Search Results - "Béar, F"

A prospective study of pre-trauma risk factors for post-traumatic stress disorder and depression by Wild, J, Smith, K V, Thompson, E, Béar, F, Lommen, M J J, Ehlers, A

“…It is unclear which potentially modifiable risk factors best predict post-trauma psychiatric disorders. We aimed to identify pre-trauma risk factors for…”
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New views of Arc, a master regulator of synaptic plasticity by Shepherd, Jason D, Bear, Mark F

“…The immediate early gene product Arc has been broadly implicated in synaptic and experience-dependent plasticity. In this perspective, the authors synthesize…”
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Mutations causing syndromic autism define an axis of synaptic pathophysiology by Auerbach, Benjamin D., Osterweil, Emily K., Bear, Mark F.

“…Tuberous sclerosis complex and fragile X syndrome are genetic diseases characterized by intellectual disability and autism. Because both syndromes are caused…”
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Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities by Zoghbi, Huda Y, Bear, Mark F

“…The discovery of the genetic causes of syndromic autism spectrum disorders and intellectual disabilities has greatly informed our understanding of the…”
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Guarding Against False Positives in Qualitative Comparative Analysis by Braumoeller, Bear F.

“…The various methodological techniques that fall under the umbrella description of qualitative comparative analysis (QCA) are increasingly popular for modeling…”
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The Pathophysiology of Fragile X (and What It Teaches Us about Synapses) by BHAKAR, Asha L, DÖLEN, Gül, BEAR, Mark F

“…Fragile X is the most common known inherited cause of intellectual disability and autism, and it typically results from transcriptional silencing of FMR1 and…”
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Toward fulfilling the promise of molecular medicine in fragile X syndrome by Krueger, Dilja D, Bear, Mark F

“…Fragile X syndrome (FXS) is the most common inherited form of mental retardation and a leading known cause of autism. It is caused by loss of expression of the…”
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Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice by Michalon, Aubin, Sidorov, Michael, Ballard, Theresa M., Ozmen, Laurence, Spooren, Will, Wettstein, Joseph G., Jaeschke, Georg, Bear, Mark F., Lindemann, Lothar

“…Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. Previous studies have implicated mGlu5 in the pathogenesis of the…”
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Lovastatin Corrects Excess Protein Synthesis and Prevents Epileptogenesis in a Mouse Model of Fragile X Syndrome by Osterweil, Emily K., Chuang, Shih-Chieh, Chubykin, Alexander A., Sidorov, Michael, Bianchi, Riccardo, Wong, Robert K.S., Bear, Mark F.

“…Many neuropsychiatric symptoms of fragile X syndrome (FXS) are believed to be a consequence of altered regulation of protein synthesis at synapses. We…”
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Visual experience induces long-term potentiation in the primary visual cortex by Cooke, Sam F, Bear, Mark F

“…Stimulus-specific response potentiation (SRP) is a robust form of experience-dependent plasticity that occurs in primary visual cortex. In awake mice, visual…”
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A Cholinergic Mechanism for Reward Timing within Primary Visual Cortex by Chubykin, Alexander A., Roach, Emma B., Bear, Mark F., Shuler, Marshall G. Hussain

“…Neurons in rodent primary visual cortex (V1) relate operantly conditioned stimulus-reward intervals with modulated patterns of spiking output, but little is…”
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Hypothesis Testing and Multiplicative Interaction Terms by Braumoeller, Bear F.

“…When a statistical equation incorporates a multiplicative term in an attempt to model interaction effects, the statistical significance of the lower-order…”
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LTP and LTD: An Embarrassment of Riches by Malenka, Robert C., Bear, Mark F.

“…LTP and LTD, the long-term potentiation and depression of excitatory synaptic transmission, are widespread phenomena expressed at possibly every excitatory…”
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Reward Timing in the Primary Visual Cortex by Shuler, Marshall G, Bear, Mark F

“…We discovered that when adult rats experience an association between visual stimuli and subsequent rewards, the responses of a substantial fraction of neurons…”
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How the mechanisms of long-term synaptic potentiation and depression serve experience-dependent plasticity in primary visual cortex by Cooke, Sam F., Bear, Mark F.

“…Donald Hebb chose visual learning in primary visual cortex (V1) of the rodent to exemplify his theories of how the brain stores information through…”
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Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome by Osterweil, Emily K, Krueger, Dilja D, Reinhold, Kimberly, Bear, Mark F

“…Fragile X syndrome (FXS) is caused by loss of the FMR1 gene product FMRP (fragile X mental retardation protein), a repressor of mRNA translation. According to…”
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The mGluR theory of fragile X mental retardation by Bear, Mark F, Huber, Kimberly M, Warren, Stephen T

“…Many of the diverse functional consequences of activating group 1 metabotropic glutamate receptors require translation of pre-existing mRNA near synapses. One…”
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The Autistic Neuron: Troubled Translation? by Kelleher, Raymond J., Bear, Mark F.

“…Autism is a complex genetic disorder, but single-gene disorders with a high prevalence of autism offer insight into its pathogenesis. Recent evidence suggests…”
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Learning Induces Long-Term Potentiation in the Hippocampus by Whitlock, Jonathan R, Heynen, Arnold J, Shuler, Marshall G, Bear, Mark F

“…Years of intensive investigation have yielded a sophisticated understanding of long-term potentiation (LTP) induced in hippocampal area CA1 by high-frequency…”
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Food scarcity and state vulnerability: Unpacking the link between climate variability and violent unrest by Jones, Benjamin T, Mattiacci, Eleonora, Braumoeller, Bear F

“…Increased scholarly focus on climate variability and its implications has given rise to a substantial literature on the relationship between climate-induced…”
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