Search Results - "Azab, Belal"

Therapy-Induced Senescence: An "Old" Friend Becomes the Enemy by Saleh, Tareq, Bloukh, Sarah, Carpenter, Valerie J, Alwohoush, Enas, Bakeer, Jomana, Darwish, Sarah, Azab, Belal, Gewirtz, David A

“…For the past two decades, cellular senescence has been recognized as a central component of the tumor cell response to chemotherapy and radiation…”
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PKM2 and HIF-1α regulation in prostate cancer cell lines by Hasan, Diya, Gamen, Elisabetta, Abu Tarboush, Nafez, Ismail, Yazan, Pak, Oleg, Azab, Belal

“…Prostate cancer (PCA) is one of the most common cancer types in men, with cancer progression being linked to hypoxia and the induction of hypoxia-inducible…”
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The potential of celecoxib-loaded hydroxyapatite-chitosan nanocomposite for the treatment of colon cancer by Venkatesan, P, Puvvada, Nagaprasad, Dash, Rupesh, Prashanth Kumar, B.N, Sarkar, Devanand, Azab, Belal, Pathak, Amita, Kundu, Subhas C, Fisher, Paul B, Mandal, Mahitosh

“…Abstract Celecoxib has shown potential anticancer activity against most carcinomas, especially in patients with familial adenomatous polyposis and precancerous…”
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Targeted apoptotic effects of thymoquinone and tamoxifen on XIAP mediated Akt regulation in breast cancer by Rajput, Shashi, Kumar, B N Prashanth, Sarkar, Siddik, Das, Subhasis, Azab, Belal, Santhekadur, Prasanna K, Das, Swadesh K, Emdad, Luni, Sarkar, Devanand, Fisher, Paul B, Mandal, Mahitosh

“…X-linked inhibitor of apoptosis protein (XIAP) is constitutively expressed endogenous inhibitor of apoptosis, exhibit its antiapoptotic effect by inactivating…”
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Identification of APTX disease-causing mutation in two unrelated Jordanian families with cerebellar ataxia and sensitivity to DNA damaging agents by Ababneh, Nidaa A, Ali, Dema, Al-Kurdi, Ban, Sallam, Malik, Alzibdeh, Abdulla M, Salah, Bareqa, Ryalat, Abdee T, Azab, Belal, Sharrack, Basil, Awidi, Abdalla

“…Background Ataxia with oculomotor apraxia type 1 (AOA1) is a rare autosomal recessive cerebellar ataxia, caused by mutations in the APTX gene. The disease is…”
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MDA-9/Syntenin and IGFBP-2 Promote Angiogenesis in Human Melanoma by DAS, Swadesh K, BHUTIA, Sujit K, EMDAD, Luni, PELLECCHIA, Maurizio, SARKAR, Devanand, FISHER, Paul B, AZAB, Belal, KEGELMAN, Timothy P, PEACHY, Leyla, SANTHEKADUR, Prasanna K, DASGUPTA, Santanu, DASH, Rupesh, DENT, Paul, GRANT, Steven

“…Melanoma differentiation-associated gene-9 (mda-9/syntenin) encodes an adapter scaffold protein whose expression correlates with and mediates melanoma…”
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Astrocyte elevated gene-1 induces protective autophagy by Bhutia, Sujit K., Kegelman, Timothy P., Das, Swadesh K., Azab, Belal, Su, Zhao-zhong, Lee, Seok-Geun, Sarkar, Devanand, Fisher, Paul B., Cavenee, Webster K.

“…Astrocyte-elevated gene-1 (AEG-1) expression increases in multiple cancers and plays a crucial role in oncogenic transformation and angiogenesis, which are…”
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Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity by Dash, Rupesh, Azab, Belal, Quinn, Bridget A, Shen, Xuening, Wang, Xiang-Yang, Das, Swadesh K, Rahmani, Mohamed, Wei, Jun, Hedvat, Michael, Dent, Paul, Dmitriev, Igor P, Curiel, David T, Grant, Steven, Wu, Bainan, Stebbins, John L, Pellecchia, Maurizio, Reed, John C, Sarkar, Devanand, Fisher, Paul B

“…Limited options are available for treating patients with advanced prostate cancer (PC). Melanoma differentiation associated gene-7/interleukin-24…”
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Human polynucleotide phosphorylase selectively and preferentially degrades microRNA-221 in human melanoma cells by Das, Swadesh K., Sokhi, Upneet K., Bhutia, Sujit K., Azab, Belal, Su, Zhao-zhong, Sarkar, Devanand, Fisher, Paul B., Croce, Carlo M.

“…MicroRNAs (miRNA), small noncoding RNAs, affect a broad range of biological processes, including tumorigenesis, by targeting gene products that directly…”
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Associations of CYP2A6 Gene Polymorphism with Smoking Status Among Jordanians: Gender-Related Differences by Hammad, Hana M, Imraish, Amer, Azab, Belal, Best, Al M, Khader, Yousef S, Zihlif, Malek

“…Cytochrome P450 2A6 enzyme (CYP2A6), an essential hepatic enzyme involved in the metabolism of drugs, is responsible for a major metabolic pathway of nicotine…”
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Effects of Dual Peroxisome Proliferator-Activated Receptors α and γ Activation in Two Rat Models of Neuropathic Pain by El-Salem, Khalid, Dweik, Aala, Azab, Belal, Kalbouneh, Heba, Aldossary, Sara A., Haddad, Mansour, Alsalem, Mohammad, Imraish, Amer

“…Neuropathic pain is a growing healthcare problem causing a global burden. Currently used analgesics such as opioids are associated with adverse effects; urging…”
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mda- 7/IL-24: A unique member of the IL-10 gene family promoting cancer-targeted toxicity by Dash, Rupesh, Bhutia, Sujit K, Azab, Belal, Su, Zhao-zhong, Quinn, Bridget A, Kegelmen, Timothy P, Das, Swadesh K, Kim, Keetae, Lee, Seok-Geun, Park, Margaret A, Yacoub, Adly, Rahmani, Mohammed, Emdad, Luni, Dmitriev, Igor P, Wang, Xiang-Yang, Sarkar, Devanand, Grant, Steven, Dent, Paul, Curiel, David T, Fisher, Paul B

“…Abstract Melanoma differentiation associated gene-7/interleukin-24 ( mda- 7/IL-24) is a unique member of the IL-10 gene family that displays nearly ubiquitous…”
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Analgesic Effects and Impairment in Locomotor Activity Induced by Cannabinoid/Opioid Combinations in Rat Models of Chronic Pain by Alsalem, Mohammad, Altarifi, Ahmad, Haddad, Mansour, Azab, Belal, Kalbouneh, Heba, Imraish, Amer, Saleh, Tareq, El-Salem, Khalid

“…Both opioids and cannabinoids have well-known antinociceptive effects in different animal models of chronic pain. However, unwanted side effects limit their…”
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Enhanced Prostate Cancer Gene Transfer and Therapy Using a Novel Serotype Chimera Cancer Terminator Virus (Ad.5/3-CTV) by Azab, Belal M., Dash, Rupesh, Das, Swadesh K., Bhutia, Sujit K., Sarkar, Siddik, Shen, Xue-Ning, Quinn, Bridget A., Dent, Paul, Dmitriev, Igor P., Wang, Xiang-Yang, Curiel, David T., Pellecchia, Maurizio, Reed, John C., Sarkar, Devanand, Fisher, Paul B.

“…Few options are available for treating patients with advanced prostate cancer (PC). As PC is a slow growing disease and accessible by ultrasound, gene therapy…”
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Autophagy switches to apoptosis in prostate cancer cells infected with melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) by Bhutia, Sujit K., Das, Swadesh K., Azab, Belal, Dash, Rupesh, Su, Zhao-Zhong, Lee, Seok-Geun, Dent, Paul, Curiel, David T., Sarkar, Devanand, Fisher, Paul B.

“…MDA-7/IL-24 has noteworthy potential as an anticancer therapeutic because of its diversity of antitumor properties, its lack of toxicity toward normal cells…”
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Extending the spectrum of CLRN1‐ and ABCA4‐associated inherited retinal dystrophies caused by novel and recurrent variants using exome sequencing by Abu‐Ameerh, Mohammed, Mohammad, Hashim, Dardas, Zain, Barham, Raghda, Ali, Dema, Bijawi, Maysa, Tawalbeh, Mohamed, Amr, Sami, Hatmal, Ma'mon M., Al‐Bdour, Muawyah, Awidi, Abdalla, Azab, Belal

“…Background Inherited retinal dystrophies (IRDs) are characterized by extreme genetic and clinical heterogeneity. There are many genes that are known to cause…”
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Novel frameshift variant in the IDUA gene underlies Mucopolysaccharidoses type I in a consanguineous Yemeni pedigree by Azab, Belal, Dardas, Zain, Hamarsheh, Mohannad, Alsalem, Mohammad, Kilani, Zaid, Kilani, Farah, Awidi, Abdalla, Jafar, Hanan, Amr, Sami

“…Mucopolysaccharidosis type I (MPS I) is an autosomal recessive storage disorder that result as a consequence of a deficiency in the lysosomal hydrolase,…”
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Astrocyte elevated gene-1 activates AMPK in response to cellular metabolic stress and promotes protective autophagy by Bhutia, Sujit K., Kegelman, Timothy P., Das, Swadesh K., Azab, Belal, Su, Zhao-Zhong, Lee, Seok-Geun, Sarkar, Devanand, Fisher, Paul B.

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BRCA1 and BRCA2 genes mutations among high risk breast cancer patients in Jordan by Abu-Helalah, Munir, Azab, Belal, Mubaidin, Rasmi, Ali, Dema, Jafar, Hanan, Alshraideh, Hussam, Drou, Nizar, Awidi, Abdalla

“…Familial breast cancer is estimated to account for 15–20% of all cases of breast cancer. Surveillance for familial breast cancer is well-established…”
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The role of transient receptor potential vanilloid receptor 1 and peroxisome proliferator-activated receptors-α in mediating the antinociceptive effects of palmitoylethanolamine in rats by Aldossary, Sara A, Alsalem, Mohammad, Kalbouneh, Heba, Haddad, Mansour, Azab, Belal, Al-shboul, Othman, Mustafa, Ayman G, Obiedat, Sarah, El-Salem, Khalid

“…Palmitoylethanolamine (PEA) is a ligand at peroxisome proliferator-activated receptors-α (PPARα), a nuclear receptor that has anti-inflammatory effects…”
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