Search Results - "Bértolo, Cristina"

A Combined PD-1/C5a Blockade Synergistically Protects against Lung Cancer Growth and Metastasis by Ajona, Daniel, Ortiz-Espinosa, Sergio, Moreno, Haritz, Lozano, Teresa, Pajares, María J, Agorreta, Jackeline, Bértolo, Cristina, Lasarte, Juan J, Vicent, Silvestre, Hoehlig, Kai, Vater, Axel, Lecanda, Fernando, Montuenga, Luis M, Pio, Ruben

“…Disruption of the programmed cell death protein 1 (PD-1) pathway with immune checkpoint inhibitors represents a major breakthrough in the treatment of…”
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YES1 Drives Lung Cancer Growth and Progression and Predicts Sensitivity to Dasatinib by Garmendia, Irati, Pajares, María J, Hermida-Prado, Francisco, Ajona, Daniel, Bértolo, Cristina, Sainz, Cristina, Lavín, Amaya, Remírez, Ana B, Valencia, Karmele, Moreno, Haritz, Ferrer, Irene, Behrens, Carmen, Cuadrado, Myriam, Paz-Ares, Luis, Bustelo, Xosé R, Gil-Bazo, Ignacio, Alameda, Daniel, Lecanda, Fernando, Calvo, Alfonso, Felip, Enriqueta, Sánchez-Céspedes, Montse, Wistuba, Ignacio I, Granda-Diaz, Rocio, Rodrigo, Juan Pablo, García-Pedrero, Juana María, Pio, Ruben, Montuenga, Luis M, Agorreta, Jackeline

“…The characterization of new genetic alterations is essential to assign effective personalized therapies in non-small cell lung cancer (NSCLC). Furthermore,…”
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DSTYK inhibition increases the sensitivity of lung cancer cells to T cell-mediated cytotoxicity by Valencia, Karmele, Echepare, Mirari, Teijeira, Álvaro, Pasquier, Andrea, Bértolo, Cristina, Sainz, Cristina, Tamayo, Ibon, Picabea, Beñat, Bosco, Graziella, Thomas, Roman, Agorreta, Jackeline, López-Picazo, José María, Frigola, Joan, Amat, Ramon, Calvo, Alfonso, Felip, Enriqueta, Melero, Ignacio, Montuenga, Luis M

“…Lung cancer remains the leading cause of cancer-related death worldwide. We identify DSTYK, a dual serine/threonine and tyrosine non-receptor protein kinase,…”
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The oncogenic RNA-binding protein SRSF1 regulates LIG1 in non-small cell lung cancer by Martínez-Terroba, Elena, Ezponda, Teresa, Bértolo, Cristina, Sainz, Cristina, Remírez, Ana, Agorreta, Jackeline, Garmendia, Irati, Behrens, Carmen, Pio, Ruben, Wistuba, Ignacio I., Montuenga, Luis M., Pajares, María J.

“…In recent years, the relevance of RNA metabolism has been increasingly recognized in a variety of diseases. Modifications in the levels of RNA-binding proteins…”
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X-box Binding Protein 1 Regulates Unfolded Protein, Acute-Phase, and DNA Damage Responses During Regeneration of Mouse Liver by Argemí, Josepmaria, Kress, Theresia R, Chang, Haisul C.Y, Ferrero, Roberto, Bértolo, Cristina, Moreno, Haritz, González-Aparicio, Manuela, Uriarte, Iker, Guembe, Laura, Segura, Víctor, Hernández-Alcoceba, Rubén, Ávila, Matías A, Amati, Bruno, Prieto, Jesús, Aragón, Tomás

“…Background & Aims Liver regeneration after partial hepatectomy (PH) increases the protein folding burden at the endoplasmic reticulum of remnant hepatocytes,…”
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Two cell line models to study multiorganic metastasis and immunotherapy in lung squamous cell carcinoma by Valencia, Karmele, Sainz, Cristina, Bértolo, Cristina, de Biurrun, Gabriel, Agorreta, Jackeline, Azpilikueta, Arantza, Larrayoz, Marta, Bosco, Graziella, Zandueta, Carolina, Redrado, Miriam, Redín, Esther, Exposito, Francisco, Serrano, Diego, Echepare, Mirari, Ajona, Daniel, Melero, Ignacio, Pio, Ruben, Thomas, Roman, Calvo, Alfonso, Montuenga, Luis M

“…There is a paucity of adequate mouse models and cell lines available to study lung squamous cell carcinoma (LUSC). We have generated and characterized two…”
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Short-term starvation reduces IGF-1 levels to sensitize lung tumors to PD-1 immune checkpoint blockade by Ajona, Daniel, Ortiz-Espinosa, Sergio, Lozano, Teresa, Exposito, Francisco, Calvo, Alfonso, Valencia, Karmele, Redrado, Miriam, Remírez, Ana, Lecanda, Fernando, Alignani, Diego, Lasarte, Juan J, Macaya, Irati, Senent, Yaiza, Bértolo, Cristina, Sainz, Cristina, Gil-Bazo, Ignacio, Eguren-Santamaría, Iñaki, Lopez-Picazo, Jose M, Gonzalez, Alvaro, Perez-Gracia, Jose L, de Andrea, Carlos E, Vicent, Silvestre, Sanmamed, Miguel F, Montuenga, Luis M, Pio, Ruben

“…Harnessing the immune system by blocking the programmed cell death protein 1 (PD-1) pathway has been a major breakthrough in non-small-cell lung cancer…”
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CD8 down-regulation on cytotoxic T lymphocytes of patients with endometrioid endometrial carcinomas by Pascual-García, Mónica, PhD, Bértolo, Cristina, PhD, Nieto, Juan C., PhD, Serrat, Neus, MD, PhD, Espinosa, Íñigo, MD, PhD, D'Angelo, Emanuela, MD, PhD, Muñoz, Raquel, MD, Rovira, Ramón, MD, Vidal, Silvia, PhD, Prat, Jaime, MD, PhD, FRC Path

“…Carcinogenesis is a multistep process in which cancer cells and tumor stroma cells play important roles. T lymphocytes are immune constituents of tumor stroma…”
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SRC family kinase (SFK) inhibitor dasatinib improves the antitumor activity of anti-PD-1 in NSCLC models by inhibiting Treg cell conversion and proliferation by Redin, Esther, Garmendia, Irati, Lozano, Teresa, Serrano, Diego, Senent, Yaiza, Redrado, Miriam, Villalba, Maria, De Andrea, Carlos E, Exposito, Francisco, Ajona, Daniel, Ortiz-Espinosa, Sergio, Remirez, Ana, Bertolo, Cristina, Sainz, Cristina, Garcia-Pedrero, Juana, Pio, Ruben, Lasarte, Juan, Agorreta, Jackeline, Montuenga, Luis M, Calvo, Alfonso

“…IntroductionThe use of immune-checkpoint inhibitors has drastically improved the management of patients with non-small cell lung cancer (NSCLC), but innate and…”
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Stromal signatures in endometrioid endometrial carcinomas by Espinosa, Iñigo, Catasus, Lluis, D′Angelo, Emanuela, Mozos, Ana, Pedrola, Nuria, Bértolo, Cristina, Ferrer, Irene, Zannoni, Gian Franco, West, Robert B, van de Rijn, Matt, Matias-Guiu, Xavier, Prat, Jaime

“…The pattern of myometrial invasion in endometrioid endometrial carcinomas varies considerably; ie, from widely scattered glands and cell nests, often…”
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DrugSniper, a Tool to Exploit Loss-Of-Function Screens, Identifies CREBBP as a Predictive Biomarker of VOLASERTIB in Small Cell Lung Carcinoma (SCLC) by Carazo, Fernando, Bértolo, Cristina, Castilla, Carlos, Cendoya, Xabier, Campuzano, Lucía, Serrano, Diego, Gimeno, Marian, Planes, Francisco J, Pio, Ruben, Montuenga, Luis M, Rubio, Angel

“…The development of predictive biomarkers of response to targeted therapies is an unmet clinical need for many antitumoral agents. Recent genome-wide…”
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Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice by Vicente-Dueñas, Carolina, Fontán, Lorena, Gonzalez-Herrero, Ines, Romero-Camarero, Isabel, Segura, Victor, Aznar, M. Angela, Alonso-Escudero, Esther, Campos-Sanchez, Elena, Ruiz-Roca, Lucía, Barajas-Diego, Marcos, Sagardoy, Ainara, Martinez-Ferrandis, Jose I, Abollo-Jimenez, Fernando, Bertolo, Cristina, Peñuelas, Ivan, Garcia-Criado, Francisco J, García-Cenador, María B, Tousseyn, Thomas, Agirre, Xabier, Prosper, Felipe, Garcia-Bragado, Federico, McPhail, Ellen D, Lossos, Izidore S, Du, Ming-Qing, Flores, Teresa, Hernandez-Rivas, Jesus M, Gonzalez, Marcos, Salar, Antonio, Bellosillo, Beatriz, Conde, Eulogio, Siebert, Reiner, Sagaert, Xavier, Cobaleda, Cesar, Sanchez-Garcia, Isidro, Martinez-Climent, Jose A

“…Chromosomal translocations involving the MALT1 gene are hallmarks of mucosa-associated lymphoid tissue (MALT) lymphoma. To date, targeting these translocations…”
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LITAF, a BCL6 target gene, regulates autophagy in mature B‐cell lymphomas by Bertolo, Cristina, Roa, Sergio, Sagardoy, Ainara, Mena‐Varas, Maria, Robles, Eloy F., Martinez‐Ferrandis, Jose I., Sagaert, Xavier, Tousseyn, Thomas, Orta, Alberto, Lossos, Izidore S., Amar, Salomon, Natkunam, Yasodha, Briones, Javier, Melnick, Ari, Malumbres, Raquel, Martinez‐Climent, Jose A.

“…Summary We have previously reported that LITAF is silenced by promoter hypermethylation in germinal centre‐derived B‐cell lymphomas, but beyond these data the…”
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Abstract LB-084: Dasatinib reduces tumor growth in xenograft models derived from human lung tumors with YES1 overexpression by Garmendia, Irati, Bértolo, Cristina, Ferrer, Irene, Pajares, María J, Ajona, Daniel, Paz-Ares, Luis, Pio, Ruben, Montuenga, Luis M, Agorreta, Jackeline

“…Abstract Introduction Lung cancer accounts for 13.2% of all new cancer cases and is the leading cause of cancer-related death worldwide. For a reduction of…”
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Assessing the influence of risk factors on rates and dynamics of peripheral vein phlebitis: an observational cohort study by Mestre Roca, Gabriel, Berbel Bertolo, Cristina, Tortajada Lopez, Purificación, Gallemi Samaranch, Gema, Aguilar Ramirez, Mari Carmen, Caylà Buqueras, Joan, Rodríguez-Baño, Jesús, Martinez, José Antonio

“…To assess the influence of risk factors on the rates and kinetics of peripheral vein phlebitis (PVP) development and its theoretical influence in absolute PVP…”
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Role of bile acids and metabolic activity of colonic bacteria in increased risk of colon cancer after cholecystectomy by ZUCCATO, E, VENTURI, M, DI LEO, G, COLOMBO, L, BERTOLO, C, DOLDI, S. B, MUSSINI, E

“…Since the metabolic activity of the colonic flora plays a definite role in colon cancer and an increased incidence of this disease is reported after…”
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A model based on the quantification of complement C4c, CYFRA 21-1 and CRP exhibits high specificity for the early diagnosis of lung cancer by Ajona, Daniel, Remirez, Ana, Sainz, Cristina, Bertolo, Cristina, Gonzalez, Alvaro, Varo, Nerea, Lozano, María D, Zulueta, Javier J, Mesa-Guzman, Miguel, C Martin, Ana, Perez-Palacios, Rosa, Perez-Gracia, Jose Luis, Massion, Pierre P, Montuenga, Luis M, Pio, Ruben

“…Lung cancer screening detects early-stage cancers, but also a large number of benign nodules. Molecular markers can help in the lung cancer screening process…”
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Abstract 3989: DSTYK inhibition sensitizes lung cancer cells to immunotherapy by collapsing cytoprotective autophagy and destroying mitochondrial wellness by Valencia, Karmele, Echepare, Mirari, Pasquier, Andrea, Teijeira, Alvaro, Bertolo, Cristina, Sainz, Cristina, Bosco, Graziella, Thomas, Roman K., Agorreta, Jackeline, Lopez-Picazo, Jose Maria, Frigola, Joan, Amat, Ramon, Calvo, Alfonso, Felip, Enriqueta, Montuenga, Luis M.

“…Abstract Lung cancer is the leading cause of cancer-related death worldwide. The incidence and mortality associated to lung cancer is a major challenge of the…”
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LITAF , a BCL 6 target gene, regulates autophagy in mature B‐cell lymphomas by Bertolo, Cristina, Roa, Sergio, Sagardoy, Ainara, Mena‐Varas, Maria, Robles, Eloy F., Martinez‐Ferrandis, Jose I., Sagaert, Xavier, Tousseyn, Thomas, Orta, Alberto, Lossos, Izidore S., Amar, Salomon, Natkunam, Yasodha, Briones, Javier, Melnick, Ari, Malumbres, Raquel, Martinez‐Climent, Jose A.

“…Summary We have previously reported that LITAF is silenced by promoter hypermethylation in germinal centre‐derived B‐cell lymphomas, but beyond these data the…”
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Differences and Molecular Immunohistochemical Parameters in the Subtypes of Infiltrating Ductal Breast Cancer by BERTOLO, Cristina, GUERRERO, David, VICENTE, Francisco, CORDOBA, Alicia, ESTELLER, Manel, ROPERO, Santiago, GUILLEN-GRIMA, Francisco, MARTINEZ-PENUELA, Jose Maria, LERA, Jose Miguel

“…Breast cancer is a heterogeneous disease, and patients are categorized into subtypes according to gene expression. We studied the associations among molecular,…”
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