Search Results - "Bögel, Gábor"
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The role of PI3K-Akt-mTOR axis in Warburg effect and its modification by specific protein kinase inhibitors in human and rat inflammatory macrophages
Published in International immunopharmacology (15-11-2024)“…•Expression of HIF-1α, NOS2 and inflammatory cytokines increased in inflammatory macrophages.•Increased expressions of HIF-1α, NOS2 and IP-10 were reduced by…”
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2
Production of NOS2 and inflammatory cytokines is reduced by selected protein kinase inhibitors with partial repolarization of HL-60 derived and human blood macrophages
Published in Heliyon (01-01-2022)“…JAK/STAT pathway plays a well-known role in macrophage polarization, but other signaling routes may also be involved. The aim of this study was to identify new…”
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The homolog of the five SH3-domain protein (HOFI/SH3PXD2B) regulates lamellipodia formation and cell spreading
Published in PloS one (23-08-2011)“…Motility of normal and transformed cells within and across tissues requires specialized subcellular structures, e.g. membrane ruffles, lamellipodia and…”
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Complex formation of EphB1/Nck/Caskin1 leads to tyrosine phosphorylation and structural changes of the Caskin1 SH3 domain
Published in Cell communication and signaling (27-11-2012)“…Scaffold proteins have an important role in the regulation of signal propagation. These proteins do not possess any enzymatic activity but can contribute to…”
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Decreasing effects of protein kinase inhibitors on the expression of NOS2 and inflammatory cytokines and on phagocytosis in rat peritoneal macrophages is partly related to repolarization
Published in Molecular immunology (01-01-2023)“…The JAK/STAT (Janus Kinase/Signal Transducer and Activator of Transcription) pathway plays a pivotal role in macrophage polarization, but other signaling…”
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Accumulation of the PX domain mutant Frank-ter Haar syndrome protein Tks4 in aggresomes
Published in Cell communication and signaling (17-07-2015)“…Cells deploy quality control mechanisms to remove damaged or misfolded proteins. Recently, we have reported that a mutation (R43W) in the Frank-ter Haar…”
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EGF regulates tyrosine phosphorylation and membrane-translocation of the scaffold protein Tks5
Published in Journal of molecular signaling (07-08-2013)“…Tks5/FISH is a scaffold protein comprising of five SH3 domains and one PX domain. Tks5 is a substrate of the tyrosine kinase Src and is required for the…”
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Frank-ter Haar Syndrome Protein Tks4 Regulates Epidermal Growth Factor-dependent Cell Migration
Published in The Journal of biological chemistry (07-09-2012)“…Mutations in the SH3PXD2B gene coding for the Tks4 protein are responsible for the autosomal recessive Frank-ter Haar syndrome. Tks4, a substrate of Src…”
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Inducible phosphorylation of cortactin is not necessary for cortactin-mediated actin polymerisation
Published in Cellular signalling (01-06-2006)“…Cortactin is an SH3 domain-containing protein that contributes to the formation of dynamic cortical actin-associated structures, such as lamellipodia and…”
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Cortactin is required for integrin-mediated cell spreading
Published in Immunology Letters (15-04-2006)“…Cortactin is an SH3 domain-containing protein that contributes to the formation of dynamic cortical actin-associated structures, such as lamellipodia and…”
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11
The Homolog of the Five SH3-Domain Protein
Published in PloS one (23-08-2011)“…Motility of normal and transformed cells within and across tissues requires specialized subcellular structures, e.g. membrane ruffles, lamellipodia and…”
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The Novel Adapter HOFI, a Homolog of FISH/Tks5 Regulates Lamellipodia Formation and Cell Spreading
Published in Clinical immunology (Orlando, Fla.) (2010)Get full text
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