Search Results - "Bézard, E."

Neurochemical plasticity in the enteric nervous system of a primate animal model of experimental Parkinsonism by Chaumette, T., Lebouvier, T., Aubert, P., Lardeux, B., Qin, C., Li, Q., Accary, D., Bézard, E., Bruley Des Varannes, S., Derkinderen, P., Neunlist, M.

“…Emerging evidences suggest that the enteric nervous system (ENS) is affected by the degenerative process in Parkinson’s disease (PD). In addition lesions in…”
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Contribution of pre-synaptic mechanisms to l -DOPA-induced dyskinesia by Carta, M, Bezard, E

“…Abstract Positron emission tomography (PET) imaging studies have shown that peak-dose dyskinesia is associated to abnormally high levels of synaptic dopamine…”
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Effect of serotonin transporter blockade on L-DOPA-induced dyskinesia in animal models of Parkinson’s disease by Fidalgo, C, Ko, W.K.D, Tronci, E, Li, Q, Stancampiano, R, Chuan, Q, Bezard, E, Carta, M

“…Highlights • The serotonergic system plays a key role in LID. • The SSRI citalopram is able to fully counteract LID in 6-OHDA-lesioned rats. • Citalopram also…”
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Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of l-DOPA-induced dyskinesia by Muñoz, Ana, Li, Qin, Gardoni, Fabrizio, Marcello, Elena, Qin, Chuan, Carlsson, Thomas, Kirik, Deniz, Di Luca, Monica, Björklund, Anders, Bezard, Erwan, Carta, Manolo

“…Appearance of dyskinesia is a common problem of long-term l-DOPA treatment in Parkinson's disease patients and represents a major limitation for the…”
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The dopamine D3 receptor: a therapeutic target for the treatment of neuropsychiatric disorders by Sokoloff, P, Diaz, J, Le Foll, B, Guillin, O, Leriche, L, Bezard, E, Gross, C

“…The role of the D(3) receptor has remained largely elusive before the development of selective research tools, such as selective radioligands, antibodies,…”
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Animal models of Parkinson's disease by Bezard, E

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Blood withdrawal affects iron store dynamics in primates with consequences on monoaminergic system function by Hyacinthe, C, De Deurwaerdere, P, Thiollier, T, Li, Q, Bezard, E, Ghorayeb, I

“…Highlights • Iron-related parameters of naive macaques show circadian variations in serum and CSF. • Blood withdrawals decrease serum iron levels but increase…”
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In utero delivery of rAAV2/9 induces neuronal expression of the transgene in the brain: towards new models of Parkinson’s disease by Chansel-Debordeaux, L, Bourdenx, M, Dovero, S, Grouthier, V, Dutheil, N, Espana, A, Groc, L, Jimenez, C, Bezard, E, Dehay, B

“…Animal models are essential tools for basic pathophysiological research as well as validation of therapeutic strategies for curing human diseases. However,…”
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Differential behavioral effects of partial bilateral lesions of ventral tegmental area or substantia nigra pars compacta in rats by Pioli, E.Y, Meissner, W, Sohr, R, Gross, C.E, Bezard, E, Bioulac, B.H

“…Abstract Akinesia (or absence of movement) is a prominent feature of Parkinson's disease. Akinetic symptoms, however, are also observed in depression and…”
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O.063 Involvement of canonical and non-canonical D1 signaling pathways in L-dopa-induced dyskinesia by Bezard, E

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D1 dopamine receptor-mediated LTP at GABA synapses encodes motivation to self-administer cocaine in rats by Krawczyk, Michal, Mason, Xenos, DeBacker, Julian, Sharma, Robyn, Normandeau, Catherine P, Hawken, Emily R, Di Prospero, Cynthia, Chiang, Cindy, Martinez, Audrey, Jones, Andrea A, Doudnikoff, Évelyne, Caille, Stephanie, Bézard, Erwan, Georges, François, Dumont, Éric C

“…Enhanced motivation to take drugs is a central characteristic of addiction, yet the neural underpinning of this maladaptive behavior is still largely unknown…”
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A Novel mglur4 compound alleviates motor symptoms in primate models of parkinson's disease by Charvin, D., Di Paolo, T., Bezard, E., Halldin, C., Duvey, G., Gregoire, L., Takano, A., Pioli, E., Medori, R., Conquet, F.

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Alterations of striatal NMDA receptor subunits associated with the development of dyskinesia in the MPTP-lesioned primate model of Parkinson's disease by Hallett, P.J., Dunah, A.W., Ravenscroft, P., Zhou, S., Bezard, E., Crossman, A.R., Brotchie, J.M., Standaert, D.G.

“…The development of dyskinesias and other motor complications greatly limits the use of levodopa therapy in Parkinson's disease (PD). Studies in rodent models…”
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l-DOPA reverses the MPTP-induced elevation of the arrestin2 and GRK6 expression and enhanced ERK activation in monkey brain by Bezard, E., Gross, C.E., Qin, Li, Gurevich, V.V., Benovic, J.L., Gurevich, E.V.

“…Dysregulation of dopamine receptors (DARs) is believed to contribute to Parkinson disease (PD) pathology. G protein-coupled receptors (GPCR) undergo…”
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Neuroscience disease models by Bezard, E, Pisani, A, Berton, O

“…This article is part of a Special Issue entitled: Neuroscience Disease Models…”
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Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey by Boraud, Th, Bezard, E, Guehl, D, Bioulac, B, Gross, Ch

“…We studied the effects of l-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a…”
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Pathophysiology and therapy of L-Dopa-induced dyskinesia by Hadj Tahar, A, Bézard, E, Grondin, R, Gross, C E, Bédard, P J

“…Involuntary movements, or dyskinesias, represent a debilitating complication of levodopa therapy for Parkinson's disease. Dyskinesia is, ultimately,…”
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Ratio of Inhibited-to-Activated Pallidal Neurons Decreases Dramatically During Passive Limb Movement in the MPTP-Treated Monkey by Boraud, T, Bezard, E, Bioulac, B, Gross, C. E

“…Basal Gang, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5543, Université Victor Segalen Bordeaux 2, 33076 Bordeaux Cedex, France…”
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2.231 ADX48621, A MGLUR5 NEGATIVE ALLOSTERIC MODULATOR ALLEVIATES L-DOPA-INDUCED CHOREA AND DYSTONIA IN THE MPTP MACAQUE MODEL OF PARKINSON'S DISEASE by Keywood, C, Bezard, E, Hill, M, Li, Q, Girard, F, Poli, S, Mutel, V

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Unraveling substantia nigra sequential gene expression in a progressive MPTP-lesioned macaque model of Parkinson's disease by Bassilana, F., Mace, N., Li, Q., Stutzmann, J.M., Gross, C.E., Pradier, L., Benavides, J., Ménager, J., Bezard, E.

“…Taking advantage of a progressive nonhuman primate model mimicking Parkinson's disease (PD) evolution, we monitored transcriptional fluctuations in the…”
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