Search Results - "Bäuml, A."
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Conformational μ‑Conotoxin PIIIA Isomers Revisited: Impact of Cysteine Pairing on Disulfide-Bond Assignment and Structure Elucidation
Published in Analytical chemistry (Washington) (06-03-2018)“…Peptides and proteins carrying high numbers of cysteines can adopt various 3D structures depending on their disulfide connectivities. The unambiguous…”
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Coagulation Factor XIIIa Inhibitor Tridegin: On the Role of Disulfide Bonds for Folding, Stability, and Function
Published in Journal of medicinal chemistry (11-04-2019)“…Tridegin is a potent and specific 66mer peptide inhibitor of coagulation factor XIIIa with six cysteines involved in three disulfide bonds. Three of the 15…”
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Novel Insights into Structure and Function of Factor XIIIa-Inhibitor Tridegin
Published in Journal of medicinal chemistry (26-12-2014)“…The inhibition of the final step in blood coagulation, the factor XIIIa (FXIIIa) catalyzed cross-linking of fibrin monomers, is currently still a challenge in…”
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Inhibitors of blood coagulation factor XIII
Published in Analytical biochemistry (15-09-2020)“…The blood coagulation factor XIII (FXIII) plays an essential role in the stabilization of fibrin clots. This factor, belonging to the class of…”
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Mast cell–derived factor XIIIA contributes to sexual dimorphic defense against group B streptococcal infections
Published in The Journal of clinical investigation (15-10-2022)“…Invasive bacterial infections remain a major cause of human morbidity. Group B streptococcus (GBS) are Gram-positive bacteria that cause invasive infections in…”
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Distinct 3-disulfide-bonded isomers of tridegin differentially inhibit coagulation factor XIIIa: The influence of structural stability on bioactivity
Published in European journal of medicinal chemistry (01-09-2020)“…Tridegin is a 66mer cysteine-rich coagulation factor XIIIa (FXIIIa) inhibitor from the giant amazon leech Haementeria ghilianii of yet unknown disulfide…”
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NMR-Based Structural Characterization of a Two-Disulfide-Bonded Analogue of the FXIIIa Inhibitor Tridegin: New Insights into Structure-Activity Relationships
Published in International journal of molecular sciences (17-01-2021)“…The saliva of blood-sucking leeches contains a plethora of anticoagulant substances. One of these compounds derived from , the 66mer three-disulfide-bonded…”
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Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
Published in Journal of visualized experiments (02-10-2018)“…Peptides with a high number of cysteines are usually influenced regarding the three-dimensional structure by their disulfide connectivity. It is thus highly…”
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Impact of Stress Cardiac Magnetic Resonance Imaging on Clinical Care
Published in The American journal of cardiology (15-09-2016)“…Abstract Given the rising costs of imaging, there is increasing pressure to provide evidence for direct additive impact on clinical care. Appropriate use…”
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Radiation dose and image quality in spiral computed tomography: multicentre evaluation at six institutions
Published in British journal of radiology (01-07-1998)“…The purpose of this study was to evaluate the correlation of radiation dose with image quality in spiral CT. Seven clinical protocols were measured in six…”
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Comparison of Cardiac Magnetic Resonance and Computed Tomography Stress-Rest Perfusion Imaging for Detection of Coronary Artery Disease
Published in Journal of the American College of Cardiology (23-07-2013)“…For this reason, areas of LGE in an infarct pattern are typically interpreted as demonstrating the presence of CAD (2,3). Because ~16% of the patients in this…”
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Radiation dose and image quality in spiral computed tomography : Results of a multicentre study at eight radiological institutions
Published in Radiation protection dosimetry (1998)“…An overview is presented of a project enacted to help assess radiation dose with respect to image quality. As part of these efforts, seven clinical protocols…”
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Mammoth ventricular hypertrophy
Published in Circulation (New York, N.Y.) (03-02-2015)Get full text
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Left ventricular hypertrophy: an overlooked cardiovascular risk factor
Published in Cleveland Clinic journal of medicine (01-06-2010)“…Left ventricular hypertrophy (LVH) is common in hypertensive patients, and it increases the risk of myocardial infarction, stroke, and death. Recent evidence…”
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Downstream clinical consequences of stress cardiovascular magnetic resonance based on appropriate use criteria
Published in Journal of cardiovascular magnetic resonance (15-05-2015)“…Appropriate use criteria (AUC) have been developed by professional organizations as a response to the rising costs of imaging, with the goal of optimizing…”
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Assessment of global myocardial perfusion reserve using cardiovascular magnetic resonance of coronary sinus flow at 3 Tesla
Published in Journal of cardiovascular magnetic resonance (27-03-2014)“…Despite increasing clinical use, there is limited data regarding regadenoson in stress perfusion cardiovascular magnetic resonance (CMR). In particular, given…”
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Palpitations in a 64-year-old man
Published in Heart (British Cardiac Society) (01-01-2014)“…A 64-year-old man presented with several weeks of intermittent irregular palpitations. He had no prior history of cardiac disease, hypertension or syncope. A…”
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Paging the Clinical Informatics Community: Respond STAT to Dobbs v. Jackson's Women's Health Organization
Published in Applied clinical informatics (01-01-2023)Get full text
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