Search Results - "Azouz, Nurit P"

Achieving Precision Medicine in Allergic Disease: Progress and Challenges by Proper, Steven P, Azouz, Nurit P, Mersha, Tesfaye B

“…Allergic diseases (atopic dermatitis, food allergy, eosinophilic esophagitis, asthma and allergic rhinitis), perhaps more than many other traditionally grouped…”
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Broad transcriptional response of the human esophageal epithelium to proton pump inhibitors by Rochman, Mark, Xie, Yong Mei, Mack, Lydia, Caldwell, Julie M., Klingler, Andrea M., Osswald, Garrett A., Azouz, Nurit P., Rothenberg, Marc E.

“…Proton pump inhibitors (PPIs) have been recognized as a primary treatment of eosinophilic esophagitis (EoE), an allergic inflammatory disease of the esophageal…”
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Functional role of kallikrein 5 and proteinase-activated receptor 2 in eosinophilic esophagitis by Azouz, Nurit P, Klingler, Andrea M, Pathre, Purnima, Besse, John A, Baruch-Morgenstern, Netali Ben, Ballaban, Adina Y, Osswald, Garrett A, Brusilovsky, Michael, Habel, Jeff E, Caldwell, Julie M, Ynga-Durand, Mario A, Abonia, Pablo J, Hu, Yueh-Chiang, Wen, Ting, Rothenberg, Marc E

“…Eosinophilic esophagitis (EoE) is a chronic, food antigen-driven, inflammatory disease of the esophagus and is associated with impaired barrier function…”
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Profound loss of esophageal tissue differentiation in patients with eosinophilic esophagitis by Rochman, Mark, PhD, Travers, Jared, BS, Miracle, Cora E, Bedard, Mary C., BS, Wen, Ting, PhD, Azouz, Nurit P., PhD, Caldwell, Julie M., PhD, KC, Kiran, BS, Sherrill, Joseph D., PhD, Davis, Benjamin P., MD, PhD, Rymer, Jeffrey K., BS, Kaufman, Kenneth M., PhD, Aronow, Bruce J., PhD, Rothenberg, Marc E., MD, PhD

“…Background A key question in the allergy field is to understand how tissue-specific disease is manifested. Eosinophilic esophagitis (EoE) is an emerging…”
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Decoding the regulation of mast cell exocytosis by networks of Rab GTPases by Azouz, Nurit P, Matsui, Takahide, Fukuda, Mitsunori, Sagi-Eisenberg, Ronit

“…Exocytosis is a key event in mast cell functions. By this process, mast cells release inflammatory mediators, contained in secretory granules (SGs), which play…”
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Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2-Priming Protease TMPRSS2 by Azouz, Nurit P, Klingler, Andrea M, Callahan, Victoria, Akhrymuk, Ivan V, Elez, Katarina, Raich, Lluís, Henry, Brandon M, Benoit, Justin L, Benoit, Stefanie W, Noé, Frank, Kehn-Hall, Kylene, Rothenberg, Marc E

“…Host proteases have been suggested to be crucial for dissemination of MERS, SARS-CoV, and SARS-CoV-2 coronaviruses, but the relative contribution of membrane…”
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Rab5 is a novel regulator of mast cell secretory granules: impact on size, cargo, and exocytosis by Azouz, Nurit P, Zur, Neta, Efergan, Adi, Ohbayashi, Norihiko, Fukuda, Mitsunori, Amihai, Dina, Hammel, Ilan, Rothenberg, Marc E, Sagi-Eisenberg, Ronit

“…Secretion of inflammatory mediators prestored in mast cells secretory granules (SGs) enhances immune responses such as in allergy and host defense. However,…”
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Rab5 is critical for SNAP23 regulated granule-granule fusion during compound exocytosis by Klein, Ofir, Roded, Amit, Zur, Neta, Azouz, Nurit P., Pasternak, Olga, Hirschberg, Koret, Hammel, Ilan, Roche, Paul A., Yatsu, Ayaka, Fukuda, Mitsunori, Galli, Stephen J., Sagi-Eisenberg, Ronit

“…Compound exocytosis is considered the most massive mode of exocytosis, during which the membranes of secretory granules (SGs) fuse with each other to form a…”
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Aryl hydrocarbon receptor and IL-13 signaling crosstalk in human keratinocytes and atopic dermatitis by Proper, Steven P, Dwyer, Alexander T, Appiagyei, Andrews, Felton, Jennifer M, Ben-Baruch Morgenstern, Netali, Marlman, Justin M, Kotliar, Michael, Barski, Artem, Troutman, Ty D, Rothenberg, Marc E, Mersha, Tesfaye B, Azouz, Nurit P

“…Atopic dermatitis (AD) is an allergic skin disease mediated by skin barrier impairment and IL-13-driven immune response. Activation of the aryl hydrocarbon…”
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Epithelial origin of eosinophilic esophagitis by Rochman, Mark, Azouz, Nurit P., Rothenberg, Marc E.

“…Eosinophilic esophagitis (EoE) is a chronic, allergen-driven inflammatory disease of the esophagus characterized predominantly by eosinophilic inflammation,…”
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Molecular mechanism of inhibiting the SARS-CoV-2 cell entry facilitator TMPRSS2 with camostat and nafamostat by Hempel, Tim, Raich, Lluís, Olsson, Simon, Azouz, Nurit P, Klingler, Andrea M, Hoffmann, Markus, Pöhlmann, Stefan, Rothenberg, Marc E, Noé, Frank

“…The entry of the coronavirus SARS-CoV-2 into human lung cells can be inhibited by the approved drugs camostat and nafamostat. Here we elucidate the molecular…”
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Mechanisms of gastrointestinal allergic disorders by Azouz, Nurit P, Rothenberg, Marc E

“…Gastrointestinal (GI) allergic disease is an umbrella term used to describe a variety of adverse, food antigen-driven, immune-mediated diseases. Although these…”
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A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells by Mahoney, Matthew, Damalanka, Vishnu C., Tartell, Michael A., Chung, Dong hee, Lourenço, André Luiz, Pwee, Dustin, Bridwell, Anne E. Mayer, Hoffmann, Markus, Voss, Jorine, Karmakar, Partha, Azouz, Nurit P., Klingler, Andrea M., Rothlauf, Paul W., Thompson, Cassandra E., Lee, Melody, Klampfer, Lidija, Stallings, Christina L., Rothenberg, Marc E., Pöhlmann, Stefan, Whelan, Sean P. J., O’Donoghue, Anthony J., Craik, Charles S., Janetka, James W.

“…The host cell serine protease TMPRSS2 is an attractive therapeutic target for COVID-19 drug discovery. This protease activates the Spike protein of severe…”
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Measurement of Exocytosis in Genetically Manipulated Mast Cells by Klein, Ofir, Azouz, Nurit P, Sagi-Eisenberg, Ronit

“…The hallmark of mast cell activation is secretion of immune mediators by regulated exocytosis. Measurements of mediator secretion from mast cells that are…”
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Uncovering the secretes of allergic inflammation by Brusilovsky, Michael, Rochman, Mark, Azouz, Nurit P, Mack, Lydia E, Rothenberg, Marc E

“…Allergic asthma is a chronic inflammatory lung disease associated with increased cytokine secretion. Aspects of airway inflammation are also linked to a common…”
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Rab12 Regulates Retrograde Transport of Mast Cell Secretory Granules by Interacting with the RILP-Dynein Complex by Efergan, Adi, Azouz, Nurit P, Klein, Ofir, Noguchi, Kenta, Rothenberg, Marc E, Fukuda, Mitsunori, Sagi-Eisenberg, Ronit

“…Secretory granule (SG) transport is a critical step in regulated exocytosis including degranulation of activated mast cells. The latter process results in the…”
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The antiprotease SPINK7 serves as an inhibitory checkpoint for esophageal epithelial inflammatory responses by Azouz, Nurit P, Ynga-Durand, Mario A, Caldwell, Julie M, Jain, Ayushi, Rochman, Mark, Fischesser, Demetria M, Ray, Leanne M, Bedard, Mary C, Mingler, Melissa K, Forney, Carmy, Eilerman, Matthew, Kuhl, Jonathan T, He, Hua, Biagini Myers, Jocelyn M, Mukkada, Vincent A, Putnam, Philip E, Khurana Hershey, Gurjit K, Kottyan, Leah C, Wen, Ting, Martin, Lisa J, Rothenberg, Marc E

“…Loss of barrier integrity has an important role in eliciting type 2 immune responses, yet the molecular events that initiate and connect this with allergic…”
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Deletion of SPINK7 by CRISPR/Cas9 Elicits Pro-Inflammatory and Impaired Epithelial Barrier Responses in Esophageal Epithelial Cells by Jain, Ayushi, Azouz, Nurit P., Caldwell, Julie M., Rothenberg, Marc E.

“…SPINK7 protein expression was assessed by western-blot, barrier integrity by trans-epithelial electrical resistance, and filaggrin mRNA expression by qPCR…”
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A key role for IL-13 signaling via the type 2 IL-4 receptor in experimental atopic dermatitis by Bitton, Almog, Avlas, Shmuel, Reichman, Hadar, Itan, Michal, Karo-Atar, Danielle, Azouz, Nurit P, Rozenberg, Perri, Diesendruck, Yael, Nahary, Limor, Rothenberg, Marc E, Benhar, Itai, Munitz, Ariel

“…IL-13 and IL-4 are potent mediators of type 2-associated inflammation such as those found in atopic dermatitis (AD). IL-4 shares overlapping biological…”
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The Anti-protease SPINK7 is a Checkpoint Regulator of Esophageal Epithelial Inflammatory Responses by Azouz, Nurit P., Ynga-Durand, Mario Alberto, Caldwell, Julie M., Jain, Ayushi, Bedard, Mary, Rochman, Mark, Michael, Demetria, Mingler, Melissa K., Forney, Carmy, Wen, Ting, Kuhl, Jonathan, He, Hua, Biagini Myers, Jocelyn M., Mukkada, Vincent A., Putnam, Philip E., Khurana Hershey, Gurjit K., Kottyan, Leah C., Martin, Lisa J., Rothenberg, Marc E.

“…Protease activity of SPINK7 deficient epithelial cells and human esophageal tissue was measured, and receptor expression of esophageal tissue-derived…”
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