Search Results - "Azzariti, Amalia"

Plasma-activated medium triggers cell death and the presentation of immune activating danger signals in melanoma and pancreatic cancer cells by Azzariti, Amalia, Iacobazzi, Rosa Maria, Di Fonte, Roberta, Porcelli, Letizia, Gristina, Roberto, Favia, Pietro, Fracassi, Francesco, Trizio, Ilaria, Silvestris, Nicola, Guida, Gabriella, Tommasi, Stefania, Sardella, Eloisa

“…Over the past decade, cold atmospheric plasmas have shown promising application in cancer therapy. The therapeutic use of plasma-activated media is a topic…”
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Circulating extracellular vesicles expressing PD1 and PD-L1 predict response and mediate resistance to checkpoint inhibitors immunotherapy in metastatic melanoma by Serratì, Simona, Guida, Michele, Di Fonte, Roberta, De Summa, Simona, Strippoli, Sabino, Iacobazzi, Rosa Maria, Quarta, Alessandra, De Risi, Ivana, Guida, Gabriella, Paradiso, Angelo, Porcelli, Letizia, Azzariti, Amalia

“…The immunotherapy with immune checkpoints inhibitors (ICI) has changed the life expectancy in metastatic melanoma (MM) patients. Nevertheless, several patients…”
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Hepatic stellate cells induce hepatocellular carcinoma cell resistance to sorafenib through the laminin‐332/α3 integrin axis recovery of focal adhesion kinase ubiquitination by Azzariti, Amalia, Mancarella, Serena, Porcelli, Letizia, Quatrale, Anna Elisa, Caligiuri, Alessandra, Lupo, Luigi, Dituri, Francesco, Giannelli, Gianluigi

“…In patients with hepatocellular carcinoma (HCC) receiving sorafenib, drug resistance is common. HCC develops in a microenvironment enriched with extracellular…”
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The β-adrenergic receptor antagonist propranolol offsets resistance mechanisms to chemotherapeutics in diverse sarcoma subtypes: a pilot study by Porcelli, Letizia, Garofoli, Marianna, Di Fonte, Roberta, Fucci, Livia, Volpicella, Mariateresa, Strippoli, Sabino, Guida, Michele, Azzariti, Amalia

“…Standard chemotherapy for soft tissue sarcomas has shown limited efficacy. Here, we sought to evaluate whether β-adrenergic receptor (β-AR) signalling…”
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Strategies to Improve Cancer Immune Checkpoint Inhibitors Efficacy, Other Than Abscopal Effect: A Systematic Review by Longo, Vito, Brunetti, Oronzo, Azzariti, Amalia, Galetta, Domenico, Nardulli, Patrizia, Leonetti, Francesco, Silvestris, Nicola

“…Despite that the impact of immune checkpoint inhibitors on malignancies treatment is unprecedented, a lack of response to these molecules is observed in…”
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Targeting human liver cancer cells with lactobionic acid-G(4)-PAMAM-FITC sorafenib loaded dendrimers by Iacobazzi, Rosa Maria, Porcelli, Letizia, Lopedota, Angela Assunta, Laquintana, Valentino, Lopalco, Antonio, Cutrignelli, Annalisa, Altamura, Emiliano, Di Fonte, Roberta, Azzariti, Amalia, Franco, Massimo, Denora, Nunzio

“…[Display omitted] Reported here is the synthesis and biological evaluation of the asialoglycoprotein receptor (ASGP-R) targeted fourth generation…”
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Gene Expression Comparison between the Lymph Node-Positive and -Negative Reveals a Peculiar Immune Microenvironment Signature and a Theranostic Role for WNT Targeting in Pancreatic Ductal Adenocarcinoma: A Pilot Study by Argentiero, Antonella, De Summa, Simona, Di Fonte, Roberta, Iacobazzi, Rosa Maria, Porcelli, Letizia, Da Vià, Matteo, Brunetti, Oronzo, Azzariti, Amalia, Silvestris, Nicola, Solimando, Antonio Giovanni

“…Over the past several years there has been much debate with regards to the prognostic and clinical significance of pancreatic ductal adenocarcinoma (PDAC) with…”
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Active notch protects MAPK activated melanoma cell lines from MEK inhibitor cobimetinib by Porcelli, Letizia, Mazzotta, Annalisa, Garofoli, Marianna, Di Fonte, Roberta, Guida, Gabriella, Guida, Michele, Tommasi, Stefania, Azzariti, Amalia

“…[Display omitted] •Notch boosts MAPK signaling in mutated uveal and cutaneous melanoma.•Notch inhibition counteracts GNAQ-induced MAPK activation.•Galunisertib…”
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Behind the Scene: Exploiting MC1R in Skin Cancer Risk and Prevention by Manganelli, Michele, Guida, Stefania, Ferretta, Anna, Pellacani, Giovanni, Porcelli, Letizia, Azzariti, Amalia, Guida, Gabriella

“…Melanoma and non-melanoma skin cancers (NMSCs) are the most frequent cancers of the skin in white populations. An increased risk in the development of skin…”
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Targeting Angiogenesis in Biliary Tract Cancers: An Open Option by Simone, Valeria, Brunetti, Oronzo, Lupo, Luigi, Testini, Mario, Maiorano, Eugenio, Simone, Michele, Longo, Vito, Rolfo, Christian, Peeters, Marc, Scarpa, Aldo, Azzariti, Amalia, Russo, Antonio, Ribatti, Domenico, Silvestris, Nicola

“…Biliary tract cancers (BTCs) are characterized by a bad prognosis and the armamentarium of drugs for their treatment is very poor. Although the inflammatory…”
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Tomatine Displays Antitumor Potential in In Vitro Models of Metastatic Melanoma by Serratì, Simona, Porcelli, Letizia, Guida, Stefania, Ferretta, Anna, Iacobazzi, Rosa Maria, Cocco, Tiziana, Maida, Immacolata, Tamasi, Gabriella, Rossi, Claudio, Manganelli, Michele, Tommasi, Stefania, Azzariti, Amalia, Guida, Gabriella

“…There is a growing interest in the cytotoxic effects of bioactive glycoalkaloids, such as α-tomatine on tumor cells. Here, for the first time, we determine the…”
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Circulating extracellular vesicles are monitoring biomarkers of anti-PD1 response and enhancer of tumor progression and immunosuppression in metastatic melanoma by Serratì, Simona, Di Fonte, Roberta, Porcelli, Letizia, De Summa, Simona, De Risi, Ivana, Fucci, Livia, Ruggieri, Eustachio, Marvulli, Tommaso Maria, Strippoli, Sabino, Fasano, Rossella, Rafaschieri, Tania, Guida, Gabriella, Guida, Michele, Azzariti, Amalia

“…Abstract Background Clinical drawback in checkpoint inhibitors immunotherapy (ICI) of metastatic melanoma (MM) is monitoring clinical benefit. Soluble forms of…”
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The ERRα–VDR axis promotes calcitriol degradation and estrogen signaling in breast cancer cells, while VDR‐CYP24A1‐ERRα overexpression correlates with poor prognosis in patients with basal‐like breast cancer by Danza, Katia, Porcelli, Letizia, De Summa, Simona, Di Fonte, Roberta, Pilato, Brunella, Lacalamita, Rosanna, Serratì, Simona, Azzariti, Amalia, Tommasi, Stefania

“…Vitamin D is used to reduce cancer risk and improve the outcome of cancer patients, but the vitamin D receptor (VDR; also known as the calcitriol receptor)…”
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Small-Cell Lung Cancer: Is Liquid Biopsy a New Tool Able to Predict the Efficacy of Immunotherapy? by Fasano, Rossella, Serratì, Simona, Rafaschieri, Tania, Longo, Vito, Di Fonte, Roberta, Porcelli, Letizia, Azzariti, Amalia

“…Small-cell lung cancer (SCLC) cases represent approximately 15% of all lung cancer cases, remaining a recalcitrant malignancy with poor survival and few…”
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New Oxaliplatin-Pyrophosphato Analogs with Improved In Vitro Cytotoxicity by Barbanente, Alessandra, Iacobazzi, Rosa Maria, Azzariti, Amalia, Hoeschele, James D, Denora, Nunzio, Papadia, Paride, Pacifico, Concetta, Natile, Giovanni, Margiotta, Nicola

“…Two new Pt(II)-pyrophosphato complexes containing the carrier ligands -1,3-diaminocyclohexane ( -1,3-DACH) and -1,2-diamine-4-cyclohexene (1,2-DACHEX),…”
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uPAR+ extracellular vesicles: a robust biomarker of resistance to checkpoint inhibitor immunotherapy in metastatic melanoma patients by Porcelli, Letizia, Guida, Michele, De Summa, Simona, Di Fonte, Roberta, De Risi, Ivana, Garofoli, Marianna, Caputo, Mariapia, Negri, Antonio, Strippoli, Sabino, Serratì, Simona, Azzariti, Amalia

“…BackgroundEmerging evidence has highlighted the importance of extracellular vesicle (EV)-based biomarkers of resistance to immunotherapy with checkpoint…”
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Dissecting the Potential Roles of Nigella sativa and Its Constituent Thymoquinone on the Prevention and on the Progression of Alzheimer's Disease by Cascella, Marco, Bimonte, Sabrina, Barbieri, Antonio, Del Vecchio, Vitale, Muzio, Maria Rosaria, Vitale, Andrea, Benincasa, Giulio, Ferriello, Anna Bella, Azzariti, Amalia, Arra, Claudio, Cuomo, Arturo

“…Several nutraceuticals have been investigated for preventing or retarding the progression of different neurodegenerative diseases, including Alzheimer's…”
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Gene Expression Comparison between Alcohol-Exposed versus Not Exposed Pancreatic Ductal Adenocarcinoma Patients Reveals a Peculiar TGFβ-Related Phenotype: An Exploratory Analysis by Doronzo, Antonio, Porcelli, Letizia, Marziliano, Donatello, Inglese, Gianfranco, Argentiero, Antonella, Azzariti, Amalia, Solimando, Antonio Giovanni

“…: Over the past few decades, there has been much debate and research into the link between alcohol consumption and the development and progression of…”
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Long Non-Coding RNA Landscape in Prostate Cancer Molecular Subtypes: A Feature Selection Approach by De Summa, Simona, Palazzo, Antonio, Caputo, Mariapia, Iacobazzi, Rosa Maria, Pilato, Brunella, Porcelli, Letizia, Tommasi, Stefania, Paradiso, Angelo Virgilio, Azzariti, Amalia

“…Prostate cancer is one of the most common malignancies in men. It is characterized by a high molecular genomic heterogeneity and, thus, molecular subtypes,…”
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Sigma-2 Receptor Agonists as Possible Antitumor Agents in Resistant Tumors: Hints for Collateral Sensitivity by Niso, Mauro, Abate, Carmen, Contino, Marialessandra, Ferorelli, Savina, Azzariti, Amalia, Perrone, Roberto, Colabufo, Nicola Antonio, Berardi, Francesco

“…With the aim of contributing to the development of novel antitumor agents, high‐affinity σ2 receptor agonists were developed, with…”
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