Search Results - "Bácskai, J."

Mitochondria and Calcium in Alzheimer’s Disease: From Cell Signaling to Neuronal Cell Death by Calvo-Rodriguez, Maria, Bacskai, Brian J.

“…Mitochondrial dysfunction has been implicated in the pathogenesis of almost all neurological diseases, including Alzheimer’s disease (AD). Historically, a…”
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Cerebral amyloid angiopathy and Alzheimer disease — one peptide, two pathways by Greenberg, Steven M., Bacskai, Brian J., Hernandez-Guillamon, Mar, Pruzin, Jeremy, Sperling, Reisa, van Veluw, Susanne J.

“…The shared role of amyloid-β (Aβ) deposition in cerebral amyloid angiopathy (CAA) and Alzheimer disease (AD) is arguably the clearest instance of crosstalk…”
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Emerging concepts in sporadic cerebral amyloid angiopathy by Charidimou, Andreas, Boulouis, Gregoire, Gurol, M Edip, Ayata, Cenk, Bacskai, Brian J, Frosch, Matthew P, Viswanathan, Anand, Greenberg, Steven M

“…Sporadic cerebral amyloid angiopathy is a common, well-defined small vessel disease and a largely untreatable cause of intracerebral haemorrhage and…”
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Vasomotion as a Driving Force for Paravascular Clearance in the Awake Mouse Brain by van Veluw, Susanne J., Hou, Steven S., Calvo-Rodriguez, Maria, Arbel-Ornath, Michal, Snyder, Austin C., Frosch, Matthew P., Greenberg, Steven M., Bacskai, Brian J.

“…Paravascular drainage of solutes, including β-amyloid (Aβ), appears to be an important process in brain health and diseases such as Alzheimer’s disease (AD)…”
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Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease by Calvo-Rodriguez, Maria, Hou, Steven S., Snyder, Austin C., Kharitonova, Elizabeth K., Russ, Alyssa N., Das, Sudeshna, Fan, Zhanyun, Muzikansky, Alona, Garcia-Alloza, Monica, Serrano-Pozo, Alberto, Hudry, Eloise, Bacskai, Brian J.

“…Mitochondria contribute to shape intraneuronal Ca 2+ signals. Excessive Ca 2+ taken up by mitochondria could lead to cell death. Amyloid beta (Aβ) causes…”
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Optogenetic Restoration of Disrupted Slow Oscillations Halts Amyloid Deposition and Restores Calcium Homeostasis in an Animal Model of Alzheimer's Disease by Kastanenka, Ksenia V, Hou, Steven S, Shakerdge, Naomi, Logan, Robert, Feng, Danielle, Wegmann, Susanne, Chopra, Vanita, Hawkes, Jonathan M, Chen, Xiqun, Bacskai, Brian J

“…Slow oscillations are important for consolidation of memory during sleep, and Alzheimer's disease (AD) patients experience memory disturbances. Thus, we…”
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Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice by Kuchibhotla, Kishore V, Lattarulo, Carli R, Hyman, Bradley T, Bacskai, Brian J

“…Although senile plaques focally disrupt neuronal health, the functional response of astrocytes to Alzheimer's disease pathology is unknown. Using multiphoton…”
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Mitochondrial alterations near amyloid plaques in an Alzheimer's disease mouse model by Xie, Hong, Guan, Jisong, Borrelli, Laura A, Xu, Jing, Serrano-Pozo, Alberto, Bacskai, Brian J

“…While accumulation of amyloid-β (Aβ) deposited as senile plaques is a hallmark feature of Alzheimer's disease (AD), the neurotoxicity of these deposits remains…”
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Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases by Bakker, Erik N. T. P., Bacskai, Brian J., Arbel-Ornath, Michal, Aldea, Roxana, Bedussi, Beatrice, Morris, Alan W. J., Weller, Roy O., Carare, Roxana O.

“…The lymphatic clearance pathways of the brain are different compared to the other organs of the body and have been the subject of heated debates. Drainage of…”
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Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model by Garcia‐Alloza, M., Borrelli, L. A., Rozkalne, A., Hyman, B. T., Bacskai, B. J.

“…Alzheimer’s disease (AD) is characterized by senile plaques and neurodegeneration although the neurotoxic mechanisms have not been completely elucidated. It is…”
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Rapid cell death is preceded by amyloid plaque-mediated oxidative stress by Xie, Hong, Hou, Steven, Jiang, Jun, Sekutowicz, Maria, Kelly, Jonathan, Bacskai, Brian J.

“…Neuronal loss is the ultimate outcome in a variety of neurodegenerative diseases and central nerve system disorders. Understanding the sequelae of events that…”
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Local Impermeant Anions Establish the Neuronal Chloride Concentration by Glykys, J., Dzhala, V., Egawa, K., Balena, T, Saponjian, Y., Kuchibhotla, K. V., Bacskai, B. J., Kahle, K. T., Zeuthen, T., Staley, K. J.

“…Neuronal intracellular chloride concentration [Cl–]i is an important determinant of γ-aminobutyric acid type A (GABAA) receptor (GABAAR)–mediated inhibition…”
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Slow Wave Sleep Is a Promising Intervention Target for Alzheimer's Disease by Lee, Yee Fun, Gerashchenko, Dmitry, Timofeev, Igor, Bacskai, Brian J, Kastanenka, Ksenia V

“…Alzheimer's disease (AD) is the major cause of dementia, characterized by the presence of amyloid-beta plaques and neurofibrillary tau tangles. Plaques and…”
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Blood-Brain Barrier Leakage and Microvascular Lesions in Cerebral Amyloid Angiopathy by Freeze, Whitney M, Bacskai, Brian J, Frosch, Matthew P, Jacobs, Heidi I.L, Backes, Walter H, Greenberg, Steven M, van Veluw, Susanne J

“…BACKGROUND AND PURPOSE—Cerebral amyloid angiopathy (CAA) is a common small vessel disease that independently effects cognition in older individuals. The…”
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Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer’s disease mouse models by Arbel-Ornath, Michal, Hudry, Eloise, Eikermann-Haerter, Katharina, Hou, Steven, Gregory, Julia L., Zhao, Lingzhi, Betensky, Rebecca A., Frosch, Matthew P., Greenberg, Steven M., Bacskai, Brian J.

“…The interstitial fluid (ISF) drainage pathway has been hypothesized to underlie the clearance of solutes and metabolites from the brain. Previous work has…”
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Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo by Kuchibhotla, Kishore V., Wegmann, Susanne, Kopeikina, Katherine J., Hawkes, Jonathan, Rudinskiy, Nikita, Andermann, Mark L., Spires-Jones, Tara L., Bacskai, Brian J., Hyman, Bradley T.

“…Alzheimer's disease (AD) is pathologically characterized by the deposition of extracellular amyloid-β plaques and intracellular aggregation of tau protein in…”
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Different microvascular alterations underlie microbleeds and microinfarcts by Veluw, Susanne J., Scherlek, Ashley A., Freeze, Whitney M., Telgte, Annemieke, Kouwe, Andre J., Bacskai, Brian J., Frosch, Matthew P., Greenberg, Steven M.

“…Objective Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of amyloid β (Aβ) in the walls of cortical vessels and the accrual of…”
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Ultrasound enhanced delivery of molecular imaging and therapeutic agents in Alzheimer's disease mouse models by Raymond, Scott B, Treat, Lisa H, Dewey, Jonathan D, McDannold, Nathan J, Hynynen, Kullervo, Bacskai, Brian J

“…Alzheimer's disease is a neurodegenerative disorder typified by the accumulation of a small protein, beta-amyloid, which aggregates and is the primary…”
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Polynuclear nickel hexacyanoferrates: monitoring of film growth and hydrated counter-cation flux/storage during redox reactions by Bácskai, J., Martinusz, K., Czirók, E., Inzelt, G., Kulesza, P.J., Malik, M.A.

“…An electrochemical quartz crystal microbalance (EQCM) was employed to monitor directly the growth of nickel(II) hexacyanoferrate(III) (NiHCNFe) films on gold…”
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Low frequency visual stimulation enhances slow wave activity without disrupting the sleep pattern in mice by Thankachan, Stephen, Yang, Chun, Kastanenka, Ksenia V., Bacskai, Brian J., Gerashchenko, Dmitry

“…Non-invasive stimulation technologies are emerging as potential treatment options for a range of neurodegenerative disorders. Experimental evidence suggests…”
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