Search Results - "Bétourné, Alexandre"

β2 -Adrenoceptor agonists as novel, safe and potentially effective therapies for Amyotrophic lateral sclerosis (ALS) by Bartus, Raymond T, Bétourné, Alexandre, Basile, Anthony, Peterson, Bethany L, Glass, Jonathan, Boulis, Nicholas M

“…Abstract Amyotrophic lateral sclerosis (ALS) is a chronic and progressive neuromuscular disease for which no cure exists and better treatment options are…”
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Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling by Bertholet, Ambre M., Kazak, Lawrence, Chouchani, Edward T., Bogaczyńska, Marta G., Paranjpe, Ishan, Wainwright, Gabrielle L., Bétourné, Alexandre, Kajimura, Shingo, Spiegelman, Bruce M., Kirichok, Yuriy

“…Cold and other environmental factors induce “browning” of white fat depots—development of beige adipocytes with morphological and functional resemblance to…”
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HSPA9/Mortalin mediates axo-protection and modulates mitochondrial dynamics in neurons by Ferré, Cécile A., Thouard, Anne, Bétourné, Alexandre, Le Dorze, Anne-Louise, Belenguer, Pascale, Miquel, Marie-Christine, Peyrin, Jean-Michel, Gonzalez-Dunia, Daniel, Szelechowski, Marion

“…Mortalin is a mitochondrial chaperone protein involved in quality control of proteins imported into the mitochondrial matrix, which was recently described as a…”
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Protein kinase C inhibition rescues manic-like behaviors and hippocampal cell proliferation deficits in the sleep deprivation model of mania by Abrial, Erika, Bétourné, Alexandre, Etiévant, Adeline, Lucas, Guillaume, Scarna, Hélène, Lambás-Señas, Laura, Haddjeri, Nasser

“…Recent studies revealed that bipolar disorder may be associated with deficits of neuroplasticity. Additionally, accumulating evidence has implicated…”
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Spinal cord and brain concentrations of riluzole after oral and intrathecal administration: A potential new treatment route for amyotrophic lateral sclerosis by Keifer, Orion P, Gutierrez, Juanmarco, Butt, Mark T, Cramer, Sarah D, Bartus, Raymond, Tansey, Malu, Deaver, Daniel, Betourne, Alexandre, Boulis, Nicholas M

“…Riluzole is the only treatment known to improve survival in patients with Amyotrophic Lateral Sclerosis (ALS). However, oral riluzole efficacy is modest at…”
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Focal and dose-dependent neuroprotection in ALS mice following AAV2-neurturin delivery by Gross, Sarah K., Shim, Bo Sung, Bartus, Raymond T., Deaver, Dan, McEachin, Zachary, Bétourné, Alexandre, Boulis, Nicholas M., Maragakis, Nicholas J.

“…Neurotrophic factors as candidates for ALS therapeutics have previously been studied in the context of attempts to slow disease progression. For a variety of…”
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Borna disease virus phosphoprotein modulates epigenetic signaling in neurons to control viral replication by Bonnaud, Emilie M, Szelechowski, Marion, Bétourné, Alexandre, Foret, Charlotte, Thouard, Anne, Gonzalez-Dunia, Daniel, Malnou, Cécile E

“…Understanding the modalities of interaction of neurotropic viruses with their target cells represents a major challenge that may improve our knowledge of many…”
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A viral peptide that targets mitochondria protects against neuronal degeneration in models of Parkinson’s disease by Szelechowski, Marion, Bétourné, Alexandre, Monnet, Yann, Ferré, Cécile A., Thouard, Anne, Foret, Charlotte, Peyrin, Jean-Michel, Hunot, Stéphane, Gonzalez-Dunia, Daniel

“…Mitochondrial dysfunction is a common feature of many neurodegenerative disorders, notably Parkinson’s disease. Consequently, agents that protect mitochondria…”
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The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease by Bakkar, Nadine, Starr, Alexander, Rabichow, Benjamin E., Lorenzini, Ileana, McEachin, Zachary T., Kraft, Robert, Chaung, Matthew, Macklin-Isquierdo, Sam, Wingfield, Taylor, Carhart, Briggs, Zahler, Nathan, Chang, Wen-Hsuan, Bassell, Gary J., Betourne, Alexandre, Boulis, Nicholas, Alworth, Samuel V., Ichida, Justin K., August, Paul R., Zarnescu, Daniela C., Sattler, Rita, Bowser, Robert

“…Disruption in copper homeostasis causes a number of cognitive and motor deficits. Wilson's disease and Menkes disease are neurodevelopmental disorders…”
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Hippocampal expression of a virus-derived protein impairs memory in mice by Bétourné, Alexandre, Szelechowski, Marion, Thouard, Anne, Abrial, Erika, Jean, Arnaud, Zaidi, Falek, Foret, Charlotte, Bonnaud, Emilie M., Charlier, Caroline M., Suberbielle, Elsa, Malnou, Cécile E., Granon, Sylvie, Rampon, Claire, Gonzalez-Dunia, Daniel

“…The analysis of the biology of neurotropic viruses, notably of their interference with cellular signaling, provides a useful tool to get further insight into…”
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Transient activation of the CA3 Kappa opioid system in the dorsal hippocampus modulates complex memory processing in mice by Daumas, Stéphanie, Betourne, Alexandre, Halley, Hélène, Wolfer, David P., Lipp, Hans-Peter, Lassalle, Jean-Michel, Francés, Bernard

“…The hippocampus plays a central role in various forms of complex learning and memory. Opioid peptides and receptors are abundant in the hippocampus. These…”
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Involvement of hippocampal CA3 KATP channels in contextual memory by Betourne, Alexandre, Bertholet, Ambre M., Labroue, Elodie, Halley, Hélène, Sun, Hong Shuo, Lorsignol, Anne, Feng, Zhong-Ping, French, Robert J., Penicaud, Luc, Lassalle, Jean-Michel, Frances, Bernard

“…This paper evaluates the involvement of hippocampal ATP-sensitive potassium channels (KATP) in learning and memory. After confirming expression of the Kir6.2…”
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β 2 -Adrenoceptor agonists as novel, safe and potentially effective therapies for Amyotrophic lateral sclerosis (ALS) by Bartus, Raymond T., Bétourné, Alexandre, Basile, Anthony, Peterson, Bethany L., Glass, Jonathan, Boulis, Nicholas M.

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The future of rare disease drug development: the rare disease cures accelerator data analytics platform (RDCA-DAP) by Barrett, Jeffrey S., Betourne, Alexandre, Walls, Ramona L., Lasater, Kara, Russell, Scott, Borens, Amanda, Rohatagi, Shlok, Roddy, Will

“…Rare disease drug development is wrought with challenges not the least of which is access to the limited data currently available throughout the rare disease…”
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321 Development of Intrathecal Riluzole: A New Route of Administration for the Treatment of Amyotrophic Lateral Sclerosis Patients by Gutierrez, Juanmarco, Federici, Thais, Peterson, Bethany, Bartus, Ray, Betourne, Alexandre, Boulis, Nicholas M.

“…Abstract INTRODUCTION: Oral administration of riluzole is the only Food and Drug Administration-approved therapy for amyotrophic lateral sclerosis (ALS)…”
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Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling by Bertholet, Ambre M., Kazak, Lawrence, Chouchani, Edward T., Bogaczynska, Marta G., Paranjpe, Ishan, Wainwright, Gabrielle L., Betourne, Alexandre, Kajimura, Shingo, Spiegelman, Bruce M., Kirichok, Yuriy

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Involvement of hippocampal CA3 K ATP channels in contextual memory by Betourne, Alexandre, Bertholet, Ambre M., Labroue, Elodie, Halley, Hélène, Sun, Hong Shuo, Lorsignol, Anne, Feng, Zhong-Ping, French, Robert J., Penicaud, Luc, Lassalle, Jean-Michel, Frances, Bernard

“…This paper evaluates the involvement of hippocampal ATP-sensitive potassium channels (K ATP) in learning and memory. After confirming expression of the Kir6.2…”
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Central locomotor and cognitive effects of a NPFF receptor agonist in mouse by Betourne, Alexandre, Marty, Virginie, Ceccom, Johnatan, Halley, Hélène, Lassalle, Jean-Michel, Zajac, Jean-Marie, Frances, Bernard, Mouledous, Lionel

“…NPFF receptors are expressed in several brain regions directly or indirectly involved in cognition and behavior. However, the cognitive effects of the NPFF…”
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A neuropeptide FF agonist blocks the acquisition of conditioned place preference to morphine in C57Bl/6J mice by Marchand, Stéphane, Betourne, Alexandre, Marty, Virginie, Daumas, Stéphanie, Halley, Hélène, Lassalle, Jean-Michel, Zajac, Jean-Marie, Frances, Bernard

“…Neuropeptide FF behaves as an opioid-modulating peptide that seems to be involved in morphine tolerance and physical dependence. Nevertheless, the effects of…”
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Decreased motivational properties of morphine in mouse models of cancerous- or inflammatory-chronic pain: implication of supraspinal NPFF2 receptors by Betourne, Alexandre, Familiades, Julien, Lacassagne, Ludovic, Halley, Helene, Cazales, Martine, Ducommun, Bernard, Lassalle, Jean-Michel, Zajac, Jean-Marie, Frances, Bernard

“…Our main purpose was to evaluate the influence of cancer pain on the rewarding properties of morphine. Opioids are very addictive when used by healthy persons,…”
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