Search Results - "Azad, Mohammad A."

Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials-Process Perspective by Azad, Mohammad A, Olawuni, Deborah, Kimbell, Georgia, Badruddoza, Abu Zayed Md, Hossain, Md Shahadat, Sultana, Tasnim

“…Three dimensional (3D) printing as an advanced manufacturing technology is progressing to be established in the pharmaceutical industry to overcome the…”
Get full text

A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens by Roberts, Kade D., Zhu, Yan, Azad, Mohammad A. K., Han, Mei-Ling, Wang, Jiping, Wang, Lynn, Yu, Heidi H., Horne, Andrew S., Pinson, Jo-Anne, Rudd, David, Voelcker, Nicolas H., Patil, Nitin A., Zhao, Jinxin, Jiang, Xukai, Lu, Jing, Chen, Ke, Lomovskaya, Olga, Hecker, Scott J., Thompson, Philip E., Nation, Roger L., Dudley, Michael N., Griffith, David C., Velkov, Tony, Li, Jian

“…The emergence of multidrug-resistant (MDR) Gram-negative pathogens is an urgent global medical challenge. The old polymyxin lipopeptide antibiotics (polymyxin…”
Get full text

Major pathways of polymyxin-induced apoptosis in rat kidney proximal tubular cells by Azad, Mohammad A K, Akter, Jesmin, Rogers, Kelly L, Nation, Roger L, Velkov, Tony, Li, Jian

“…Identifying the pathways involved in the apoptotic cell death that is associated with polymyxin-induced nephrotoxicity is crucial for the development of…”
Get full text

Polymyxin B Induces Apoptosis in Kidney Proximal Tubular Cells by AZAD, Mohammad A. K, FINNIN, Ben A, POUDYAL, Anima, DAVIS, Kathryn, JINHUA LI, HILL, Prue A, NATION, Roger L, VELKOV, Tony, JIAN LI

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Potential Toxicity of Polymyxins in Human Lung Epithelial Cells by Ahmed, Maizbha U, Velkov, Tony, Lin, Yu-Wei, Yun, Bo, Nowell, Cameron J, Zhou, Fanfan, Zhou, Qi Tony, Chan, Kim, Azad, Mohammad A K, Li, Jian

“…Inhaled polymyxins are of considerable utility in achieving optimal exposure in the respiratory tract for the treatment of lung infections caused by…”
Get full text

Improved Aerosolization Stability of Inhalable Tobramycin Powder Formulation by Co-Spray Drying with Colistin by Pathak, Vaibhav, Park, Heejun, Zemlyanov, Dmitry, Bhujbal, Sonal V., Ahmed, Maizbha Uddin, Azad, Mohammad A. K., Li, Jian, Zhou, Qi Tony

“…Purpose Tobramycin shows synergistic antibacterial activity with colistin and can reduce the toxic effects of colistin. The purpose of this study is to prepare…”
Get full text

Hybrid motility mechanism of sperm at viscoelastic fluid-solid interface by Unnikrishnan, Shobitha, Scott, Robert L, Ogundele, Emmanuel, Azad, Mohammad A, Ishimoto, Kenta, Suarez, Susan S., Tung, Chih Kuan

“…To fertilize eggs, sperm must pass through narrow, complex channels filled with viscoelastic fluids in the female reproductive tract. While it is known that…”
Get full text

Antimicrobial Activity and Toxicity of the Major Lipopeptide Components of Polymyxin B and Colistin: Last-Line Antibiotics against Multidrug-Resistant Gram-Negative Bacteria by Roberts, Kade D, Azad, Mohammad A. K, Wang, Jiping, Horne, Andrew S, Thompson, Philip E, Nation, Roger L, Velkov, Tony, Li, Jian

“…Polymyxin B and colistin are currently used as a “last-line” treatment for multidrug-resistant Gram-negative bacteria. However, very little is known about the…”
Get full text

Polymyxin-Induced Cell Death of Human Macrophage-Like THP-1 and Neutrophil-Like HL-60 Cells Associated with the Activation of Apoptotic Pathways by Fathalla, Ahmed M, Chow, Seong H, Naderer, Thomas, Zhou, Qi Tony, Velkov, Tony, Azad, Mohammad A K, Li, Jian

“…Innate immunity is crucial for the host to defend against infections, and understanding the effect of polymyxins on innate immunity is important for optimizing…”
Get full text

Correlative proteomics identify the key roles of stress tolerance strategies in Acinetobacter baumannii in response to polymyxin and human macrophages by Kho, Zhi Ying, Azad, Mohammad A K, Han, Mei-Ling, Zhu, Yan, Huang, Cheng, Schittenhelm, Ralf B, Naderer, Thomas, Velkov, Tony, Selkrig, Joel, Zhou, Qi Tony, Li, Jian

“…The opportunistic pathogen Acinetobacter baumannii possesses stress tolerance strategies against host innate immunity and antibiotic killing. However, how the…”
Get full text

Probing the Penetration of Antimicrobial Polymyxin Lipopeptides into Gram-Negative Bacteria by Deris, Zakuan Z, Swarbrick, James D, Roberts, Kade D, Azad, Mohammad A. K, Akter, Jesmin, Horne, Andrew. S, Nation, Roger L, Rogers, Kelly L, Thompson, Phillip E, Velkov, Tony, Li, Jian

“…The dry antibiotic development pipeline coupled with the emergence of multidrug resistant Gram-negative ‘superbugs’ has driven the revival of the polymyxin…”
Get full text

Inwardly rectifying potassium channels mediate polymyxin-induced nephrotoxicity by Lu, Jing, Azad, Mohammad A. K., Moreau, Julie L. M., Zhu, Yan, Jiang, Xukai, Tonta, Mary, Lam, Rachel, Wickremasinghe, Hasini, Zhao, Jinxin, Wang, Jiping, Coleman, Harold A., Formosa, Luke E., Velkov, Tony, Parkington, Helena C., Combes, Alexander N., Rosenbluh, Joseph, Li, Jian

“…Polymyxin antibiotics are often used as a last-line defense to treat life-threatening Gram-negative pathogens. However, polymyxin-induced kidney toxicity is a…”
Get full text

Polymyxin-Induced Metabolic Perturbations in Human Lung Epithelial Cells by Ahmed, Maizbha U, Azad, Mohammad A K, Li, Mengyao, Creek, Darren J, Han, Meiling, Zhou, Fanfan, Chan, Kim, Zhou, Qi Tony, Velkov, Tony, Li, Jian

“…Inhaled polymyxins are associated with toxicity in human lung epithelial cells that involves multiple apoptotic pathways. However, the mechanism of…”
Get full text

Significant Accumulation of Polymyxin in Single Renal Tubular Cells: A Medicinal Chemistry and Triple Correlative Microscopy Approach by Azad, Mohammad A. K, Roberts, Kade D, Yu, Heidi H, Liu, Boyin, Schofield, Alice V, James, Simon A, Howard, Daryl L, Nation, Roger L, Rogers, Kelly, de Jonge, Martin D, Thompson, Philip E, Fu, Jing, Velkov, Tony, Li, Jian

“…Polymyxin is the last-line therapy against Gram-negative ‘superbugs’; however, dose-limiting nephrotoxicity can occur in up to 60% of patients after…”
Get full text

Methionine Ameliorates Polymyxin-Induced Nephrotoxicity by Attenuating Cellular Oxidative Stress by Azad, Mohammad A K, Sivanesan, Sivashangarie, Wang, Jiping, Chen, Ke, Nation, Roger L, Thompson, Philip E, Roberts, Kade D, Velkov, Tony, Li, Jian

“…Polymyxins are a last line of defense against multidrug-resistant Gram-negative pathogens. Recent pharmacological data show that intravenous polymyxins can…”
Get full text

Cellular Uptake and Localization of Polymyxins in Renal Tubular Cells Using Rationally Designed Fluorescent Probes by Yun, Bo, Azad, Mohammad A K, Nowell, Cameron J, Nation, Roger L, Thompson, Philip E, Roberts, Kade D, Velkov, Tony, Li, Jian

“…Polymyxins are cyclic lipopeptide antibiotics that serve as a last line of defense against Gram-negative bacterial superbugs. However, the extensive…”
Get full text

Gelofusine Ameliorates Colistin-Induced Nephrotoxicity by Sivanesan, Sivashangarie S, Azad, Mohammad A K, Schneider, Elena K, Ahmed, Maizbha U, Huang, Jiayuan, Wang, Jiping, Li, Jian, Nation, Roger L, Velkov, Tony

“…Colistin therapy is used as the last line of defense against life-threatening Gram-negative infections. Nephrotoxicity is the major dose-limiting side effect…”
Get full text

Transcriptomic Responses to Polymyxin B and Analogues in Human Kidney Tubular Cells by Li, Mengyao, Azad, Mohammad A K, Thompson, Philip E, Roberts, Kade D, Velkov, Tony, Zhu, Yan, Li, Jian

“…Polymyxins are last-line antibiotics for the treatment of Gram-negative 'superbugs'. However, nephrotoxicity can occur in up to 60% of patients administered…”
Get full text

Imaging the distribution of polymyxins in the kidney by Yun, Bo, Azad, Mohammad A K, Wang, Jiping, Nation, Roger L, Thompson, Philip E, Roberts, Kade D, Velkov, Tony, Li, Jian

“…Dose-limiting nephrotoxicity remains the Achilles' heel of polymyxin B and polymyxin E (also known as colistin), which are important last-line antibiotics used…”
Get full text

A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threatening Acinetobacter baumannii by Jiang, Xukai, Patil, Nitin A, Azad, Mohammad A K, Wickremasinghe, Hasini, Yu, Heidi, Zhao, Jinxin, Zhang, Xinru, Li, Mengyao, Gong, Bin, Wan, Lin, Ma, Wendong, Thompson, Philip E, Yang, Kai, Yuan, Bing, Schreiber, Falk, Wang, Lushan, Velkov, Tony, Roberts, Kade D, Li, Jian

“…Multidrug-resistant Gram-negative bacteria represent a major medical challenge worldwide. New antibiotics are desperately required with 'old' polymyxins often…”
Get full text