Search Results - "Ayuso, José M"

Microfluidic lumen-based systems for advancing tubular organ modeling by Virumbrales-Muñoz, María, Ayuso, José M, Gong, Max M, Humayun, Mouhita, Livingston, Megan K, Lugo-Cintrón, Karina M, McMinn, Patrick, Álvarez-García, Yasmín R, Beebe, David J

“…Microfluidic lumen-based systems are microscale models that recapitulate the anatomy and physiology of tubular organs. These technologies can mimic human…”
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Breast Fibroblasts and ECM Components Modulate Breast Cancer Cell Migration Through the Secretion of MMPs in a 3D Microfluidic Co-Culture Model by Lugo-Cintrón, Karina M, Gong, Max M, Ayuso, José M, Tomko, Lucas A, Beebe, David J, Virumbrales-Muñoz, María, Ponik, Suzanne M

“…The extracellular matrix (ECM) composition greatly influences cancer progression, leading to differential invasion, migration, and metastatic potential. In…”
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Primary head and neck tumour-derived fibroblasts promote lymphangiogenesis in a lymphatic organotypic co-culture model by Lugo-Cintrón, Karina M., Ayuso, José M., Humayun, Mouhita, Gong, Max M., Kerr, Sheena C., Ponik, Suzanne M., Harari, Paul M., Virumbrales-Muñoz, María, Beebe, David J.

“…In head and neck cancer, intratumour lymphatic density and tumour lymphangiogenesis have been correlated with lymphatic metastasis, making lymphangiogenesis a…”
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Improved Anti-Tumor Activity of Novel Highly Bioactive Liposome-Bound TRAIL in Breast Cancer Cells by De Miguel, Diego, Gallego-Lleyda, Ana, Ayuso, José M, Pawlak, Aleksandra, Conde, Blanca, Ochoa, Ignacio, Fernández, Luis J, Anel, Alberto, Martinez-Lostao, Luis

“…Apo2-ligand/TRAIL, a member of the TNF cytokine superfamily capable of inducing apoptosis on tumor cells while sparing normal cells, is a promising anti-tumor…”
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Tau protein provides DNA with thermodynamic and structural features which are similar to those found in histone-DNA complex by Camero, Sergio, Benítez, María J, Barrantes, Alejandro, Ayuso, José M, Cuadros, Raquel, Avila, Jesús, Jiménez, Juan S

“…Tau protein has been proposed as a trigger of Alzheimer's disease once it is hyperphosphorylated. However, the role that native tau forms play inside the…”
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Behavior of Vine Varieties Resistant to Fungal Diseases in the Somontano Region by Casanova-Gascón, José, Ferrer-Martín, Carla, Bernad-Eustaquio, Antonio, Elbaile-Mur, Andrea, Ayuso-Rodríguez, José M., Torres-Sánchez, Sergio, Jarne-Casasús, Adrián, Martín-Ramos, Pablo

“…The vine is highly susceptible to numerous fungal diseases, the incidence and severity of which are increasing because of climate change. To fight them, large…”
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A role for microfluidic systems in precision medicine by Ayuso, Jose M., Virumbrales-Muñoz, María, Lang, Joshua M., Beebe, David J.

“…Precision oncology continues to challenge the “one-size-fits-all” dogma. Under the precision oncology banner, cancer patients are screened for molecular tumor…”
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Matrix density drives 3D organotypic lymphatic vessel activation in a microfluidic model of the breast tumor microenvironment by Lugo-Cintrón, Karina M, Ayuso, José M, White, Bridget R, Harari, Paul M, Ponik, Suzanne M, Beebe, David J, Gong, Max M, Virumbrales-Muñoz, María

“…Lymphatic vessels (LVs) have been suggested as a preferential conduit for metastatic progression in breast cancer, where a correlation between the occurrence…”
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Social motility of biofilm-like microcolonies in a gliding bacterium by Li, Chao, Hurley, Amanda, Hu, Wei, Warrick, Jay W., Lozano, Gabriel L., Ayuso, Jose M., Pan, Wenxiao, Handelsman, Jo, Beebe, David J.

“…Bacterial biofilms are aggregates of surface-associated cells embedded in an extracellular polysaccharide (EPS) matrix, and are typically stationary. Studies…”
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Evaluating natural killer cell cytotoxicity against solid tumors using a microfluidic model by Ayuso, Jose M., Truttschel, Regan, Gong, Max M., Humayun, Mouhita, Virumbrales-Munoz, Maria, Vitek, Ross, Felder, Mildred, Gillies, Stephen D., Sondel, Paul, Wisinski, Kari B., Patankar, Manish, Beebe, David J., Skala, Melissa C.

“…Immunotherapies against solid tumors face additional challenges compared with hematological cancers. In solid tumors, immune cells and antibodies need to…”
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Glioblastoma on a microfluidic chip: Generating pseudopalisades and enhancing aggressiveness through blood vessel obstruction events by Ayuso, Jose M, Monge, Rosa, Martínez-González, Alicia, Virumbrales-Muñoz, María, Llamazares, Guillermo A, Berganzo, Javier, Hernández-Laín, Aurelio, Santolaria, Jorge, Doblaré, Manuel, Hubert, Christopher, Rich, Jeremy N, Sánchez-Gómez, Pilar, Pérez-García, Víctor M, Ochoa, Ignacio, Fernández, Luis J

“…Glioblastoma (GBM) is one of the most lethal tumor types. Hypercellular regions, named pseudopalisades, are characteristic in these tumors and have been…”
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Advances in Microengineered Platforms for Skin Research by Teertam, Sireesh Kumar, Setaluri, Vijayasaradhi, Ayuso, Jose M.

“…The skin plays a critical role in human physiology, acting both as a barrier to environmental insults and as a window to environmental stimuli. Disruption of…”
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Microfluidic Tumor-on-a-Chip Model to Study Tumor Metabolic Vulnerability by Ayuso, Jose M, Rehman, Shujah, Farooqui, Mehtab, Virumbrales-Muñoz, María, Setaluri, Vijayasaradhi, Skala, Melissa C, Beebe, David J

“…Tumor-specific metabolic adaptations offer an interesting therapeutic opportunity to selectively destroy cancer cells. However, solid tumors also present…”
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Microfluidic Systems to Study Neutrophil Forward and Reverse Migration by Babatunde, Kehinde Adebayo, Ayuso, Jose M, Kerr, Sheena C, Huttenlocher, Anna, Beebe, David J

“…During infection, neutrophils are the most abundantly recruited innate immune cells at sites of infection, playing critical roles in the elimination of local…”
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Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV± cancer by Ayuso, Jose M., Farooqui, Mehtab, Virumbrales-Muñoz, María, Denecke, Katheryn, Rehman, Shujah, Schmitz, Rebecca, Guerrero, Jorge F., Sanchez-de-Diego, Cristina, Campo, Sara Abizanda, Maly, Elizabeth M., Forsberg, Matthew H., Kerr, Sheena C., Striker, Robert, Sherer, Nathan M., Harari, Paul M., Capitini, Christian M., Skala, Melissa C., Beebe, David J.

“…Numerous studies are exploring the use of cell adoptive therapies to treat hematological malignancies as well as solid tumors. However, there are numerous…”
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Author Correction: Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV± cancer by Ayuso, Jose M., Farooqui, Mehtab, Virumbrales-Muñoz, María, Denecke, Katheryn, Rehman, Shujah, Schmitz, Rebecca, Guerrero, Jorge F., Sanchez-de-Diego, Cristina, Campo, Sara Abizanda, Maly, Elizabeth M., Forsberg, Matthew H., Kerr, Sheena C., Striker, Robert, Sherer, Nathan M., Harari, Paul M., Capitini, Christian M., Skala, Melissa C., Beebe, David J.

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Toward improved in vitro models of human cancer by Ayuso, Jose M., Park, Keon-Young, Virumbrales-Muñoz, María, Beebe, David J.

“…Cancer is a leading cause of death across the world and continues to increase in incidence. Despite years of research, multiple tumors (e.g., glioblastoma,…”
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Study of the Chemotactic Response of Multicellular Spheroids in a Microfluidic Device by Ayuso, Jose M, Basheer, Haneen A, Monge, Rosa, Sánchez-Álvarez, Pablo, Doblaré, Manuel, Shnyder, Steven D, Vinader, Victoria, Afarinkia, Kamyar, Fernández, Luis J, Ochoa, Ignacio

“…We report the first application of a microfluidic device to observe chemotactic migration in multicellular spheroids. A microfluidic device was designed…”
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Agarose Spot as a Comparative Method for in situ Analysis of Simultaneous Chemotactic Responses to Multiple Chemokines by Ahmed, Mohaned, Basheer, Haneen A., Ayuso, Jose M., Ahmet, Djevdet, Mazzini, Marco, Patel, Roshan, Shnyder, Steven D., Vinader, Victoria, Afarinkia, Kamyar

“…We describe a novel protocol to quantitatively and simultaneously compare the chemotactic responses of cells towards different chemokines. In this protocol,…”
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Towards Novel Biomimetic In Vitro Models of the Blood-Brain Barrier for Drug Permeability Evaluation by Mármol, Inés, Abizanda-Campo, Sara, Ayuso, Jose M, Ochoa, Ignacio, Oliván, Sara

“…Current available animal and cell-based models for studying brain-related pathologies and drug evaluation face several limitations since they are unable to…”
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