Search Results - "Bäumer, Nicole"

Antibody-mediated delivery of anti-KRAS-siRNA in vivo overcomes therapy resistance in colon cancer by Bäumer, Sebastian, Bäumer, Nicole, Appel, Neele, Terheyden, Lisa, Fremerey, Julia, Schelhaas, Sonja, Wardelmann, Eva, Buchholz, Frank, Berdel, Wolfgang E, Müller-Tidow, Carsten

“…KRAS mutations are frequent driver mutations in multiple cancers. KRAS mutations also induce anti-EGFR antibody resistance in adenocarcinoma such as colon…”
Get full text

Immunoprotein-Mediated siRNA Delivery by Bäumer, Nicole, Berdel, Wolfgang E, Bäumer, Sebastian

“…RNA interference strategies offer an alternative to small molecular drug targeting. Small interfering RNA (siRNA) constitutes a class of molecules that allows…”
Get full text

Antibody-coupled siRNA as an efficient method for in vivo mRNA knockdown by Bäumer, Nicole, Appel, Neele, Terheyden, Lisa, Buchholz, Frank, Rossig, Claudia, Müller-Tidow, Carsten, Berdel, Wolfgang E, Bäumer, Sebastian

“…This virus-free approach for mRNA knockdown in vivo uses the siRNA carrier peptide protamine, chemically coupled to a cell surface receptor internalizing…”
Get full text

Microfluidic-Based Detection of AML-Specific Biomarkers Using the Example of Promyelocyte Leukemia by Emde, Benedikt, Kreher, Heike, Bäumer, Nicole, Bäumer, Sebastian, Bouwes, Dominique, Tickenbrock, Lara

“…A microfluidic assay for the detection of promyelocytic leukemia (PML)-retinoic acid receptor α (RARα) fusion protein was developed. This microfluidic-based…”
Get full text

Downregulation of PIK3CA via antibody-esiRNA-complexes suppresses human xenograft tumor growth by Bäumer, Nicole, Rehkämper, Jan, Appel, Neele, Terheyden, Lisa, Hartmann, Wolfgang, Wardelmann, Eva, Buchholz, Frank, Müller-Tidow, Carsten, Berdel, Wolfgang E, Bäumer, Sebastian

“…Precision cancer therapy requires on the one hand detailed knowledge about a tumor's driver oncogenes and on the other hand an effective targeted therapy that…”
Get full text

Electrostatic anti-CD33-antibody-protamine nanocarriers as platform for a targeted treatment of acute myeloid leukemia by Bäumer, Nicole, Scheller, Annika, Wittmann, Lisa, Faust, Andreas, Apel, Mara, Nimmagadda, Subbaiah Chary, Geyer, Christiane, Grunert, Katharina, Kellmann, Neele, Peipp, Matthias, Kailayangiri, Sareetha, Gutierrez Suburu, Matias Ezequiel, Strassert, Cristian A, Schenk, Mathias, Greune, Lilo, Rüter, Christian, Dersch, Petra, Hartmann, Wolfgang, Rossig, Claudia, Neri, Dario, Müller-Tidow, Carsten, Schwöppe, Christian, Schliemann, Christoph, Khandanpour, Cyrus, Lenz, Georg, Berdel, Wolfgang E, Bäumer, Sebastian

“…Acute myeloid leukemia (AML) is a fatal clonal hematopoietic malignancy, which results from the accumulation of several genetic aberrations in myeloid…”
Get full text

Proteinase-Activated Receptor 1 (PAR1) regulates leukemic stem cell functions by Bäumer, Nicole, Krause, Annika, Köhler, Gabriele, Lettermann, Stephanie, Evers, Georg, Hascher, Antje, Bäumer, Sebastian, Berdel, Wolfgang E, Müller-Tidow, Carsten, Tickenbrock, Lara

“…External signals that are mediated by specific receptors determine stem cell fate. The thrombin receptor PAR1 plays an important role in haemostasis,…”
Get full text

Genome-wide analysis of histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene by Agrawal-Singh, Shuchi, Isken, Fabienne, Agelopoulos, Konstantin, Klein, Hans-Ulrich, Thoennissen, Nils H., Koehler, Gabriele, Hascher, Antje, Bäumer, Nicole, Berdel, Wolfgang E., Thiede, Christian, Ehninger, Gerhard, Becker, Anke, Schlenke, Peter, Wang, Yipeng, McClelland, Michael, Krug, Utz, Koschmieder, Steffen, Büchner, Thomas, Yu, Dae-Yeul, Singh, Shailendra Vikram, Hansen, Klaus, Serve, Hubert, Dugas, Martin, Müller-Tidow, Carsten

“…With the use of ChIP on microarray assays in primary leukemia samples, we report that acute myeloid leukemia (AML) blasts exhibit significant alterations in…”
Get full text

Hotspot DNMT3A mutations in clonal hematopoiesis and acute myeloid leukemia sensitize cells to azacytidine via viral mimicry response by Scheller, Marina, Ludwig, Anne Kathrin, Göllner, Stefanie, Rohde, Christian, Krämer, Stephen, Stäble, Sina, Janssen, Maike, Müller, James-Arne, He, Lixiazi, Bäumer, Nicole, Arnold, Christian, Gerß, Joachim, Schönung, Maximilian, Thiede, Christian, Niederwieser, Christian, Niederwieser, Dietger, Serve, Hubert, Berdel, Wolfgang E, Thiem, Ulrich, Hemmerling, Inga, Leuschner, Florian, Plass, Christoph, Schlesner, Matthias, Zaugg, Judith, Milsom, Michael D, Trumpp, Andreas, Pabst, Caroline, Lipka, Daniel B, Müller-Tidow, Carsten

“…Somatic mutations in DNA methyltransferase 3A (DNMT3A) are among the most frequent alterations in clonal hematopoiesis (CH) and acute myeloid leukemia (AML),…”
Get full text

Intravenous Iron Carboxymaltose as a Potential Therapeutic in Anemia of Inflammation by Lofruthe, Niklas, Gallitz, Inka, Traeger, Lisa, Bäumer, Nicole, Schulze, Isabell, Kuhlmann, Tanja, Müller-Tidow, Carsten, Steinbicker, Andrea U

“…Intravenous iron supplementation is an effective therapy in iron deficiency anemia (IDA), but controversial in anemia of inflammation (AI). Unbound iron can be…”
Get full text

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells by Schemionek, Mirle, Elling, Christian, Steidl, Ulrich, Bäumer, Nicole, Hamilton, Ashley, Spieker, Tilmann, Göthert, Joachim R., Stehling, Martin, Wagers, Amy, Huettner, Claudia S., Tenen, Daniel G., Tickenbrock, Lara, Berdel, Wolfgang E., Serve, Hubert, Holyoake, Tessa L., Müller-Tidow, Carsten, Koschmieder, Steffen

“…In a previously developed inducible transgenic mouse model of chronic myeloid leukemia, we now demonstrate that the disease is transplantable using BCR-ABL+…”
Get full text

Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6 by Bäumer, Nicole, Marquardt, Till, Stoykova, Anastassia, Spieler, Derek, Treichel, Dieter, Ashery-Padan, Ruth, Gruss, Peter

“…The transcription factors Pax2 and Pax6 are co-expressed in the entire optic vesicle (OV) prior and concomitant with the establishment of distinct…”
Get full text

MYST2 acetyltransferase expression and Histone H4 Lysine acetylation are suppressed in AML by Sauer, Tim, Arteaga, Maria Francisca, Isken, Fabienne, Rohde, Christian, Hebestreit, Katja, Mikesch, Jan-Henrik, Stelljes, Matthias, Cui, Chunhong, Zhou, Fengbiao, Göllner, Stefanie, Bäumer, Nicole, Köhler, Gabriele, Krug, Utz, Thiede, Christian, Ehninger, Gerhard, Edemir, Bayram, Schlenke, Peter, Berdel, Wolfgang E, Dugas, Martin, Müller-Tidow, Carsten

“…Chromatin-modifying enzymes are frequently altered in acute myeloid leukemia (AML). In the current study, we identified MYST2, a core histone…”
Get full text

Direct and concentration-dependent regulation of the proneural gene Neurogenin2 by Pax6 by Scardigli, Raffaella, Bäumer, Nicole, Gruss, Peter, Guillemot, François, Le Roux, Isabelle

“…Expression of the proneural gene Neurogenin2 is controlled by several enhancer elements, with the E1 element active in restricted progenitor domains in the…”
Get full text

The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects by Zhang, Feng, Bäumer, Nicole, Rode, Miriam, Ji, Ping, Zhang, Tao, Berdel, Wolfgang E, Müller-Tidow, Carsten

“…The proteins of the Inhibitor of Growth (ING) family are involved in multiple cellular functions such as cell cycle regulation, apoptosis, and chromatin…”
Get full text

A Limited Role for the Cell Cycle Regulator Cyclin A1 in Murine Leukemogenesis by Bäumer, Nicole, Bäumer, Sebastian, Haak, Miriam, Koschmieder, Steffen, Schönig, Kai, Berdel, Wolfgang E, Müller-Tidow, Carsten

“…The quest for novel therapeutic targets in acute myeloid leukemia (AML) is still ongoing. One of such targets, cyclin A1, was shown to be overexpressed in AML…”
Get full text

Maintenance of leukemia-initiating cells is regulated by the CDK inhibitor Inca1 by Bäumer, Nicole, Bäumer, Sebastian, Berkenfeld, Frank, Stehling, Martin, Köhler, Gabriele, Berdel, Wolfgang E, Müller-Tidow, Carsten, Tschanter, Petra

“…Functional differences between healthy progenitor and cancer initiating cells may provide unique opportunities for targeted therapy approaches. Hematopoietic…”
Get full text

Psychopharmacological treatments in Down syndrome and autism spectrum disorder: State of the research and practical considerations by Baumer, Nicole T., Capone, George

“…Individuals with Down syndrome (DS) or Autism Spectrum Disorder (ASD), and especially those with both DS and co‐occurring ASD (DS + ASD) commonly display…”
Get full text

DNMT3B Expression Delays Leukemogenesis by Tschanter, Petra, Schulze, Isabell, Bäumer, Nicole, Surmann, Beate, Agelopoulos, Konstantin, Krug, Utz, Berdel, Wolfgang E., Linhart, Heinz, Müller-Tidow, Carsten

“…Abstract 3446 Acute myeloid leukaemia (AML) is a malignant disease with poor prognosis, which is, among other biological features, characterized by epigenetic…”
Get full text

Cyclin A1, the alternative A-type cyclin, contributes to G1 S cell cycle progression in somatic cells by PING JI, AGRAWAL, Shuchi, SERVE, Hubert, MÜLLER-TIDOW, Carsten, DIEDERICHS, Sven, BÄUMER, Nicole, BECKER, Annette, CAUVET, Thomas, KOWSKI, Sascha, BEGER, Carmela, WELTE, Karl, BERDEL, Wolfgang E

“…Cyclin A1 is an alternative A-type cyclin that is essential for spermatogenesis, but it is also expressed in hematopoietic progenitor cells and in acute…”
Get full text