Search Results - "Azrolan, N."

ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes by Plump, A S, Azrolan, N, Odaka, H, Wu, L, Jiang, X, Tall, A, Eisenberg, S, Breslow, J L

“…The major high density lipoprotein (HDL) apolipoprotein, apoA-I, was knocked out by gene targeting in ES cells to provide a model for the study of HDL…”
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Dietary fat increases high density lipoprotein (HDL) levels both by increasing the transport rates and decreasing the fractional catabolic rates of HDL cholesterol ester and apolipoprotein (Apo) A-I : presentation of a new animal model and mechanistic studies in human Apo A-I transgenic and control mice by HAYEK, T, ITO, Y, AZROLAN, N, VERDERY, R. B, AALTO-SETÄLÄ, K, WALSH, A, BRESLOW, J. L

“…In humans, diets high in saturated fat and cholesterol raise HDL-cholesterol (HDL-C) levels. To explore the mechanism, we have devised a mouse model that…”
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Intestinal expression of the human apoA-I gene in transgenic mice is controlled by a DNA region 3' to the gene in the promoter of the adjacent convergently transcribed apoC-III gene by Walsh, A, Azrolan, N, Wang, K, Marcigliano, A, O'Connell, A, Breslow, J L

“…The apoA-I gene in humans is principally expressed in liver and small intestine. Using transgenic mice, we previously showed that 256 bp of 5' flanking DNA was…”
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Hypertriglyceridemia and cholesteryl ester transfer protein interact to dramatically alter high density lipoprotein levels, particle sizes, and metabolism : studies in transgenic mice by HAYEK, T, AZROLAN, N, VERDERY, R. B, WALSH, A, CHAJEK-SHAUL, T, AGELLON, L. B, TALL, A. R, BRESLOW, J. L

“…Several types of transgenic mice were used to study the influence of hypertriglyceridemia and cholesteryl ester transfer protein (CETP) expression on high…”
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Plasma Lp(a) concentration is inversely correlated with the ratio of Kringle IV/Kringle V encoding domains in the Apo(a) gene by GAVISH, D, AZROLAN, N, BRESLOW, J. L

“…Plasma Lp(a) levels correlate with atherosclerosis susceptibility. This lipoprotein consists of an LDL-like particle attached to a large glycoprotein called…”
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Plasma lipoprotein(a) concentration is controlled by apolipoprotein(a) (apo(a)) protein size and the abundance of hepatic apo(a) mRNA in a cynomolgus monkey model by AZROLAN, N, GAVISH, D, BRESLOW, J. L

“…The cynomolgus macaque was used as a model to study lipoprotein(a) (Lp(a)). Antibodies to Lp(a) were used in Ouchterlony and Western blot analysis to show that…”
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Dietary Fat Elevates Hepatic ApoA-I Production by Increasing the Fraction of Apolipoprotein A-I mRNA in the Translating Pool (∗) by Azrolan, Neal, Odaka, Hiroyuki, Breslow, Jan L., Fisher, Edward A.

“…Elevated plasma high density lipoprotein cholesterol (HDL-C) levels are associated with a decreased risk for coronary heart disease. Ironically, diets enriched…”
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A discoordinate increase in the cellular amount of 3-hydroxy-3-methylglutaryl-CoA reductase results in the loss of rate-limiting control over cholesterogenesis in a tumour cell-free system by Azrolan, N I, Coleman, P S

“…Cholesterol biosynthesis was characterized in cell-free post-mitochondrial supernatant systems prepared from both normal rat liver and Morris hepatoma 3924A…”
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Human Placental Tissue Expresses a Novel 22.7 kDa Apolipoprotein A-I-like Protein by Richardson, B, Palgunachari, M. N, Anantharamaiah, G. M, Richards, R. G, Azrolan, N, Wiginton, D, Handwerger, S

“…Since apolipoprotein A-I (apo A-I) and HDL stimulate the expression of the placental hormone human placental lactogen (hPL), experiments were performed to…”
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Atazanavir Modestly Increases Plasma Levels of Raltegravir in Healthy Subjects by Iwamoto, Marian, Wenning, Larissa A., Mistry, Goutam C., Petry, Amelia S., Liou, Sarah Y., Ghosh, Kaylan, Breidinger, Sheila, Azrolan, Neal, Gutierrez, Maria J., Bridson, William E., Stone, Julie A., Gottesdiener, Keith M., Wagner, John A.

“…Raltegravir is an HIV integrase inhibitor that is metabolized through glucuronidation by uridine diphosphate glucuronosyltransferase 1A1, and its use is…”
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Effects of Omeprazole on Plasma Levels of Raltegravir by Iwamoto, Marian, Wenning, Larissa A., Nguyen, Bach-Yen, Teppler, Hedy, Moreau, Allison R., Rhodes, Rand R., Hanley, William D., Jin, Bo, Harvey, Charlotte M., Breidinger, Sheila A., Azrolan, Neal, Farmer, H. Frank, Isaacs, Robin D., Chodakewitz, Jeffery A., Stone, Julie A., Wagner, John A.

“…Raltegravir, a human immunodeficiency virus type 1 (HIV-1) integrase inhibitor, has pH-dependent solubility. Raltegravir plasma concentration increases with…”
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A solution hybridization/RNase protection assay with riboprobes to determine absolute levels of apoB, A-I, and E mRNA in human hepatoma cell lines by Azrolan, N, Breslow, JL

“…A solution hybridization/RNase protection assay with riboprobes was developed to quantitate apolipoprotein mRNA concentrations. Previously, radiolabeled DNA…”
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Protective Effect of the Immunosuppressant Sirolimus Against Aortic Atherosclerosis In Apo E‐Deficient Mice by Elloso, M. Merle, Azrolan, Neal, Sehgal, Suren N., Hsu, Pa‐Lang, Phiel, Kristen L., Kopec, Caroline A., Basso, Michael D., Adelman, Steven J.

“…Atherosclerosis is a chronic inflammatory disease that develops in response to injury to the vessel wall, and is augmented by hypercholesterolemia. To further…”
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A Double-Blind, Randomized, Controlled, Multicenter Safety and Immunogenicity Study of a Refrigerator-Stable Formulation of Zostavax by Gilderman, Larry I, Lawless, James F, Nolen, Thomas M, Sterling, Tina, Rutledge, Ruth Z, Fernsler, Doreen A, Azrolan, Neal, Sutradhar, Santosh C, Wang, William W, Chan, Ivan S F, Schlienger, Katia, Schödel, Florian, Silber, Jeffrey L

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Hypertriglyceridemia as a Result of Human Apo CIII Gene Expression in Transgenic Mice by Ito, Yasushi, Azrolan, Neal, O'Connell, Anita, Walsh, Annemarie, Breslow, Jan L.

“…Primary and secondary hypertriglyceridemia is common in the general population, but the biochemical basis for this disease is largely unknown. With the use of…”
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Idea management: restructuring technology-based research to help achieve corporate goals by Azrolan, N, Pavlin, M S

“…In order for some technology-based companies to continue to compete, they must consider changes and improvements in the mechanism(s) by which new ideas are…”
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Antigenic differences between Anabaena azollae fresh from the Azolla fern leaf cavity and free-living cyanobacteria by Gates, J. E., Fisher, R. W., Goggin, T. W., Azrolan, N. I.

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The full induction of human apoprotein A-I gene expression by the experimental nephrotic syndrome in transgenic mice depends on cis-acting elements in the proximal 256 base-pair promoter region and the trans-acting factor early growth response factor 1 by Zaiou, M, Azrolan, N, Hayek, T, Wang, H, Wu, L, Haghpassand, M, Cizman, B, Madaio, M P, Milbrandt, J, Marsh, J B, Breslow, J L, Fisher, E A

“…To identify molecular factors regulating apo A-I production in vivo, we induced in transgenic mice the experimental nephrotic syndrome, which results in…”
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1.P.25 Induction of human apoprotein A-I gene expression in transgenic mice with nephrotic syndrome by Zaiou, M., Azrolan, N., Hayek, T., Wang, H., Cizman, B., Madaio, M.M., Marsh, J.B., Breslow, J.L., Fisher, E.A.

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Plasma Ip(a) concentration is inversely correlated with the ratio of Kringle IV/Kringle V encoding domains in the apo(a) gene by Gavish, D, Azrolan, N, Breslow, J L

“…Plasma Lp(a) levels correlate with atherosclerosis susceptibility. This lipoprotein consists of an LDL-like particle attached to a large glycoprotein called…”
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