data collection for dendritic spine morphology often results in multilevel data structure.•The need for implementation of data structure in statistical models…”
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The Schizophrenia-Associated BRD1 Gene Regulates Behavior, Neurotransmission, and Expression of Schizophrenia Risk Enriched Gene Sets in Mice by Qvist, Per, Christensen, Jane Hvarregaard, Vardya, Irina, Rajkumar, Anto Praveen, Mørk, Arne, Paternoster, Veerle, Füchtbauer, Ernst-Martin, Pallesen, Jonatan, Fryland, Tue, Dyrvig, Mads, Hauberg, Mads Engel, Lundsberg, Birgitte, Fejgin, Kim, Nyegaard, Mette, Jensen, Kimmo, Nyengaard, Jens Randel, Mors, Ole, Didriksen, Michael, Børglum, Anders Dupont

“…Abstract Background The schizophrenia-associated BRD1 gene encodes a transcriptional regulator whose comprehensive chromatin interactome is enriched with…”
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A genome-wide search for linkage to allergic rhinitis in Danish sib-pair families by KRUSE, Lisbeth Venø, NYEGAARD, Mette, BØRGLUM, Anders Dupont, CHRISTENSEN, Ulla, MØLLER-LARSEN, Steffen, HAAGERUP, Annette, DELEURAN, Mette, HANSEN, Lars Gudmund, VENØ, Stine Krogh, GOOSSENS, Dirk, DEL-FAVERO, Jurgen

“…Allergic rhinitis (AR) is a complex disorder with a polygenic, multifactorial aetiology. Twin studies have found the genetic contribution to be substantial. We…”
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A functional CD86 polymorphism associated with asthma and related allergic disorders by Corydon, Thomas Juhl, Haagerup, Annette, Jensen, Thomas Gryesten, Binderup, Helle Glud, Petersen, Mikkel Steen, Kaltoft, Keld, Vestbo, Jørgen, Kruse, Torben Arvid, Børglum, Anders Dupont

“…Background: Several studies have documented a substantial genetic component in the aetiology of allergic diseases and a number of atopy susceptibility loci…”
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Differential activity of transcribed enhancers in the prefrontal cortex of 537 cases with schizophrenia and controls by Hauberg, Mads E., Fullard, John F., Zhu, Lingxue, Cohain, Ariella T., Giambartolomei, Claudia, Misir, Ruth, Reach, Sarah, Johnson, Jessica S., Wang, Minghui, Mattheisen, Manuel, Børglum, Anders Dupont, Zhang, Bin, Sieberts, Solveig K., Peters, Mette A., Domenici, Enrico, Schadt, Eric E., Devlin, Bernie, Sklar, Pamela, Roeder, Kathryn, Roussos, Panos

“…Transcription at enhancers is a widespread phenomenon which produces so-called enhancer RNA (eRNA) and occurs in an activity-dependent manner. However, the…”
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Schizophrenia risk variants affecting microRNA function and site-specific regulation of NT5C2 by miR-206 by Hauberg, Mads Engel, Holm-Nielsen, Marie Hebsgaard, Mattheisen, Manuel, Askou, Anne Louise, Grove, Jakob, Børglum, Anders Dupont, Corydon, Thomas Juhl

“…Abstract Despite the identification of numerous schizophrenia-associated genetic variants, few have been examined functionally to identify and characterize the…”
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Genomics of mental disorders by Mors, Ole, Børglum, Anders Dupont

“…The heritability of mental disorders is high, but it has been very difficult to unravel the genetic architecture. In the past five years, unprecedented…”
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Myosin light chain mutations in familial hypertrophic cardiomyopathy: phenotypic presentation and frequency in Danish and South African populations by Andersen, Paal Skytt, Havndrup, Ole, Bundgaard, Henning, Moolman-Smook, Johanna Catharina, Larsen, Lars Allan, Mogensen, Jens, Brink, Paul Andries, Børglum, Anders Dupont, Corfield, Valerie Ann, Kjeldsen, Keld, Vuust, Jens, Christiansen, Michael

“…Mutations in α-tropomyosin (TPM1), 5 troponin T (TNNT2), 5 6 troponin I (TNNI3), 6 cardiac α-actin (ACTC), 7 titin (TTN), 8 and the essential (MYL3) and the…”
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Development and application of linkage analysis in genetic diagnosis of familial hypertrophic cardiomyopathy by MOGENSEN, JENS, ANDERSEN, PAAL SKYTT, STEFFENSEN, ULLA, CHRISTIANSEN, MICHAEL, EGEBLAD, HENRIK, GREGERSEN, NIELS, BØRGLUM, ANDERS DUPONT

“…[...]the pathogenic impact of any amino acid variation identified needs to be based on substantial evidence since a genetic diagnosis may have profound…”
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