Relationships between phagocytosis, mucoid phenotype, and genetic characteristics of Klebsiella pneumoniae clinical isolates

Relationships between phagocytosis, mucoid phenotype, and genetic characteristics of Klebsiella pneumoniae clinical isolates

The relationships between phagocytosis, and mucoid phenotype, plasmid profile and virulence, and resistance genetic characteristics of Klebsiella pneumoniae clinical isolates were evaluated. Thirty isolates were used to determine the mucoid aspect. Four were selected for analysis of phagocytosis by...

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Bibliographic Details
Published in:Revista da Sociedade Brasileira de Medicina Tropical Vol. 52; p. e20190089B
Main Authors: Cavalcanti, Francinete Carla Nunes, Rodrigues, Juliana Falcão, Cabral, Adriane Borges, Azarias, Larissa Caina Barbosa de, Morais Júnior, Marcos Antônio de, Castro, Célia Maria Machado Barbosa de, Lopes, Ana Catarina de Souza
Format: Journal Article
Language:English
Published: Brazil Sociedade Brasileira de Medicina Tropical - SBMT 01-01-2019
Sociedade Brasileira de Medicina Tropical (SBMT)
Subjects:
Alveolar macrophages
Anti-Bacterial Agents - pharmacology
Drug Resistance, Microbial - genetics
Genetic characteristics
Humans
Klebsiella pneumoniae
Klebsiella pneumoniae - drug effects
Klebsiella pneumoniae - genetics
Klebsiella pneumoniae - pathogenicity
Mucoid phenotype
Phagocytosis
Phagocytosis - genetics
Phagocytosis - physiology
Phenotype
Plasmids
TROPICAL MEDICINE
Virulence - genetics
Virulence Factors - genetics
Genetic characteristics
Mucoid phenotype
Alveolar macrophages
Klebsiella pneumoniae
Phagocytosis
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Summary:The relationships between phagocytosis, and mucoid phenotype, plasmid profile and virulence, and resistance genetic characteristics of Klebsiella pneumoniae clinical isolates were evaluated. Thirty isolates were used to determine the mucoid aspect. Four were selected for analysis of phagocytosis by alveolar macrophages. Thirty percent of the samples presented the mucoid phenotype. The phagocytosis rate ranged from 21.5% to 43.43%. Phagocytosis was not correlated with the plasmid profile, but was apparently correlated with mucoid phenotype and antibiotic susceptibility. Several virulence factors act in parallel in K. pneumoniae to impair host defense.
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ISSN:0037-8682
1678-9849
1678-9849
DOI:10.1590/0037-8682-0089-2019