Search Results - "BÜNEMANN, Moritz"

The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites by Hedderich, Janik B., Persechino, Margherita, Becker, Katharina, Heydenreich, Franziska M., Gutermuth, Torben, Bouvier, Michel, Bünemann, Moritz, Kolb, Peter

“…G-protein-coupled receptors do not only feature the orthosteric pockets, where most endogenous agonists bind, but also a multitude of other allosteric pockets…”
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Voltage regulates adrenergic receptor function by Rinne, Andreas, Birk, Alexandra, Bünemann, Moritz

“…The present study demonstrates that agonist-mediated activation of α2A adrenergic receptors (α ₂AAR) is voltage-dependent. By resolving the kinetics of…”
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DP2 receptor activity sensor suited for antagonist screening and measurement of receptor dynamics in real-time by Kurz, Michael, Ulrich, Michaela, Bittner, Alwina, Bünemann, Moritz

“…The DP2 receptor is a G-protein coupled receptor involved in allergic inflammation and is the target of recently developed antagonists already being tested in…”
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Opioid receptors: single molecule studies shed light on mechanisms of efficacy by Krasel, Cornelius, Bünemann, Moritz

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Comparative Docking to Distinct G Protein-Coupled Receptor Conformations Exclusively Yields Ligands with Agonist Efficacy by Scharf, Magdalena M, Bünemann, Moritz, Baker, Jillian G, Kolb, Peter

“…G protein-coupled receptors exist in a whole spectrum of conformations that are stabilized by the binding of ligands with different efficacy or intracellular…”
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The Effect of Cell Surface Expression and Linker Sequence on the Recruitment of Arrestin to the GIP Receptor by Al-Sabah, Suleiman, Adi, Lobna, Bünemann, Moritz, Krasel, Cornelius

“…The glucose-dependent insulinotropic polypeptide (GIP) and the glucagon-like peptide-1 (GLP-1) receptor are important targets in the treatment of both type 2…”
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Disentangling bias between Gq, GRK2, and arrestin3 recruitment to the M3 muscarinic acetylcholine receptor by Flöser, Anja, Becker, Katharina, Kostenis, Evi, König, Gabriele, Krasel, Cornelius, Kolb, Peter, Bünemann, Moritz

“…G protein-coupled receptors (GPCRs) transmit extracellular signals to the inside by activation of intracellular effector proteins. Different agonists can…”
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Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels by Dembla, Sandeep, Behrendt, Marc, Mohr, Florian, Goecke, Christian, Sondermann, Julia, Schneider, Franziska M, Schmidt, Marlene, Stab, Julia, Enzeroth, Raissa, Leitner, Michael G, Nuñez-Badinez, Paulina, Schwenk, Jochen, Nürnberg, Bernd, Cohen, Alejandro, Philipp, Stephan E, Greffrath, Wolfgang, Bünemann, Moritz, Oliver, Dominik, Zakharian, Eleonora, Schmidt, Manuela, Oberwinkler, Johannes

“…Opioids, agonists of µ-opioid receptors (µORs), are the strongest pain killers clinically available. Their action includes a strong central component, which…”
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Differential interaction patterns of opioid analgesics with µ opioid receptors correlate with ligand-specific voltage sensitivity by Kirchhofer, Sina B, Lim, Victor Jun Yu, Ernst, Sebastian, Karsai, Noemi, Ruland, Julia G, Canals, Meritxell, Kolb, Peter, Bünemann, Moritz

“…The µ opioid receptor (MOR) is the key target for analgesia, but the application of opioids is accompanied by several issues. There is a wide range of opioid…”
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Orphan G Protein–Coupled Receptor GPRC5B Controls Smooth Muscle Contractility and Differentiation by Inhibiting Prostacyclin Receptor Signaling by Carvalho, Jorge, Chennupati, Ramesh, Li, Rui, Günther, Stefan, Kaur, Harmandeep, Zhao, Wencai, Tonack, Sarah, Kurz, Michael, Mößlein, Nadja, Bünemann, Moritz, Offermanns, Stefan, Wettschureck, Nina

“…BACKGROUND:G protein–coupled receptors are important regulators of contractility and differentiation in vascular smooth muscle cells (SMCs), but the specific…”
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Structures in G proteins important for subtype selective receptor binding and subsequent activation by Jelinek, Volker, Mösslein, Nadja, Bünemann, Moritz

“…G protein-coupled receptors (GPCRs) selectively couple to specific heterotrimeric G proteins comprised of four subfamilies in order to induce appropriate…”
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Cyclic AMP Imaging in Adult Cardiac Myocytes Reveals Far-Reaching β1-Adrenergic but Locally Confined β2-Adrenergic Receptor–Mediated Signaling by Nikolaev, Viacheslav O, Bünemann, Moritz, Schmitteckert, Eva, Lohse, Martin J, Engelhardt, Stefan

“…β1- and β2-adrenergic receptors (βARs) are known to differentially regulate cardiomyocyte contraction and growth. We tested the hypothesis that these…”
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Gi Protein Activation in Intact Cells Involves Subunit Rearrangement Rather than Dissociation by Bünemann, Moritz, Frank, Monika, Lohse, Martin J.

“…G protein-coupled receptors transduce diverse extracellular signals, such as neurotransmitters, hormones, chemokines, and sensory stimuli, into intracellular…”
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Novel Single Chain cAMP Sensors for Receptor-induced Signal Propagation by Nikolaev, Viacheslav O., Bünemann, Moritz, Hein, Lutz, Hannawacker, Annette, Lohse, Martin J.

“…cAMP is a universal second messenger of many G-protein-coupled receptors and regulates a wide variety of cellular events. cAMP exerts its effects via…”
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Interaction kinetics between p115-RhoGEF and Gα13 are determined by unique molecular interactions affecting agonist sensitivity by Redlin, Fabian, Krett, Anna-Lena, Bünemann, Moritz

“…The three RH-RhoGEFs (Guanine nucleotide exchange factors) p115-RhoGEF, LARG (leukemia-associated RhoGEF) and PDZ-RhoGEF link G-protein coupled receptors…”
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Minireview: GPCR and G Proteins: Drug Efficacy and Activation in Live Cells by Vilardaga, Jean-Pierre, Bünemann, Moritz, Feinstein, Timothy N, Lambert, Nevin, Nikolaev, Viacheslav O, Engelhardt, Stefan, Lohse, Martin J, Hoffmann, Carsten

“…Many biochemical pathways are driven by G protein-coupled receptors, cell surface proteins that convert the binding of extracellular chemical, sensory, and…”
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Dynamics of receptor/G protein coupling in living cells by Hein, Peter, Frank, Monika, Hoffmann, Carsten, Lohse, Martin J, Bünemann, Moritz

“…The interaction of activated G protein‐coupled receptors with G proteins is a key event in signal transduction. Here, using a fluorescence resonance energy…”
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A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib by Sun, Tianliang, Yang, Lida, Kaur, Harmandeep, Pestel, Jenny, Looso, Mario, Nolte, Hendrik, Krasel, Cornelius, Heil, Daniel, Krishnan, Ramesh K, Santoni, Marie-Josée, Borg, Jean-Paul, Bünemann, Moritz, Offermanns, Stefan, Swiercz, Jakub M, Worzfeld, Thomas

“…Semaphorins comprise a large family of ligands that regulate key cellular functions through their receptors, plexins. In this study, we show that the…”
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Potentiation of receptor responses induced by prolonged binding of Gα13 and leukemia‐associated RhoGEF by Bodmann, Eva‐Lisa, Krett, Anna‐Lena, Bünemann, Moritz

“…ABSTRACT Diverse cellular functions are controlled by RhoA‐GTPases, which are activated by trimeric G proteins via RhoGEFs, among others. In this study, we…”
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The GIP receptor displays higher basal activity than the GLP-1 receptor but does not recruit GRK2 or arrestin3 effectively by Al-Sabah, Suleiman, Al-Fulaij, Munya, Shaaban, Ghina, Ahmed, Hanadi A, Mann, Rosalind J, Donnelly, Dan, Bünemann, Moritz, Krasel, Cornelius

“…Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are important regulators of insulin secretion, and their functional loss…”
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