Effect of folic acid and zinc sulphate on endocrine parameters and seminal antioxidant level after varicocelectomy

Summary Varicocele is among the most common problems which may lead to male infertility. Spermatogenesis is impaired as a consequence of this vascular defect, through mechanisms that are not well described. This study aimed to evaluate serum hormonal level (inhibin B, FSH and testosterone) and semin...

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Published in:	Andrologia Vol. 46; no. 3; pp. 240 - 245
Main Authors:	Nematollahi-Mahani, S. N., Azizollahi, G. H., Baneshi, M. R., Safari, Z., Azizollahi, S.
Format:	Journal Article
Language:	English
Published:	Germany Blackwell Publishing Ltd 01-04-2014 Wiley Subscription Services, Inc
Subjects:	Antioxidants - metabolism Drug Therapy, Combination Folic acid Folic Acid - administration & dosage Folic Acid - therapeutic use Follicle Stimulating Hormone - blood Humans Infertility, Male - drug therapy Infertility, Male - etiology Infertility, Male - metabolism Inhibins - blood Male Nitric Oxide - metabolism Semen - drug effects Semen - metabolism Superoxide Dismutase - metabolism Testosterone - blood varicocele Varicocele - complications Varicocele - drug therapy Varicocele - metabolism Zinc Sulfate - administration & dosage Zinc Sulfate - therapeutic use zinc sulphate zinc sulphate Folic acid varicocele
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Summary:	Summary Varicocele is among the most common problems which may lead to male infertility. Spermatogenesis is impaired as a consequence of this vascular defect, through mechanisms that are not well described. This study aimed to evaluate serum hormonal level (inhibin B, FSH and testosterone) and seminal plasma antioxidant defence levels after folic acid and zinc sulphate administration in varicocelectomised patients. Participants were randomly allocated to four experimental groups. Our randomisation schedule was as follows: zinc sulphate/folic acid, folic acid, zinc sulphate and placebo. The patients underwent varicocelectomy, before which a blood and semen sample were obtained and also three and six months after varicocelectomy for evaluation of blood hormonal level (FSH, testosterone, inhibin B) and seminal oxidative stress status (nitric oxide, superoxide dismutase, total antioxidant capacity). Patients in different groups took orally one capsule per day after dinner following varicocelectomy for 6 months. A significant rise in peripheral blood inhibin B and seminal plasma activity was detected in the zinc sulphate/folic acid group after 6 months. The present clinical trial indicates a change in the hormonal status of varicocelectomised patients following long‐term administration of zinc sulphate and folic acid.
Bibliography:	Kerman University of Medical Sciences ArticleID:AND12067 ark:/67375/WNG-5LW4HCQ2-7 istex:A986E5951367F2F75767FA06536F59817552C9F2 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23
ISSN:	0303-4569 1439-0272
DOI:	10.1111/and.12067