Search Results - "Bähr, M."

ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS by Koch, J C, Tönges, L, Barski, E, Michel, U, Bähr, M, Lingor, P

“…The Rho/ROCK/LIMK pathway is central for the mediation of repulsive environmental signals in the central nervous system. Several studies using pharmacological…”
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From systems medicine to personalized neurology by Bähr, M

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Human synapsin 1 gene promoter confers highly neuron-specific long-term transgene expression from an adenoviral vector in the adult rat brain depending on the transduced area by KÜGLER, S, KILIC, E, BÄHR, M

“…Targeting therapeutic transgene expression to defined tissues is a major task in the development of safe and efficient gene therapy protocols. Recombinant…”
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Alpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons by Koch, J C, Bitow, F, Haack, J, d'Hedouville, Z, Zhang, J-N, Tönges, L, Michel, U, Oliveira, L M A, Jovin, T M, Liman, J, Tatenhorst, L, Bähr, M, Lingor, P

“…Many neuropathological and experimental studies suggest that the degeneration of dopaminergic terminals and axons precedes the demise of dopaminergic neurons…”
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Vbfnlo: A parton level Monte Carlo for processes with electroweak bosons by Arnold, K., Bähr, M., Bozzi, G., Campanario, F., Englert, C., Figy, T., Greiner, N., Hackstein, C., Hankele, V., Jäger, B., Klämke, G., Kubocz, M., Oleari, C., Plätzer, S., Prestel, S., Worek, M., Zeppenfeld, D.

“…Vbfnlo is a fully flexible parton level Monte Carlo program for the simulation of vector boson fusion, double and triple vector boson production in hadronic…”
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Extracellular Vesicles Derived from Neural Progenitor Cells––a Preclinical Evaluation for Stroke Treatment in Mice by Zheng, X., Zhang, L., Kuang, Y., Venkataramani, V., Jin, F., Hein, K., Zafeiriou, M. P., Lenz, C., Moebius, W., Kilic, E., Hermann, D. M., Weber, M. S., Urlaub, H., Zimmermann, W.-H., Bähr, M., Doeppner, Thorsten R.

“…Stem cells such as mesenchymal stem cells (MSCs) enhance neurological recovery in preclinical stroke models by secreting extracellular vesicles (EVs). Since…”
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The upregulation of GLAST-1 is an indirect antiapoptotic mechanism of GDNF and neurturin in the adult CNS by Koeberle, P D, Bähr, M

“…Glial cell-line-derived neurotrophic factor (GDNF) and neurturin (NTN) protect retinal ganglion cells (RGCs) from axotomy-induced apoptosis. It is likely that…”
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Promoters and serotypes: targeting of adeno-associated virus vectors for gene transfer in the rat central nervous system in vitro and in vivo by Shevtsova, Z, Malik, J M I, Michel, U, Bähr, M, Kügler, S

“…The brain parenchyma consists of several different cell types, such as neurones, astrocytes, microglia, oligodendroglia and epithelial cells, which are…”
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Vasoactive intestinal peptide, whose receptor-mediated signalling may be defective in alopecia areata, provides protection from hair follicle immune privilege collapse by Bertolini, M., Pretzlaff, M., Sulk, M., Bähr, M., Gherardini, J., Uchida, Y., Reibelt, M., Kinori, M., Rossi, A., Bíró, T., Paus, R.

“…Summary Background Alopecia areata (AA) is an autoimmune disorder whose pathogenesis involves the collapse of the relative immune privilege (IP) of the hair…”
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Effects of acute versus post-acute systemic delivery of neural progenitor cells on neurological recovery and brain remodeling after focal cerebral ischemia in mice by Doeppner, T R, Kaltwasser, B, Teli, M K, Bretschneider, E, Bähr, M, Hermann, D M

“…Intravenous transplantation of neural progenitor cells (NPCs) induces functional recovery after stroke, albeit grafted cells are not integrated into residing…”
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Cellular prion protein promotes post-ischemic neuronal survival, angioneurogenesis and enhances neural progenitor cell homing via proteasome inhibition by Doeppner, T R, Kaltwasser, B, Schlechter, J, Jaschke, J, Kilic, E, Bähr, M, Hermann, D M, Weise, J

“…Although cellular prion protein (PrP c ) has been suggested to have physiological roles in neurogenesis and angiogenesis, the pathophysiological relevance of…”
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Live or let die – retinal ganglion cell death and survival during development and in the lesioned adult CNS by Bahr, Mathias

“…Programmed cell death or apoptosis is a common and widespread phenomenon that is important for proper development of the nervous system. In the adult CNS,…”
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Identification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screen by Loh, S H Y, Francescut, L, Lingor, P, Bähr, M, Nicotera, P

“…Disruption of synaptic integrity, loss of connectivity and axodendritic degeneration are early and essential components of neurodegeneration. Although neuronal…”
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Differential transgene expression in brain cells in vivo and in vitro from AAV-2 vectors with small transcriptional control units by Kügler, S, Lingor, P, Schöll, U, Zolotukhin, S, Bähr, M

“…Adeno-associated- (AAV) based vectors are promising tools for gene therapy applications in several organs, including the brain, but are limited by their small…”
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Neuroprotective effects and intracellular signaling pathways of erythropoietin in a rat model of multiple sclerosis by Sättler, M B, Merkler, D, Maier, K, Stadelmann, C, Ehrenreich, H, Bähr, M, Diem, R

“…In multiple sclerosis (MS), long-term disability is primarily caused by axonal and neuronal damage. We demonstrated in a previous study that neuronal apoptosis…”
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Correction to: Extracellular Vesicles Derived from Neural Progenitor Cells––a Preclinical Evaluation for Stroke Treatment in Mice by Zheng, X., Zhang, L., Kuang, Y., Venkataramani, V., Jin, F., Hein, K., Zafeiriou, M. P., Lenz, C., Moebius, W., Kilic, E., Hermann, D. M., Weber, M. S., Urlaub, H., Zimmermann, W.-H., Bähr, M., Doeppner, Thorsten R.

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Overview of the yeast genome. [Erratum: June 12, 1997, v. 387 (6634), p. 737.] by Mewes, H.W, Albermann, K, Bahr, M, Frishman, D, Gleissner, A, Hani, J, Heumann, K, Kleine, K, Maierl, A, Oliver, S.G

“…The collaboration of more than 600 scientists from over 100 laboratories to sequence the Saccharomyces cerevisiae genome was the largest decentralised…”
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Proinflammatory cell stress in sporadic inclusion body myositis muscle: overexpression of αB-crystallin is associated with amyloid precursor protein and accumulation of β-amyloid by Muth, I E, Barthel, K, Bähr, M, Dalakas, M C, Schmidt, J

“…Background:In the pathology of sporadic inclusion body myositis (sIBM), the relevance of cell stress molecules such as the heat shock protein αB-crystallin,…”
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Insulin-Like Growth Factor-I Protects Axotomized Rat Retinal Ganglion Cells from Secondary Death via PI3-K-Dependent Akt Phosphorylation and Inhibition of Caspase-3 In Vivo by Kermer, Pawel, Klocker, Nikolaj, Labes, Monika, Bahr, Mathias

“…Recently we have shown that the majority of retinal ganglion cells (RGCs) dies via activation of caspase-3 after transection of the optic nerve (ON) in the…”
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The c-Jun transcription factor – bipotential mediator of neuronal death, survival and regeneration by Herdegen, Thomas, Skene, Pate, Bähr, Mathias

“…Axon interruption elicits a complex neuronal response that leaves neurons poised precariously between death and regeneration. The signals underlying this…”
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