Search Results - "Azouz, Amany A."

Impact of the ACE2 activator xanthenone on tacrolimus nephrotoxicity: Modulation of uric acid/ERK/p38 MAPK and Nrf2/SOD3/GCLC signaling pathways by Azouz, Amany A., Omar, Hany A., Hersi, Fatema, Ali, Fares E.M., Hussein Elkelawy, Asmaa Mohammed M.

“…The calcineurin inhibitor tacrolimus is an effective and widely used immunosuppressant after organ transplantation to reduce graft rejection. However, its…”
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Design, synthesis, analgesic, anti-inflammatory activity of novel pyrazolones possessing aminosulfonyl pharmacophore as inhibitors of COX-2/5-LOX enzymes: Histopathological and docking studies by Abdelgawad, Mohamed A., Labib, Madlen B., Ali, Waleed A.M., Kamel, Gehan, Azouz, Amany A., EL-Nahass, EL-Shaymaa

“…[Display omitted] •Compounds 5d, 5f and 5i were found to be the most potent COX-2/5-LOX inhibitors with superior COX-2 selectivity index.•Four compounds; 5b,…”
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Novel tetrazole and cyanamide derivatives as inhibitors of cyclooxygenase-2 enzyme: design, synthesis, anti-inflammatory evaluation, ulcerogenic liability and docking study by Lamie, Phoebe F., Philoppes, John N., Azouz, Amany A., Safwat, Nesreen M.

“…Nineteen new compounds containing tetrazole and/or cyanamide moiety have been designed and synthesised. Their structures were confirmed using spectroscopic…”
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Aliskiren, tadalafil, and cinnamaldehyde alleviate joint destruction biomarkers; MMP-3 and RANKL; in complete Freund's adjuvant arthritis model: Downregulation of IL-6/JAK2/STAT3 signaling pathway by Azouz, Amany A., Saleh, Esraa, Abo-Saif, Ali A.

“…Rheumatoid arthritis (RA) is an autoimmune inflammatory disease, which is accompanied by progressive joint damage and disability. The intolerability of…”
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Amlodipine alleviates cisplatin-induced nephrotoxicity in rats through gamma-glutamyl transpeptidase (GGT) enzyme inhibition, associated with regulation of Nrf2/HO-1, MAPK/NF-κB, and Bax/Bcl-2 signaling by Azouz, Amany A., Abdel-Nassir Abdel-Razek, Esraa, Abo-Youssef, Amira M.

“…[Display omitted] The therapeutic utility of the effective chemotherapeutic agent cisplatin is hampered by its nephrotoxic effect. We aimed from the current…”
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Interference with megalin expression/endocytic function by montelukast mitigates gentamicin nephrotoxicity: Downregulation of ClC-5 expression by Azouz, Amany A., Hanna, Dina A., Abo-Saif, Ali A., Anwar Shehata Messiha, Basim

“…[Display omitted] •GM administration upregulated megalin and ClC-5 protein expressions.•Concurrent treatment with MLK downregulated ClC-5 protein…”
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The impact of omeprazole on mycophenolate pharmacokinetics in kidney transplant recipients by AbdElhalim, Mohamed S, Kenawy, Ahmed S, Demellawy, Heba H El, Azouz, Amany A, Alghanem, Sarah S, Al-Otaibi, Torki, Gheith, Osama, ElMonem, Mohamed Abd, Afifi, Mohammed K, Hussein, Raghda R S

“…The absorption rates of mycophenolate mofetil (MMF) and enteric-coated mycophenolate sodium (EC-MPS) may be influenced by the concomitant use of omeprazole…”
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Optimization of osteoporosis and osteopenia management among renal transplant recipients by Afifi, Mohammed K., Kenawy, Ahmed S., El Demellawy, Heba H., Azouz, Amany A., Al-Otaibi, Torki, Gheith, Osama, ElMonem, Mohamed Abd, AbdElhalim, Mohamed S., Hussein, Raghda R. S.

“…Background Osteoporosis and osteopenia occur frequently in renal transplant recipients due to long-term use of immune-suppressants including corticosteroids…”
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Modulation of SIRT6 related signaling pathways of p-AKT/mTOR and NRF2/HO-1 by memantine contributes to curbing the progression of tamoxifen/HFD-induced MASH in rats by Ezz-Eldin, Yousra M., El-Din Ewees, Mohamed Gamal, Khalaf, Marwa M., Azouz, Amany A.

“…Metabolic dysfunction-associated steatohepatitis (MASH) is a chronic liver disorder marked by hepatic fat accumulation and inflammatory infiltrates which may…”
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Novel pyrimidine-pyridine hybrids: Synthesis, cyclooxygenase inhibition, anti-inflammatory activity and ulcerogenic liability by Abdelgawad, Mohamed A., Bakr, Rania B., Azouz, Amany A.

“…[Display omitted] •Compound 11c was the most active with edema inhibitory percent = 74% after 1 h.•The target compounds were detected to be selective…”
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Enhanced eNOS/nitric oxide production by nebivolol interferes with TGF-β1/Smad3 signaling and collagen I deposition in the kidney after prolonged tacrolimus administration by Azouz, Amany A., Tohamy, Mohamed A., Ali, Fares E.M., Mahmoud, Heba M.

“…Tacrolimus is an effective immunosuppressant commonly used post-transplantation and in certain autoimmune diseases. However, its long-term administration is…”
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Hepatoprotective effects of diosmin and/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1/Nrf-2 and P 38 -MAPK/NF-κB/iNOS signaling pathway by Ali, Fares E M, Azouz, Amany A, Bakr, Adel G, Abo-Youssef, Amira M, Hemeida, Ramadan A M

“…The present study was designed to investigate the potential protective effects of diosmin (DS) and/or sildenafil against bile duct ligation (BDL). In order to…”
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Investigating the tamoxifen/high-fat diet synergy: a promising paradigm for nonalcoholic steatohepatitis induction in a rat model by Ezz-Eldin, Yousra M., Ewees, Mohamed G., Azouz, Amany A., Khalaf, Marwa M.

“…Non-alcoholic steatohepatitis (NASH) is a severe liver condition characterized by excessive fat deposition, ballooning, and lobular inflammation. This…”
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Benzbromarone mitigates cisplatin nephrotoxicity involving enhanced peroxisome proliferator-activated receptor-alpha (PPAR-α) expression by Abdel-Razek, Esraa Abdel-Nassir, Abo-Youssef, Amira M., Azouz, Amany A.

“…Despite the great efficacy reported for cisplatin as a widely used chemotherapeutic agent, its clinical use is limited by the challenge of facing its serious…”
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Hepatoprotective effects of diosmin and/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1/Nrf-2 and P38-MAPK/NF-κB/iNOS signaling pathway by Ali, Fares E.M., Azouz, Amany A., Bakr, Adel G., Abo-youssef, Amira M., Hemeida, Ramadan A.M.

“…The present study was designed to investigate the potential protective effects of diosmin (DS) and/or sildenafil against bile duct ligation (BDL). In order to…”
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Selective cyclooxygenase inhibition and ulcerogenic liability of some newly prepared anti-inflammatory agents having thiazolo[4,5-d]pyrimidine scaffold by Bakr, Rania B., Ghoneim, Amira A., Azouz, Amany A.

“…New thiazolo[4,5-d]pyrimidines (9a-l) were prepared and screened for their cyclooxygenase inhibitory effect, anti-inflammatory activity and ulcerogenic…”
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The modulatory effects of cinnamaldehyde on uric acid level and IL-6/JAK1/STAT3 signaling as a promising therapeutic strategy against benign prostatic hyperplasia by Afify, Hassan, Abo-Youssef, Amira M., Abdel-Rahman, Hanaa M., Allam, Shady, Azouz, Amany A.

“…Benign prostatic hyperplasia (BPH) is a widespread disorder in elderly men. Cinnamaldehyde, which is a major constituent in the essential oil of cinnamon, has…”
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Regulation of renal nitric oxide and eNOS/iNOS expression by tadalafil participates in the mitigation of amphotericin B–induced renal injury: Down-regulation of NF-κB/iNOS/caspase-3 signaling by Abdel-Rahman, Doaa M., Messiha, Basim Anwar Shehata, Ali, Fares E.M., Azouz, Amany A.

“…Amphotericin B (AmB)–induced acute kidney injury (AKI) is a common health problem having an undesirable impact on its urgent therapeutic utility for fatal…”
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Balancing renal Ang-II/Ang-(1-7) by xanthenone; an ACE2 activator; contributes to the attenuation of Ang-II/p38 MAPK/NF-κB p65 and Bax/caspase-3 pathways in amphotericin B-induced nephrotoxicity in rats by Azouz, Amany A., Abdel-Rahman, Doaa M., Messiha, Basim Anwar Shehata

“…Despite the great importance of amphotericin B for the management of life-threatening systemic fungal infections, its nephrotoxic effect restricts its repeated…”
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Targeting Keap-1/Nrf-2 pathway and cytoglobin as a potential protective mechanism of diosmin and pentoxifylline against cholestatic liver cirrhosis by Ali, Fares E.M., Bakr, Adel G., Abo-youssef, Amira M., Azouz, Amany A., Hemeida, Ramadan A.M.

“…The effects of diosmin (DS), pentoxifylline (PTX) and their combination on inflammatory response, oxidant/antioxidant balance, cytoglobin and cirrhotic…”
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