Search Results - "Ayusawa, Dai"

The key role of a basic domain of histone H2B N‐terminal tail in the action of 5‐bromodeoxyuridine to induce cellular senescence by En, Atsuki, Watanabe, Kazuaki, Ayusawa, Dai, Fujii, Michihiko

“…5‐Bromodeoxyuridine (BrdU), a thymidine analogue, is an interesting reagent that modulates various biological phenomena. BrdU, upon incorporation into DNA,…”
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The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP) by En, Atsuki, Takauji, Yuki, Ayusawa, Dai, Fujii, Michihiko

“…Cellular senescence is a phenomenon of irreversible growth arrest of mammalian somatic cells. Senescent cells increase the production of secretory proteins…”
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Restriction of protein synthesis abolishes senescence features at cellular and organismal levels by Takauji, Yuki, Wada, Takumi, Takeda, Asuka, Kudo, Ikuru, Miki, Kensuke, Fujii, Michihiko, Ayusawa, Dai

“…Cellular senescence or its equivalence is induced by treatment of cells with an appropriate inducer of senescence in various cell types. Mild restriction of…”
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Central roles of iron in the regulation of oxidative stress in the yeast Saccharomyces cerevisiae by Matsuo, Ryo, Mizobuchi, Shogo, Nakashima, Maya, Miki, Kensuke, Ayusawa, Dai, Fujii, Michihiko

“…Oxygen is essential for aerobic organisms but causes cytotoxicity probably through the generation of reactive oxygen species (ROS). In this study, we screened…”
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Lamin B receptor plays a key role in cellular senescence induced by inhibition of the proteasome by En, Atsuki, Takauji, Yuki, Miki, Kensuke, Ayusawa, Dai, Fujii, Michihiko

“…Cellular senescence is a terminal growth arrest phenomenon in mammalian cells. Coordinated regulation of protein synthesis and degradation is required to…”
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Combinatorial effects of continuous protein synthesis, ERK-signaling, and reactive oxygen species on induction of cellular senescence by Takauji, Yuki, En, Atsuki, Miki, Kensuke, Ayusawa, Dai, Fujii, Michihiko

“…Mammalian cells, when treated with sub-lethal doses of genotoxic stresses, slow down DNA synthesis but continue protein synthesis. Thus, these cells show an…”
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Aberrant localization of lamin B receptor (LBR) in cellular senescence in human cells by Arai, Rumi, En, Atsuki, Ukekawa, Ryo, Miki, Kensuke, Fujii, Michihiko, Ayusawa, Dai

“…5-Bromodeoxyuridine (BrdU), a thymidine analogue, induces cellular senescence in mammalian cells. BrdU induces cellular senescence probably through the…”
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Triphala, a formulation of traditional Ayurvedic medicine, shows protective effect against X-radiation in HeLa cells by Takauji, Yuki, Miki, Kensuke, Mita, Juma, Hossain, Mohammad Nazir, Yamauchi, Masatake, Kioi, Mitomu, Ayusawa, Dai, Fujii, Michihiko

“…Ayurveda is a holistic medical system of traditional medicine, and Triphala is one of the most popular formulations in Ayurveda. Triphala is composed of three…”
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Molecular basis for premature senescence induced by surfactants in normal human cells by Yamakami, Yoshimi, Miki, Kensuke, Yonekura, Ryuzo, Kudo, Ikuru, Fujii, Michihiko, Ayusawa, Dai

“…Sublethal doses of surfactants as exemplified by NP-40 clearly induce premature senescence in normal human cells. To understand molecular basis for this…”
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ERK1/2 mediates unbalanced growth leading to senescence induced by excess thymidine in human cells by Kobayashi, Yusuke, Lee, Siew Soke, Arai, Rumi, Miki, Kensuke, Fujii, Michihiko, Ayusawa, Dai

“…► Excess thymidine induces unbalanced growth and senescence in normal and tumor cells. ► Knockdown of ERK1 suppressed the above phenomena in normal human…”
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Chyawanprash, a formulation of traditional Ayurvedic medicine, shows a protective effect on skin photoaging in hairless mice by Takauji, Yuki, Morino, Kyoko, Miki, Kensuke, Hossain, Mohammad, Ayusawa, Dai, Fujii, Michihiko

“…OBJECTIVE： Chronic exposure to ultraviolet （UV） radiation induces skin photoaging （premature skin aging）. UV irradiation generates reactive oxygen species…”
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Extract of Emblica officinalis enhances the growth of human keratinocytes in culture by Yamakami, Yoshimi, Morino, Kyoko, Takauji, Yuki, Kasukabe, Ryuichiro, Miki, Kensuke, Hossain, Mohammad Nazir, Ayusawa, Dai, Fujii, Michihiko

“…Keratinocytes are the predominant cell type in the epidermis and play key roles in epidermal function. Thus, identification of the compounds that regulate the…”
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Disruption of a Long-Range Cis-Acting Regulator for Shh Causes Preaxial Polydactyly by Lettice, Laura A., Horikoshi, Taizo, Simon J. H. Heaney, van Baren, Marijke J., van der Linde, Herma C., Breedveld, Guido J., Joosse, Marijke, Akarsu, Nurten, Oostra, Ben A., Endo, Naoto, Shibata, Minoru, Suzuki, Mikio, Takahashi, Eiichi, Shinka, Toshikatsu, Nakahori, Yutaka, Ayusawa, Dai, Nakabayashi, Kazuhiko, Scherer, Stephen W., Heutink, Peter, Hill, Robert E., Noji, Sumihare

“…Preaxial polydactyly (PPD) is a common limb malformation in human. A number of polydactylous mouse mutants indicate that misexpression of Shh is a common…”
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[FeFe]-hydrogenase-like gene is involved in the regulation of sensitivity to oxygen in yeast and nematode by Fujii, Michihiko, Adachi, Noritaka, Shikatani, Kazuki, Ayusawa, Dai

“…Oxygen is essential for the life of aerobic organisms, but reactive oxygen species (ROS) derived from oxygen can be a threat for it. Many genes are involved in…”
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N-terminal short fragment of TUP1 confers resistance to 5-bromodeoxyuridine in the yeast Saccharomyces cerevisiae by Takayama, Shinichi, Fujii, Michihiko, Nakagawa, Yu, Miki, Kensuke, Ayusawa, Dai

“…Small molecules that exhibit biological activity have contributed to the understanding of the molecular mechanisms of various biological phenomena…”
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Nuclear Swelling Occurs during Premature Senescence Mediated by MAP Kinases in Normal Human Fibroblasts by KOBAYASHI, Yusuke, SAKEMURA, Risa, KUMAGAI, Atsuko, SUMIKAWA, Emi, FUJII, Michihiko, AYUSAWA, Dai

“…Excess thymidine induced premature senescence in normal human fibroblasts (TIG-7), with induction of typical senescence markers. Nuclear swelling, as well as…”
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Downregulation of hnRNP C1/C2 by siRNA sensitizes HeLa cells to various stresses by Hossain, Mohammad Nazir, Fuji, Michihiko, Miki, Kensuke, Endoh, Morio, Ayusawa, Dai

“…The heterogeneous nuclear ribonucleoprotein C1/C2 is one of the most abundant proteins in the nucleus, and shown to have roles in cellular differentiation and…”
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Sublethal Doses of Surfactants Induce Premature Senescence in Normal Human Skin Cells by YAMAKAMI, Yoshimi, MIKI, Kensuke, ENDOH, Morio, YONEKURA, Ryuzo, UKEKAWA, Ryo, KOBAYASHI, Yusuke, FUJII, Michihiko, AYUSAWA, Dai

“…We evaluated the cytotoxicity of surfactants in human cells. Synthetic surfactants showed different cytotoxicity levels depending on their structures. The…”
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5-Bromouracil disrupts nucleosome positioning by inducing A-form-like DNA conformation in yeast cells by Miki, Kensuke, Shimizu, Mitsuhiro, Fujii, Michihiko, Hossain, Mohammad Nazir, Ayusawa, Dai

“…5-Bromodeoxyuridine (BrdU) modulates expression of particular genes associated with cellular differentiation and senescence. Our previous studies have…”
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Coordinate expression of the human pregnancy-specific glycoprotein gene family during induced and replicative senescence by Endoh, Morio, Kobayashi, Yusuke, Yamakami, Yoshimi, Yonekura, Ryuzo, Fujii, Michihiko, Ayusawa, Dai

“…Pregnancy-specific glycoproteins (PSGs) comprise a family of highly similar polypeptides encoded by 11 transcriptionally active genes that compactly cluster on…”
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