Search Results - "Azares, Alon R"
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Critical Role of Cytosolic DNA and Its Sensing Adaptor STING in Aortic Degeneration, Dissection, and Rupture
Published in Circulation (New York, N.Y.) (07-01-2020)“…Sporadic aortic aneurysm and dissection (AAD), caused by progressive aortic smooth muscle cell (SMC) loss and extracellular matrix degradation, is a highly…”
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Effect of Ciprofloxacin on Susceptibility to Aortic Dissection and Rupture in Mice
Published in JAMA surgery (01-09-2018)“…Fluoroquinolones are among the most commonly prescribed antibiotics. Recent clinical studies indicated an association between fluoroquinolone use and increased…”
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The Composition of Adipose-Derived Regenerative Cells Isolated from Lipoaspirate Using a Point of Care System Does Not Depend on the Subject's Individual Age, Sex, Body Mass Index and Ethnicity
Published in Cells (Basel, Switzerland) (21-12-2022)“…Uncultured, unmodified, autologous, adipose-derived regenerative cells (UA-ADRCs) are a safe and effective treatment option for various musculoskeletal…”
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AKT2 Promotes Bone Marrow Cell–Mediated Aortic Protection in Mice
Published in The Annals of thoracic surgery (01-06-2016)“…Background Insufficient aortic protection and repair may contribute to the development of aortic aneurysms and dissections (AAD). However, mechanisms of aortic…”
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Celf1 regulates cell cycle and is partially responsible for defective myoblast differentiation in myotonic dystrophy RNA toxicity
Published in Biochimica et biophysica acta (01-07-2015)“…Myotonic dystrophy is a neuromuscular disease of RNA toxicity. The disease gene DMPK harbors expanded CTG trinucleotide repeats on its 3′-UTR. The transcripts…”
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Activation of Bone Marrow–Derived Cells and Resident Aortic Cells During Aortic Injury
Published in The Journal of surgical research (01-01-2020)“…The process of aortic injury, repair, and remodeling during aortic aneurysm and dissection is poorly understood. We examined the activation of bone marrow…”
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Single-Cell Analysis of Aneurysmal Aortic Tissue in Patients with Marfan Syndrome Reveals Dysfunctional TGF-β Signaling
Published in Genes (30-12-2021)“…The molecular and cellular processes leading to aortic aneurysm development in Marfan syndrome (MFS) remain poorly understood. In this study, we examined the…”
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Multidomain peptide hydrogel adjuvants elicit strong bias towards humoral immunity
Published in Biomaterials science (25-10-2022)“…Adjuvants play a critical role in enhancing vaccine efficacy; however, there is a need to develop new immunomodulatory compounds to address emerging pathogens…”
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Abstract 15325: Dynamic Change From Mitochondrial Compensation to Mitochondrial Failure During Aortic Disease Progression and Dissection Formation
Published in Circulation (New York, N.Y.) (08-11-2022)“…IntroductionAscending thoracic aortic aneurysm (ATAA) progression to dissection (ATAD) is associated with a high risk of mortality. Since the specific…”
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