Monocyte-lymphocyte, neutrophil-lymphocyte, and platelet-lymphocyte ratios as inflammatory biomarkers of clinical dengue severity

The literature describes monocyte-lymphocyte (MLR), neutrophil-lymphocyte (NLR), and platelet-lymphocyte (PLR) ratios as prognostic biomarkers. However, in the case of dengue infection, patient clinical management and nonspecific laboratory tests determine the prognosis. Therefore, this study analyz...

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Bibliographic Details
Published in:	Bioscience journal Vol. 40; p. e40038
Main Authors:	Böer, Luiza Monteiro, Junqueira, Isabela Cinquini, Nascimento, Thais Cardoso do, Guilarde, Adriana Oliveira, Féres, Valéria Christina de Rezende, Alcântara, Keila Correia de
Format:	Journal Article
Language:	English
Published:	Universidade Federal de Uberlândia 17-07-2024
Subjects:	blood cell count dengue hemorrhagic fever dengue virus leukocyte count prognostic
Online Access:	Get full text
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Summary:	The literature describes monocyte-lymphocyte (MLR), neutrophil-lymphocyte (NLR), and platelet-lymphocyte (PLR) ratios as prognostic biomarkers. However, in the case of dengue infection, patient clinical management and nonspecific laboratory tests determine the prognosis. Therefore, this study analyzed MLR, NLR, and PLR as prognostic biomarkers of dengue infection. Our study was based on a clinical cohort of dengue patients in Brazil between 2012 and 2013. From 193 patients, 164 (85.0%) were classified as dengue fever (DF), 19 (9.8%) as dengue hemorrhagic fever (DHF), and 10 (5.2%) as intermediate DF/DHF. DHF cases were significantly associated with MLR > 0.13 (OR: 5.72, 95% CI: 1.28-25.60, p < 0.05) and PLR ≤ 80.68 (OR: 4.26; 95% CI 1.60-11.33; p < 0.05). Our results suggest that MLR increase, and PLR decrease indicate a higher likelihood of worsening the clinical status.
ISSN:	1981-3163 1981-3163
DOI:	10.14393/BJ-v40n0a2024-67413