Search Results - "Azab, Adel"

Design, synthesis, antitumor, and VEGFR-2 inhibition activities of novel 4-anilino-2-vinyl-quinazolines: Molecular modeling studies by Hamdi, Abdelrahman, El-Shafey, Hamed W., Othman, Dina I.A., El-Azab, Adel S., AlSaif, Nawaf A., Abdel-Aziz, Alaa A.-M.

“…Compounds 8h, 8l, and 8r exhibited strong antitumor activity against the used tumor cell lines. Compounds 8h, and 8l displayed the highest inhibitory activity…”
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Synthesis of hapten, generation of specific polyclonal antibody and development of ELISA with high sensitivity for therapeutic monitoring of crizotinib by Al-Shehri, Mona M, El-Azab, Adel S, El-Gendy, Manal A, Hamidaddin, Mohammed A, Darwish, Ibrahim A

“…Crizotinib (CZT) is a potent drug used for treatment of non-small cell lung cancer (NSCLC); however, its circulating concentration variability has been…”
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Design, synthesis of 2,3-disubstitued 4(3H)-quinazolinone derivatives as anti-inflammatory and analgesic agents: COX-1/2 inhibitory activities and molecular docking studies by Abdel-Aziz, Alaa A.-M., Abou-Zeid, Laila A., ElTahir, Kamal Eldin H., Mohamed, Menshawy A., Abu El-Enin, Mohamed A., El-Azab, Adel S.

“…Compounds 4 and 6 possessed more potent analgesic and anti-inflammatory activities than celecoxib. Compounds 4 and 6 showed high COX-2 inhibitory efficacies…”
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Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 (COX-2) inhibitors: Anti-inflammatory and analgesic activities by Alanazi, Amer M., El-Azab, Adel S., Al-Suwaidan, Ibrahim A., ElTahir, Kamal Eldin H., Asiri, Yousif A., Abdel-Aziz, Naglaa I., Abdel-Aziz, Alaa A.-M.

“…A group of 30 cyclic imides (1–10a-c) was designed for evaluation as a selective COX-2 inhibitor and investigated in vivo for anti-inflammatory and analgesic…”
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Synthesis and antitumor evaluation of trimethoxyanilides based on 4(3H)-quinazolinone scaffolds by Mohamed, Menshawy A., Ayyad, Rezk R., Shawer, Taghreed Z., Abdel-Aziz, Alaa A.-M., El-Azab, Adel S.

“…A novel series of 2-[(3-substituted-4(3H)-quinazolin-2-yl)thio]-N-(3,4,5-trimethoxyphenyl)acetamide (15–21) and…”
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Synthesis and anti-inflammatory activity of sulfonamides and carboxylates incorporating trimellitimides: Dual cyclooxygenase/carbonic anhydrase inhibitory actions by Abdel-Aziz, Alaa A.-M., Angeli, Andrea, El-Azab, Adel S., Hammouda, Mohammed E.A., El-Sherbeny, Magda A., Supuran, Claudiu T.

“…[Display omitted] •Synthesis of trimellitimides incorporating benzenesulfonamides and carboxylates.•Anti-inflammatory, ulcerogenic and cyctotoxic activities…”
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Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibitory activities and molecular docking studies of substituted 2-mercapto-4(3H)-quinazolinones by Abdel-Aziz, Alaa A.-M., Abou-Zeid, Laila A., ElTahir, Kamal Eldin H., Ayyad, Rezk R., El-Sayed, Magda A.-A., El-Azab, Adel S.

“…A new series of 2-substituted mercapto-4(3H)-quinazolinone 1–26 were synthesized and assessed for in vivo anti-inflammatory and analgesic activities and…”
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Design, synthesis, and antitumor activity of novel compounds based on 1,2,4-triazolophthalazine scaffold: Apoptosis-inductive and PCAF-inhibitory effects by Turky, Abdallah, Bayoumi, Ashraf H., Ghiaty, Adel, El-Azab, Adel S., A.-M. Abdel-Aziz, Alaa, Abulkhair, Hamada S.

“…[Display omitted] •Triazolophthalazines (L-45 analogues) 10–32 were synthesized.•The antitumor activity was evaluated.•The antitumor activity was compared to…”
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Synthesis, Cytotoxic Evaluation, and Structure-Activity Relationship of Substituted Quinazolinones as Cyclin-Dependent Kinase 9 Inhibitors by Alkahtani, Hamad M, Zen, Amer Alhaj, Obaidullah, Ahmad J, Alanazi, Mohammed M, Almehizia, Abdulrahman A, Ansari, Siddique Akber, Aleanizy, Fadilah Sfouq, Alqahtani, Fulwah Yahya, Aldossari, Rana M, Algamdi, Raghad Abdullah, Al-Rasheed, Lamees S, Abdel-Hamided, Sami G, Abdel-Aziz, Alaa A-M, El-Azab, Adel S

“…Cyclin-dependent kinase 9 (CDK9) plays a critical role in transcriptional elongation, through which short-lived antiapoptotic proteins are overexpressed and…”
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Design, synthesis and biological evaluation of 2-mercapto-3-phenethylquinazoline bearing anilide fragments as potential antitumor agents: Molecular docking study by Al-Suwaidan, Ibrahim A., Alanazi, Amer M., Abdel-Aziz, Alaa A.-M., Mohamed, Menshawy A., El-Azab, Adel S.

“…Compounds 15, 16 and 19 possessed the most remarkable broad-spectrum antitumor activities, additionally; compound 15 almost sevenfold more active than the…”
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Design and synthesis of novel 7-aminoquinazoline derivatives: Antitumor and anticonvulsant activities by El-Azab, Adel S., ElTahir, Kamal E.H.

“…Compound 7 showed broad-spectrum antitumor activity, while compound 15 showed advanced anticonvulsant activity as well as lower toxicity than reference drugs…”
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Structural alterations based on naproxen scaffold: Synthesis, evaluation of antitumor activity and COX-2 inhibition, and molecular docking by El-Husseiny, Walaa M., El-Sayed, Magda A.-A., Abdel-Aziz, Naglaa I., El-Azab, Adel S., Asiri, Yousif A., Abdel-Aziz, Alaa A.-M.

“…A new series of non-carboxylic naproxen analogues, bearing a variety of ring systems, such as oxadiazoles 3a–c and 6a–c, cycloalkanes 4a–d, cyclic imides 5a–c,…”
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Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study by El-Sayed, Magda A.-A., Abdel-Aziz, Naglaa I., Abdel-Aziz, Alaa A.-M., El-Azab, Adel S., Asiri, Yousif A., ElTahir, Kamal E.H.

“…A series of hydrazone and pyrazole derivatives were prepared and evaluated for their anti-inflammatory activities and selectivity as COX-2 inhibitor. New…”
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Synergistic Anti Leukemia Effect of a Novel Hsp90 and a Pan Cyclin Dependent Kinase Inhibitors by Abdalla, Ashraf N, Abdallah, Mohamed E, Aslam, Akhmed, Bader, Ammar, Vassallo, Antonio, Tommasi, Nunziatina De, Malki, Waleed H, Gouda, Ahmed M, Mukhtar, Mohammed H, El-Readi, Mahmoud Zaki, Alkahtani, Hamad M, Abdel-Aziz, Alaa A-M, El-Azab, Adel S

“…Acute myeloid leukemia (AML) is among the top four malignancies in Saudi nationals, and it is the top leukemia subtype worldwide. Resistance to available AML…”
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Carbonic Anhydrase Inhibition Activities of Schiff's Bases Based on Quinazoline-Linked Benzenesulfonamide by El-Azab, Adel S, Abdel-Aziz, Alaa A-M, Ghabbour, Hazem A, Bua, Silvia, Nocentini, Alessio, Alkahtani, Hamad M, Alsaif, Nawaf A, Al-Agamy, Mohamed H M, Supuran, Claudiu T

“…Human carbonic anhydrase (CA, EC 4.2.1.1) (hCA) isoforms I, II, IX, and XII were investigated for their inhibitory activity with a series of new Schiff's bases…”
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Synthesis and biological evaluation of 2-styrylquinolines as antitumour agents and EGFR kinase inhibitors: molecular docking study by El-Sayed, Magda A.-A., El-Husseiny, Walaa M., Abdel-Aziz, Naglaa I., El-Azab, Adel S., Abuelizz, Hatem A., Abdel-Aziz, Alaa A.-M.

“…A new series of 4,6-disubstituted 2-(4-(dimethylamino)styryl)quinoline 4a,b-9a,b was synthesized by the reaction of 2-(4-(dimethylamino)styryl)-6-substituted…”
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A Liquid Chromatography Tandem Mass Spectrometry Method for the Simultaneous Estimation of the Dopamine Receptor Antagonist LE300 and Its N-methyl Metabolite in Plasma: Application to a Pharmacokinetic Study by Hefnawy, Mohamed M, Attwa, Mohamed W, Alzamil, Adeeba A, El-Gendy, Manal A, El-Azab, Adel S, Jardan, Yousef A Bin, El-Gamal, Ali A

“…LE300 is a novel dopamine receptor antagonist used to treat cocaine addiction. In the current study, a sensitive and fast liquid chromatography-tandem mass…”
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A Rapid and Sensitive Liquid Chromatography-Tandem Mass Spectrometry Bioanalytical Method for the Quantification of Encorafenib and Binimetinib as a First-Line Treatment for Advanced (Unresectable or Metastatic) Melanoma-Application to a Pharmacokinetic Study by Hefnawy, Mohamed M, Alanazi, Mohammed M, Al-Hossaini, Abdullah M, Alnasser, Abdulaziz I, El-Azab, Adel S, Jardan, Yousef A Bin, Attwa, Mohamed W, El-Gendy, Manal A

“…The combination regimen targeting BRAF and MEK inhibition, for instance, encorafenib (Braftovi , ENF) plus binimetinib (Mektovi , BNB), are now recommended as…”
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Synthesis, potential antitumor activity, cell cycle analysis, and multitarget mechanisms of novel hydrazones incorporating a 4-methylsulfonylbenzene scaffold: a molecular docking study by Abdel-Aziz, Alaa A.-M., El-Azab, Adel S., AlSaif, Nawaf A., Obaidullah, Ahmad J., Al-Obaid, Abdulrahman M., Al-Suwaidan, Ibrahim A.

“…Hydrazone is a bioactive pharmacophore that can be used to design antitumor agents. We synthesised a series of hydrazones (compounds 4-24) incorporating a…”
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Synthesis, enzyme inhibition assay, and molecular modeling study of novel pyrazolines linked to 4-methylsulfonylphenyl scaffold: antitumor activity and cell cycle analysis by Abdel-Aziz, Alaa A.-M, El-Azab, Adel S, Brogi, Simone, Ayyad, Rezk R, Alkahtani, Hamad M, Abuelizz, Hatem A, Al-Suwaidan, Ibrahim A, Al-Obaid, Abdulrahman M

“…Antitumor activity using 59 cancer cell lines and enzyme inhibitory activity of a newly synthesized pyrazoline-linked 4-methylsulfonylphenyl scaffold…”
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