Relationship Between sCD163 and mCD163 and Their Implication in the Detection and Typing of Leprosy

Relationship Between sCD163 and mCD163 and Their Implication in the Detection and Typing of Leprosy

Leprosy is a chronic contagious disease caused by . CD163 is a monocyte trans-membrane glycoprotein receptor (mCD163) that sheds from the cell surface and circulates as a soluble (serum) form (sCD163). Changes in the mCD163 and sCD163 levels could mirror the categorization of inflammatory procedure,...

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Bibliographic Details
Published in:Clinical, cosmetic and investigational dermatology Vol. 13; pp. 379 - 389
Main Authors: Farag, Azza Gaber Antar, El Askary, Shymaa A, Fathy, Waleed M, Elbassal, Fathia, Azzam, Ayman Ali, Tayel, Nermin Reda, Abdul Karim, Samah Saad, Shehata, Wafaa Ahmed
Format: Journal Article
Language:English
Published: New Zealand Dove Medical Press Limited 01-01-2020
Taylor & Francis Ltd
Dove
Dove Medical Press
Subjects:
Analysis
Antibodies
Blood tests
cd163 positive monocytes
Communicable diseases
Cytokines
EDTA
Enzyme-linked immunosorbent assay
Enzymes
Flow cytometry
Hemoglobin
Inflammation
Leprosy
Medical equipment industry
Medical research
Original Research
Pathogenesis
scd163
Tropical diseases
United States
Egypt
United States > US
leprosy
flow cytometry
CD163 positive monocytes
sCD163
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Summary:Leprosy is a chronic contagious disease caused by . CD163 is a monocyte trans-membrane glycoprotein receptor (mCD163) that sheds from the cell surface and circulates as a soluble (serum) form (sCD163). Changes in the mCD163 and sCD163 levels could mirror the categorization of inflammatory procedure, demonstrating a possible use of CD163 as a diagnostic indicator of inflammation. To investigate the possible role of CD163 (sCD163 and mCD163) in leprosy pathogenesis and to assess whether CD163 is a helpful inflammatory marker of leprosy development and typing. This case control study included 70 leprosy patients and 30 healthy controls. Leprosy patients were classified according to the Madrid criteria (1953) into: tuberculoid leprosy (TT), border-line leprosy (BL), and lepromatous leprosy (LL). For all participants, complete blood count (CBC), serum CD163 using ELISA and monocytes positive for CD163 using flow cytometry were done. Leprosy patients had significantly low WBCs and platelet counts (p<0.001) and had significantly higher sCD163 (p=0.025) and mCD163 (p=0.042) that were highest in LL followed by BL, then TT patients (p<0.001). There was a significant positive correlation between mCD163 and sCD163 levels in leprosy patients (r=0.896, p<0.001). ROC analysis revealed a significant role of serum sCD163 and of mCD163 positive monocytes in the detection (p<0.001) and typing of leprosy (p=0.002 and p<0.001, respectively). Both sCD163 and mCD163 positive monocytes may have an active role in leprosy pathogenesis. They could be potential biomarkers for leprosy detection and typing.
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ISSN:1178-7015
1178-7015
DOI:10.2147/CCID.S240420