Inhibitory effects of d-mannose on trypanosomatid lysis induced by Serratia marcescens

Inhibitory effects of d-mannose on trypanosomatid lysis induced by Serratia marcescens

Studies were carried out on the effects of different carbohydrates on the lysis of Trypanosoma cruzi, Trypanosoma rangeli and erythocytes caused by the bacteria Serratia marcescens variants SM 365 and RPH. High concentrations of d-mannose were found to protect T. cruzi and T. rangeli markedly dimini...

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Bibliographic Details
Published in:Experimental parasitology Vol. 115; no. 2; pp. 200 - 204
Main Authors: Castro, Daniele P., Moraes, Caroline S., Garcia, Eloi S., Azambuja, Patrı´cia
Format: Journal Article
Language:English
Published: San Diego, CA Elsevier Inc 01-02-2007
Elsevier
Subjects:
Animals
Biological and medical sciences
d-mannose
Erythrocytes - drug effects
Erythrocytes - microbiology
Fimbriae, Bacterial - physiology
Fundamental and applied biological sciences. Psychology
Hemolysis
Hemolysis - drug effects
Humans
Kinetics
Life cycle. Host-agent relationship. Pathogenesis
Mannose - pharmacology
Mannose - physiology
Protozoa
Serratia marcescens
Serratia marcescens - drug effects
Serratia marcescens - pathogenicity
Serratia marcescens - physiology
Trypanosoma cruzi
Trypanosoma cruzi - drug effects
Trypanosoma cruzi - metabolism
Trypanosoma cruzi - microbiology
Trypanosoma rangeli
Hemolysis
Trypanosoma rangeli
d-mannose
Serratia marcescens
Trypanosoma cruzi
Kinetoplastida
Protozoa
Trypanosomatidae
Lysis
Parasite
Bacteria
Mannose
Enterobacteriaceae
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Summary:Studies were carried out on the effects of different carbohydrates on the lysis of Trypanosoma cruzi, Trypanosoma rangeli and erythocytes caused by the bacteria Serratia marcescens variants SM 365 and RPH. High concentrations of d-mannose were found to protect T. cruzi and T. rangeli markedly diminishing the lysis caused by S. marcescens. However, this carbohydrate is unable to interfere with the hemolysis induced by SM 365 and RPH variants. These results showed that the trypanolytic effect induced by S. marcescens SM 365 and RPH variants is dependent on d-mannose and distinct from the hemolytic activity, strongly suggesting that bacterial fimbriae are relevant to S. marcescens in lysis of parasites.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0014-4894
1090-2449
DOI:10.1016/j.exppara.2006.08.001