Luxembourg Parkinson's study -comprehensive baseline analysis of Parkinson's disease and atypical parkinsonism

Deep phenotyping of Parkinson's disease (PD) is essential to investigate this fastest-growing neurodegenerative disorder. Since 2015, over 800 individuals with PD and atypical parkinsonism along with more than 800 control subjects have been recruited in the frame of the observational, monocentr...

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Published in:	Frontiers in neurology Vol. 14; p. 1330321
Main Authors:	Pavelka, Lukas, Rawal, Rajesh, Ghosh, Soumyabrata, Pauly, Claire, Pauly, Laure, Hanff, Anne-Marie, Kolber, Pierre Luc, Jónsdóttir, Sonja R, Mcintyre, Deborah, Azaiz, Kheira, Thiry, Elodie, Vilasboas, Liliana, Soboleva, Ekaterina, Giraitis, Marijus, Tsurkalenko, Olena, Sapienza, Stefano, Diederich, Nico, Klucken, Jochen, Glaab, Enrico, Aguayo, Gloria A, Jubal, Eduardo Rosales, Perquin, Magali, Vaillant, Michel, May, Patrick, Gantenbein, Manon, Satagopam, Venkata P, Krüger, Rejko
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 19-12-2023
Subjects:	environment exposure hyposmia Neurology parkinsonian disorders Parkinson’s disease progressive supranuclear palsy REM-sleep behaviour disorder REM-sleep behaviour disorder parkinsonian disorders Parkinson’s disease environment exposure hyposmia progressive supranuclear palsy
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Summary:	Deep phenotyping of Parkinson's disease (PD) is essential to investigate this fastest-growing neurodegenerative disorder. Since 2015, over 800 individuals with PD and atypical parkinsonism along with more than 800 control subjects have been recruited in the frame of the observational, monocentric, nation-wide, longitudinal-prospective Luxembourg Parkinson's study. To profile the baseline dataset and to explore risk factors, comorbidities and clinical profiles associated with PD, atypical parkinsonism and controls. Epidemiological and clinical characteristics of all 1,648 participants divided in disease and control groups were investigated. Then, a cross-sectional group comparison was performed between the three largest groups: PD, progressive supranuclear palsy (PSP) and controls. Subsequently, multiple linear and logistic regression models were fitted adjusting for confounders. The mean (SD) age at onset (AAO) of PD was 62.3 (11.8) years with 15% early onset (AAO < 50 years), mean disease duration 4.90 (5.16) years, male sex 66.5% and mean MDS-UPDRS III 35.2 (16.3). For PSP, the respective values were: 67.6 (8.2) years, all PSP with AAO > 50 years, 2.80 (2.62) years, 62.7% and 53.3 (19.5). The highest frequency of hyposmia was detected in PD followed by PSP and controls (72.9%; 53.2%; 14.7%), challenging the use of hyposmia as discriminating feature in PD vs. PSP. Alcohol abstinence was significantly higher in PD than controls (17.6 vs. 12.9%, = 0.003). Luxembourg Parkinson's study constitutes a valuable resource to strengthen the understanding of complex traits in the aforementioned neurodegenerative disorders. It corroborated several previously observed clinical profiles, and provided insight on frequency of hyposmia in PSP and dietary habits, such as alcohol abstinence in PD. : clinicaltrials.gov, NCT05266872.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Alberto J. Espay, University of Cincinnati, United States; Ivan G. Milanov, Multiprofile Hospital for Active Treatment in Neurology and Psychiatry St. Naum, Bulgaria Edited by: Genko Oyama, Juntendo University, Japan These authors share first authorship
ISSN:	1664-2295 1664-2295
DOI:	10.3389/fneur.2023.1330321