Search Results - "Azevedo, Ricardo B. R."

Genetic drift promotes and recombination hinders speciation on holey fitness landscapes by Kalirad, Ata, Burch, Christina L, Azevedo, Ricardo B R

“…Dobzhansky and Muller proposed a general mechanism through which microevolution, the substitution of alleles within populations, can cause the evolution of…”
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Sexual reproduction selects for robustness and negative epistasis in artificial gene networks by Azevedo, Ricardo B. R, Lohaus, Rolf, Srinivasan, Suraj, Dang, Kristen K, Burch, Christina L

“…The mutational deterministic hypothesis for the origin and maintenance of sexual reproduction posits that sex enhances the ability of natural selection to…”
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Mutational meltdown in asexual populations doomed to extinction by Olofsson, Peter, Chipkin, Logan, Daileda, Ryan C., Azevedo, Ricardo B. R.

“…Asexual populations are expected to accumulate deleterious mutations through a process known as Muller’s ratchet. Lynch and colleagues proposed that the…”
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A branching process model of evolutionary rescue by Azevedo, Ricardo B.R., Olofsson, Peter

“…Evolutionary rescue is the process whereby a declining population may start growing again, thus avoiding extinction, via an increase in the frequency of fitter…”
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npr-1 Regulates Foraging and Dispersal Strategies in Caenorhabditis elegans by Gloria-Soria, Andrea, Azevedo, Ricardo B.R.

“…Wild isolates of Caenorhabditis elegans differ in their tendency to aggregate on food [1, 2]. Most quantitative variation in this behavior is explained by a…”
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The simplicity of metazoan cell lineages by Azevedo, Ricardo B. R, Lohaus, Rolf, Braun, Volker, Gumbel, Markus, Umamaheshwar, Muralikrishna, Agapow, Paul-Michael, Houthoofd, Wouter, Platzer, Ute, Borgonie, Gaëtan, Meinzer, Hans-Peter, Leroi, Armand M

“…Developmental processes are thought to be highly complex, but there have been few attempts to measure and compare such complexity across different groups of…”
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Redundancy and the evolution of cis-regulatory element multiplicity by Paixão, Tiago, Azevedo, Ricardo B R

“…The promoter regions of many genes contain multiple binding sites for the same transcription factor (TF). One possibility is that this multiplicity evolved…”
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TESTING LIFE-HISTORY PLEIOTROPY IN CAENORHABDITIS ELEGANS by Knight, Christopher G, Azevedo, Ricardo B. R, Leroi, Armand M

“…Much life-history theory assumes that alleles segregating in natural populations pleiotropically affect life-history traits. This assumption, while plausible,…”
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Neutral Evolution of Robustness in Drosophila microRNA Precursors by Price, Nicholas, Cartwright, Reed A., Sabath, Niv, Graur, Dan, Azevedo, Ricardo B.R.

“…Mutational robustness describes the extent to which a phenotype remains unchanged in the face of mutations. Theory predicts that the strength of direct…”
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Spiraling Complexity: A Test of the Snowball Effect in a Computational Model of RNA Folding by Kalirad, Ata, Azevedo, Ricardo B R

“…Genetic incompatibilities can emerge as a byproduct of genetic divergence. According to Dobzhansky and Muller, an allele that fixes in one population may be…”
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Sex, amitosis, and evolvability in the ciliate Tetrahymena thermophila by Tarkington, Jason, Zhang, Hao, Azevedo, Ricardo B R, Zufall, Rebecca A

“…Understanding the mechanisms that generate genetic variation, and thus contribute to the process of adaptation, is a major goal of evolutionary biology…”
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On the immortality of television sets: "function" in the human genome according to the evolution-free gospel of ENCODE by Graur, Dan, Zheng, Yichen, Price, Nicholas, Azevedo, Ricardo B R, Zufall, Rebecca A, Elhaik, Eran

“…A recent slew of ENCyclopedia Of DNA Elements (ENCODE) Consortium publications, specifically the article signed by all Consortium members, put forward the idea…”
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Historical Contingency Causes Divergence in Adaptive Expression of the lac Operon by Karkare, Kedar, Lai, Huei-Yi, Azevedo, Ricardo B.R., Cooper, Tim F.

“…Abstract Populations of Escherichia coli selected in constant and fluctuating environments containing lactose often adapt by substituting mutations in the lacI…”
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Thermal Evolution of Egg Size in Drosophila melanogaster by Ricardo B. R. Azevedo, French, Vernon, Partridge, Linda

“…We measured the size of eggs produced by populations of Drosophila melanogaster that had been collected along latitudinal gradients in different continents or…”
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The Evolution of Small-RNA-Mediated Silencing of an Invading Transposable Element by Kelleher, Erin S, Azevedo, Ricardo B R, Zheng, Yichen

“…Transposable elements (TEs) are genomic parasites that impose fitness costs on their hosts by producing deleterious mutations and disrupting gametogenesis…”
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Latitudinal variation of wing:thorax size ratio and wing-aspect ratio Drosophila melanogaster by Azevedo, R.B.R, James, A.C, McCabe, J, Partridge, L

“…In dipterans, the wing-beat frequency, and, hence, the lift generated, increases linearly with ambient temperature. If flight performance is an important…”
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Correlated Selection on Amino Acid Deletion and Replacement in Mammalian Protein Sequences by Zheng, Yichen, Graur, Dan, Azevedo, Ricardo B. R.

“…A low ratio of nonsynonymous and synonymous substitution rates (dN/dS) at a codon is an indicator of functional constraint caused by purifying selection…”
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An evolutionary classification of genomic function by Graur, Dan, Zheng, Yichen, Azevedo, Ricardo B R

“…The pronouncements of the ENCODE Project Consortium regarding "junk DNA" exposed the need for an evolutionary classification of genomic elements according to…”
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Population structure promotes the evolution of costly sex in artificial gene networks by Whitlock, Alexander O. B., Azevedo, Ricardo B. R., Burch, Christina L.

“…We build on previous observations that Hill–Robertson interference generates an advantage of sex that, in structured populations, can be large enough to…”
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accuMUlate: a mutation caller designed for mutation accumulation experiments by Winter, David J, Wu, Steven H, Howell, Abigail A, Azevedo, Ricardo B R, Zufall, Rebecca A, Cartwright, Reed A

“…Abstract Summary Mutation accumulation (MA) is the most widely used method for directly studying the effects of mutation. By sequencing whole genomes from MA…”
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