Search Results - "Bäcklund, L Magnus"

Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas by Jones, David T W, Kocialkowski, Sylvia, Liu, Lu, Pearson, Danita M, Bäcklund, L Magnus, Ichimura, Koichi, Collins, V Peter

“…Brain tumors are the most common solid tumors of childhood, and pilocytic astrocytomas (PA) are the most common central nervous system tumor in 5 to 19 year…”
Get full text

IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas by Ichimura, Koichi, Pearson, Danita M, Kocialkowski, Sylvia, Bäcklund, L Magnus, Chan, Raymond, Jones, David T W, Collins, V Peter

“…We screened exon 4 of the gene isocitrate dehydrogenase 1 (NADP+), soluble (IDH1) for mutations in 596 primary intracranial tumors of all major types. Codon…”
Get full text

Molecular profiling of long-term survivors identifies a subgroup of glioblastoma characterized by chromosome 19/20 co-gain by Geisenberger, Christoph, Mock, Andreas, Warta, Rolf, Rapp, Carmen, Schwager, Christian, Korshunov, Andrey, Nied, Ann-Katrin, Capper, David, Brors, Benedikt, Jungk, Christine, Jones, David, Collins, V. Peter, Ichimura, Koichi, Bäcklund, L. Magnus, Schnabel, Elena, Mittelbron, Michel, Lahrmann, Bernd, Zheng, Siyuan, Verhaak, Roel G. W., Grabe, Niels, Pfister, Stefan M., Hartmann, Christian, von Deimling, Andreas, Debus, Jürgen, Unterberg, Andreas, Abdollahi, Amir, Herold-Mende, Christel

“…Glioblastoma (GBM) is a devastating tumor and few patients survive beyond 3 years. Defining the molecular determinants underlying long-term survival is…”
Get full text

MGMT CpG island is invariably methylated in adult astrocytic and oligodendroglial tumors with IDH1 or IDH2 mutations by Mulholland, Shani, Pearson, Danita M., Hamoudi, Rifat A., Malley, Deborah S., Smith, Caroline M., Weaver, Jamie M.J., Jones, David T.W., Kocialkowski, Sylvia, Bäcklund, L. Magnus, Collins, V. Peter, Ichimura, Koichi

“…We have previously identified a region containing 16 CpGs within the MGMT CpG islands which is critical for the transcriptional control of MGMT (Malley, Acta…”
Get full text

Survival and level of care among breast cancer patients with brain metastases treated with whole brain radiotherapy by Frisk, Gabriella, Tinge, Beatrice, Ekberg, Sara, Eloranta, Sandra, Bäcklund, L. Magnus, Lidbrink, Elisabet, Smedby, Karin E.

“…Purpose The benefit of whole brain radiotherapy (WBRT) for late stage breast cancer patients with brain metastases has been questioned. In this study we…”
Get full text

Distinct patterns of 1p and 19q alterations identify subtypes of human gliomas that have different prognoses by Vogazianou, Artemis P., Chan, Raymond, Bäcklund, L. Magnus, Pearson, Danita M., Liu, Lu, Langford, Cordelia F., Gregory, Simon G., Collins, V. Peter, Ichimura, Koichi

“…We studied the status of chromosomes 1 and 19 in 363 astrocytic and oligodendroglial tumors. Whereas the predominant pattern of copy number abnormality was a…”
Get full text

High-Resolution Array-Based Comparative Genomic Hybridization of Medulloblastomas and Supratentorial Primitive Neuroectodermal Tumors by McCabe, Martin Gerard, Ichimura, Koichi, Liu, Lu, Plant, Karen, Bäcklund, L. Magnus, Pearson, Danita M, Collins, Vincent Peter

“…Medulloblastomas and supratentorial primitive neuroectodermal tumors are aggressive childhood tumors. We report our findings using array comparative genomic…”
Get full text

Clinical significance of EGFR amplification and the aberrant EGFRvIII transcript in conventionally treated astrocytic gliomas by LU LIU, BÄCKLUND, L. Magnus, NILSSON, Bo R, GRANDER, Dan, ICHIMURA, Koichi, GOIKE, Helena M, COLLINS, V. Peter

“…The aim of this study was to evaluate the clinical value of assessing epidermal growth factor receptor (EGFR) amplification and the common 5' rearrangement of…”
Get full text

Adult grade II diffuse astrocytomas are genetically distinct from and more aggressive than their paediatric counterparts by Jones, David T. W., Mulholland, Shani A., Pearson, Danita M., Malley, Deborah S., Openshaw, Samuel W. S., Lambert, Sally R., Liu, Lu, Bäcklund, L. Magnus, Ichimura, Koichi, Collins, V. Peter

“…Diffuse astrocytomas (WHO grade II) typically present as slow-growing tumours showing significant cellular differentiation, but possessing a tendency towards…”
Get full text

Growth factor receptors signaling in glioblastoma cells: therapeutic implications by Carapancea, Mia, Alexandru, Oana, Fetea, Ani S., Dragutescu, Laura, Castro, Juan, Georgescu, Ada, Popa-Wagner, A., Bäcklund, Magnus L., Lewensohn, Rolf, Dricu, Anica

“…In this study, we investigated the protein expression of platelet-derived growth factor receptor (PDGFR), insulin like growth factor-1 receptor (IGF-1R),…”
Get full text

Short Postoperative Survival for Glioblastoma Patients with a Dysfunctional Rb1 Pathway in Combination with No Wild-type PTEN by MAGNUS BÄCKLUND, L, NILSSON, Bo R, GOIKE, Helena M, SCHMIDT, Esther E, LU LIU, ICHIMURA, Koichi, COLLINS, V. Peter

“…Purpose: Glioblastoma (GB, WHO grade IV) is the most common primary brain tumor in adults. Survival is typically <1 year but varies between a few months and a…”
Get full text

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas by Kool, Marcel, Korshunov, Andrey, Remke, Marc, Jones, David T. W., Schlanstein, Maria, Northcott, Paul A., Cho, Yoon-Jae, Koster, Jan, Schouten-van Meeteren, Antoinette, van Vuurden, Dannis, Clifford, Steven C., Pietsch, Torsten, von Bueren, Andre O., Rutkowski, Stefan, McCabe, Martin, Collins, V. Peter, Bäcklund, Magnus L., Haberler, Christine, Bourdeaut, Franck, Delattre, Olivier, Doz, Francois, Ellison, David W., Gilbertson, Richard J., Pomeroy, Scott L., Taylor, Michael D., Lichter, Peter, Pfister, Stefan M.

“…Medulloblastoma is the most common malignant brain tumor in childhood. Molecular studies from several groups around the world demonstrated that medulloblastoma…”
Get full text

Helianthin induces antiproliferative effect on human glioblastoma cells in vitro by Alexandru, Oana, Dragutescu, Laura, Tataranu, Ligia, Ciubotaru, Vasile, Sevastre, Ani, Georgescu, Ada Maria, Purcaru, Oana, Danoiu, Suzana, Bäcklund, L. Magnus, Dricu, Anica

“…A major focus of brain cancer research today is to translate understanding of glioma biology into advances in treatment, by exploring the potential of target…”
Get full text

Chromosome 17 alterations identify good-risk and poor-risk tumors independently of clinical factors in medulloblastoma by McCabe, Martin G., Bäcklund, L. Magnus, Leong, Hui Sun, Ichimura, Koichi, Collins, V. Peter

“…Current risk stratification schemas for medulloblastoma, based on combinations of clinical variables and histotype, fail to accurately identify particularly…”
Get full text

Dual targeting of IGF-1R and PDGFR inhibits proliferation in high-grade gliomas cells and induces radiosensitivity in JNK-1 expressing cells by Carapancea, Mia, Cosaceanu, Daria, Budiu, Raluca, Kwiecinska, Anna, Tataranu, Ligia, Ciubotaru, Vasile, Alexandru, Oana, Banita, Monica, Pisoschi, Catalina, Bäcklund, Magnus L, Lewensohn, Rolf, Dricu, Anica

“…Increased expression and activation of receptor tyrosine kinases frequently occur in human brain tumors, mediating a variety of growth-promoting pathways and…”
Get full text

Parathyroid adenoma and primary CNS tumors by Bäcklund, L. Magnus, Grandér, Dan, Brandt, Lena, Hall, Per, Ekbom, Anders

“…Hyperparathyroidism onset at a young age is one feature in multiple endocrine neoplasia (MEN) type 1 and MEN type 2A cancer syndromes. There are several case…”
Get full text

High resolution array-based comparative genomic hybridisation of medulloblastomas and supra-tentorial primitive neuroectodermal tumours by McCabe, Martin Gerard, Ichimura, Koichi, Liu, Lu, Plant, Karen, Bäcklund, L Magnus, Pearson, Danita M, Collins, Vincent Peter

“…Medulloblastomas and supratentorial primitive neuroectodermal tumours are aggressive childhood tumours. We report our findings using array comparative genomic…”
Get full text