Green Synthesis of Zinc Oxide Nanoparticles Using Aqueous Extract of Deverra tortuosa and their Cytotoxic Activities

In recent years, there is a growing interest towards the green synthesis of metal nanoparticles, particularly from plants; however, yet no published study on the synthesis of ZnO.NPs using the Deverra tortuosa extract. Through this study, zinc oxide nanoparticles (ZnO.NPs) have been synthesized base...

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Bibliographic Details
Published in:	Scientific reports Vol. 10; no. 1; p. 3445
Main Authors:	Selim, Yasser A., Azb, Maha A., Ragab, Islam, H. M. Abd El-Azim, Mohamed
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 26-02-2020 Nature Publishing Group
Subjects:	140/146 639/638/224/899 692/308/153 Adenocarcinoma Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor activity Cell Line, Tumor Cell Survival - drug effects Chromatography, High Pressure Liquid Colon Colon cancer Cytotoxicity Fourier transforms Green Chemistry Technology Humanities and Social Sciences Humans Infrared spectroscopy Lung cancer Magnoliopsida - chemistry Magnoliopsida - metabolism Metal Nanoparticles - chemistry Metal Nanoparticles - toxicity multidisciplinary Nanoparticles Phenols - chemistry Phenols - pharmacology Plant Components, Aerial - chemistry Plant Components, Aerial - metabolism Plant extracts Plant Extracts - chemistry Science Science (multidisciplinary) Spectrum analysis Tumor cell lines X-ray diffraction Zinc oxide Zinc Oxide - chemistry Zinc oxides
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Summary:	In recent years, there is a growing interest towards the green synthesis of metal nanoparticles, particularly from plants; however, yet no published study on the synthesis of ZnO.NPs using the Deverra tortuosa extract. Through this study, zinc oxide nanoparticles (ZnO.NPs) have been synthesized based on using the environmentally benign extract of the aerial parts of D. tortuosa as a reducing and capping agent. ZnO.NPs synthesis was confirmed using UV-Visible (UV-Vis) spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD) and High Resolution-Transmission Electron Microscope (HR-TEM). The qualitative and quantitative analyses of plant extract were done. The potential anticancer activity was in vitro investigated against two cancer cell lines (human colon adenocarcinoma “Caco-2” and human lung adenocarcinoma “A549”) compared to their activities on the human lung fibroblast cell line (WI38) using the MTT assay. Both the aqueous extract and ZnO.NPs showed a remarkable selective cytotoxicity against the two examined cancer cell lines.
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-020-60541-1