Search Results - "Aznar, J. M."

From individual to collective 3D cancer dissemination: roles of collagen concentration and TGF-β by Plou, J., Juste-Lanas, Y., Olivares, V., del Amo, C., Borau, C., García-Aznar, J. M.

“…Cancer cells have the ability to migrate from the primary (original) site to other places in the body. The extracellular matrix affects cancer cell migratory…”
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Degradation of extracellular matrix regulates osteoblast migration: A microfluidic-based study by Movilla, N., Borau, C., Valero, C., García-Aznar, J.M.

“…Bone regeneration is strongly dependent on the capacity of cells to move in a 3D microenvironment, where a large cascade of signals is activated. To improve…”
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Fibroblast Migration in 3D is Controlled by Haptotaxis in a Non-muscle Myosin II-Dependent Manner by Moreno-Arotzena, O., Borau, C., Movilla, N., Vicente-Manzanares, M., García-Aznar, J. M.

“…Cell migration in 3D is a key process in many physiological and pathological processes. Although valuable knowledge has been accumulated through analysis of…”
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Exploring the potential of Physics-Informed Neural Networks to extract vascularization data from DCE-MRI in the presence of diffusion by Sainz-DeMena, D., Pérez, M.A., García-Aznar, J.M.

“…Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is widely used to assess tissue vascularization, particularly in oncological applications…”
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On scaffold designing for bone regeneration: A computational multiscale approach by SANZHERRERA, J, GARCIAAZNAR, J, DOBLARE, M

“…Scaffold design for bone tissue engineering applications involves many parameters that directly influence the rate of bone tissue regeneration onto its…”
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Quantifying 3D chemotaxis in microfluidic-based chips with step gradients of collagen hydrogel concentrations by Del Amo, C, Borau, C, Movilla, N, Asín, Jesús, García-Aznar, J M

“…Cell migration is an essential process involved in crucial stages of tissue formation, regeneration or immune function as well as in pathological processes…”
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An iterative finite element-based method for solving inverse problems in traction force microscopy by Cóndor, M., García-Aznar, J.M.

“…•Formulation of a new 3-D traction force microscopy inverse method by using a recursive algorithm based on finite elements.•Explore cellular forces in…”
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Challenges in the Modeling of Wound Healing Mechanisms in Soft Biological Tissues by Valero, C., Javierre, E., García-Aznar, J. M., Menzel, A., Gómez-Benito, M. J.

“…Numerical models have become one of the most powerful tools in biomechanics and mechanobiology allowing highly detailed simulations. One of the fields in which…”
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A multiscale orchestrated computational framework to reveal emergent phenomena in neuroblastoma by Borau, C., Wertheim, K.Y., Hervas-Raluy, S., Sainz-DeMena, D., Walker, D., Chisholm, R., Richmond, P., Varella, V., Viceconti, M., Montero, A., Gregori-Puigjané, E., Mestres, J., Kasztelnik, M., García-Aznar, J.M.

“…•Multi-scale neuroblastoma model for patient-specific simulations.•Model spans 9 orders of magnitude in space and time.•Cloud-based platform closes gap between…”
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A phenomenological approach to modelling collective cell movement in 2D by Rey, R., García-Aznar, J. M.

“…There are two main approaches to unraveling the mechanisms involved in the regulation of collective cell movement. On the one hand, “in vitro” tests try to…”
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Finite element simulation for the mechanical characterization of soft biological materials by atomic force microscopy by Valero, C., Navarro, B., Navajas, D., García-Aznar, J.M.

“…The characterization of the mechanical properties of soft materials has been traditionally performed through uniaxial tensile tests. Nevertheless, this method…”
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A phenomenological cohesive model for the macroscopic simulation of cell–matrix adhesions by Cóndor, M., García-Aznar, J. M.

“…Cell adhesion is crucial for cells to not only physically interact with each other but also sense their microenvironment and respond accordingly. In fact,…”
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Mechanotherapy as an alternative for cancer treatment by Garcia-Aznar, JM

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Scaffold microarchitecture determines internal bone directional growth structure: A numerical study by SANZ-HERRERA, J. A, DOBLARE, M, GARCIA-AZNAR, J. M

“…Abstract A number of successful results have been reported in bone tissue engineering, although the routine clinical practice has not been reached so far. One…”
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Computational model of mesenchymal migration in 3D under chemotaxis by Ribeiro, F. O., Gómez-Benito, M. J., Folgado, J., Fernandes, P. R., García-Aznar, J. M.

“…Cell chemotaxis is an important characteristic of cellular migration, which takes part in crucial aspects of life and development. In this work, we propose a…”
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Computational evaluation of different numerical tools for the prediction of proximal femur loads from bone morphology by Garijo, N., Martínez, J., García-Aznar, J.M., Pérez, M.A.

“…•We ideally estimate patient-specific loads from bone geometry and density measurement.•We combine FE, bone remodeling models, and machine learning…”
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Modeling of anisotropic wound healing by Valero, C., Javierre, E., García-Aznar, J.M., Gómez-Benito, M.J., Menzel, A.

“…Biological soft tissues exhibit non-linear complex properties, the quantification of which presents a challenge. Nevertheless, these properties, such as skin…”
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Influence of fracture gap size on the pattern of long bone healing: a computational study by Gómez-Benito, M.J., García-Aznar, J.M., Kuiper, J.H., Doblaré, M.

“…Following fractures, bones restore their original structural integrity through a complex process in which several cellular events are involved. Among other…”
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Subject-specific musculoskeletal loading of the tibia: Computational load estimation by Garijo, N., Verdonschot, N., Engelborghs, K., García-Aznar, J.M., Pérez, M.A.

“…The systematic development of subject-specific computer models for the analysis of personalized treatments is currently a reality. In fact, many advances have…”
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Effect of porosity and mineral content on the elastic constants of cortical bone: a multiscale approach by Martínez-Reina, J., Domínguez, J., García-Aznar, J. M.

“…A micromechanical multiscale model which estimates the elastic properties of cortical bone as a function of porosity and mineral content is presented. The…”
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