Search Results - "Bär, P.R"

Willem Hendrik Gispen – An interview by Bär, P.R.

“…This text is based on three long interviews in Utrecht University′s Faculty Club, and on almost 40 years of working together in the same city, the same…”
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Sexual differences in onset of disease and response to exercise in a transgenic model of ALS by Veldink, J.H., Bär, P.R., Joosten, E.A.J., Otten, M., Wokke, J.H.J., van den Berg, L.H.

“…Transgenic mice that overexpress the mutant human SOD1 gene (hSOD1) serve as an animal model for amyotrophic lateral sclerosis (ALS). Age and sex are…”
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Delayed decompressive surgery increases apparent diffusion coefficient and improves peri-infarct perfusion in rats with space-occupying cerebral infarction by HOFMEIJER, J, SCHEPERS, J, VELDHUIS, W. B, NICOLAY, K, KAPPELLE, L. J, BÄR, P. R, VAN DER WORP, H. B

“…There is no conclusive experimental support that decompressive surgery in late stages of space-occupying cerebral infarction will improve outcome. We studied…”
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Zinc amplifies mSOD1-mediated toxicity in a transgenic mouse model of amyotrophic lateral sclerosis by Groeneveld, G.J., de Leeuw van Weenen, J., van Muiswinkel, F.L., Veldman, H., Veldink, J.H., Wokke, J.H.J., Bär, P.R., van den Berg, L.H.

“…Transgenic mice overexpressing the human mutated form (G93A) of Cu,Zn-superoxide dismutase (mSOD1) develop motor neuron degeneration resembling amyotrophic…”
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Dietary vitamin E levels affect outcome of permanent focal cerebral ischemia in rats by van der Worp, H B, Bär, P R, Kappelle, L J, de Wildt, D J

“…A supraphysiological amount of vitamin E in the standard diet of laboratory animals may provide partial protection against cerebral ischemic damage in stroke…”
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Differential cortico-motoneuron vulnerability after chronic mitochondrial inhibition in vitro and the role of glutamate receptors by Van Westerlaak, M.G.H, Joosten, E.A.J, Gribnau, A.A.M, Cools, A.R, Bär, P.R

“…Chronic treatment of rat cortical slices with a relative low concentration of mitochondrial inhibitor malonate leads to cortical motoneuron (CMN) death. In the…”
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Activation of the sarcoplasmic reticulum Ca2+-ATPase induced by exercise by Ferrington, D A, Reijneveld, J C, Bär, P R, Bigelow, D J

“…Prolonged exercise has been shown to cause disruption of intracellular calcium homeostasis in skeletal muscle, which is normally maintained by the sarcoplasmic…”
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Prevention of exercise-induced muscle membrane damage by oestradiol by Bär, P R, Amelink, G J, Oldenburg, B, Blankenstein, M A

“…Exercise can damage the muscle membrane, followed by leakage of certain muscle proteins into the bloodstream. This postexercise response differs for males and…”
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Stimulation by melanocortins of neurite outgrowth from spinal and sensory neurons in vitro by van der Neut, R, Hol, E M, Gispen, W H, Bär, P R

“…Using ELISAs for B-50/GAP43 and neurofilament (NF), we tested ACTH(1-24), alpha-MSH, ACTH(4-10), and an ACTH(4-9) analogue (ORG2766) for their ability to…”
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Indications for an immune-mediated etiology of idiopathic sensory neuronopathy by van Dijk, Gert W, Wokke, John H.J, Notermans, Nicolette C, van den Berg, Leonard H, Bär, P.R

“…To investigate immune mechanisms in the etiology of idiopathic sensory neuronopathy (ISN), we studied neurite outgrowth inhibition and antibody binding to…”
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phosphatidylinositol transfer protein α-dependent survival factor protects cultured primary neurons against serum deprivation-induced cell death by Bunte, Hanneke, Schenning, Martijn, Sodaar, Peter, Bär, Dop P.R, Wirtz, Karel W.A, Van Muiswinkel, Freek L, Snoek, Gerry T

“…Selective neuronal loss is a prominent feature in both acute and chronic neurological disorders. Recently, a link between neurodegeneration and a deficiency in…”
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Nimodipine protects cultured spinal cord neurones from depolarization-induced inhibition of neurite outgrowth by Bär, P R, Renkema, G H, Veraart, C M, Hol, E M, Gispen, W H

“…In the nervous system calcium ions play a crucial role in the regulation of growth cone motility, cell migration and neurite outgrowth. High intracellular Ca2+…”
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Collagen Containing Neurotrophin-3 (NT-3) Attracts Regrowing Injured Corticospinal Axons in the Adult Rat Spinal Cord and Promotes Partial Functional Recovery by Houweling, D.A., Lankhorst, A.J., Gispen, W.H., Bär, P.R., Joosten, E.A.J.

“…During development, neurotrophic factors play an important role in the guidance and outgrowth of axons. Our working hypothesis is that neurotrophic factors…”
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Ovariectomy and 17β-estradiol modulate disease progression of a mouse model of ALS by Groeneveld, G.J., Van Muiswinkel, F.L., Sturkenboom, J.M., Wokke, J.H.J., Bär, P.R., Van den Berg, L.H.

“…The incidence of amyotrophic lateral sclerosis (ALS) is higher among men than women but rises in women after the menopause. Estrogens may play a protective…”
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Progress testing with short answer questions by Rademakers, J., ten Cate, Th. J., Bär, P.R.

“…The concept of progress testing was developed in the 1970s. Significant features of progress tests are that the content is not linked to any specific course or…”
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Motor neuron disease in vitro: the use of cultured motor neurons to study amyotrophic lateral sclerosis by Bär, P.R

“…Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease in which motor neurons in the nervous system die. The cause is unknown, and no…”
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Intraspinal administration of an antibody against CD81 enhances functional recovery and tissue sparing after experimental spinal cord injury by Dijkstra, S., Duis, S., Pans, I.M., Lankhorst, A.J., Hamers, F.P.T., Veldman, H., Bär, P.R., Gispen, W.H., Joosten, E.A.J., Geisert, E.E.

“…We previously demonstrated that the tetraspanin protein CD81 is up-regulated by astrocytes and microglia after traumatic spinal cord injury in rats and that…”
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Cardiopulmonary bypass and long-term neurocognitive dysfunction in the rat by Dieleman, Jan M., de Lange, Fellery, Houston, Ralph J.F., Biessels, Geert-Jan, Bär, P.R., Mackensen, G. Burkhard, Grocott, Hilary P., Kalkman, Cor J.

“…Neurologic and neurocognitive complications after cardiac surgery with cardiopulmonary bypass (CPB) have been reported repeatedly. To better understand its…”
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The time course of ischemic damage and cerebral perfusion in a rat model of space-occupying cerebral infarction by Hofmeijer, J, Veldhuis, W.B, Schepers, J, Nicolay, K, Kappelle, L.J, Bär, P.R, van der Worp, H.B

“…We aimed to establish a rat model of space-occupying hemispheric infarction to evaluate potential treatment strategies. For adequate timing of therapy in…”
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Apoptosis — the cell's silent exit by Bär, P.R.

“…Apo-ptosis, derived from Greek for 'falling off, can refer to the falling off of leaves during autumn (1), but is currently often used to describe a particular…”
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