Investıgatıon of the effects of treatment with enoxaparın sodıum and hyperbarıc oxygen therapy on the recovery of rats wıth achılles tendon rupture

In this study, we aimed to investigate the effects of hyperbaric oxygen therapy and enoxaparin sodium, which are known to accelerate bone tissue healing as well as tendon and soft tissue healing, on the healing of Achilles tendon rupture. Thirty-six rats were used in the present study. All rats were...

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Bibliographic Details
Published in:	BMC musculoskeletal disorders Vol. 25; no. 1; pp. 556 - 8
Main Authors:	Aytekin, Cafer Erman, Turhan, Yalcın, Karaduman, Zekeriya Okan, Arıcan, Mehmet, Saglam, Sönmez, Coskun, Sinem Kantarcıoglu, Uludag, Veysel
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 18-07-2024 BioMed Central BMC
Subjects:	Achilles tendon Achilles Tendon - drug effects Achilles Tendon - injuries Achilles Tendon - pathology Achilles tendon rupture Animals Bone healing Bone surgery Disease Models, Animal Disease prevention Enoxaparin Enoxaparin - pharmacology Enoxaparin - therapeutic use Enoxaparin sodium Fibrosis Hyperbaric oxygen therapy Hyperbaric Oxygenation - methods Inflammation Injuries Investigations Laboratory animals Male Orthopedics Pathology Rat Rats Rats, Sprague-Dawley Rats, Wistar Recovery of Function - drug effects Rupture Sodium Statistical analysis Tendon Injuries - therapy Tendons Thromboembolism Vascularization Wound Healing - drug effects Hyperbaric oxygen therapy Rat Achilles tendon rupture Enoxaparin sodium
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Summary:	In this study, we aimed to investigate the effects of hyperbaric oxygen therapy and enoxaparin sodium, which are known to accelerate bone tissue healing as well as tendon and soft tissue healing, on the healing of Achilles tendon rupture. Thirty-six rats were used in the present study. All rats were divided into groups of nine. The groups were the enoxaparin sodium group, enoxaparin sodium and hyperbaric oxygen group, hyperbaric oxygen group and control group. After 21 days, the process was completed, and the rats were sacrificed. Achilles tendon samples were evaluated histopathologically. The groups were compared according to the results of statistical analysis based on the histopathological data. There was no significant difference between the groups in terms of acute inflammation (p = 0.785) or chronic inflammation (p = 0.827) scores, but there were significant differences in neovascularization (p = 0.009), proliferation (p < 0.001) and fibrosis (p = 0.006) scores. Our study showed that the use of enoxaparin sodium and hyperbaric oxygen had a positive effect on the healing of the Achilles tendon. Based on these results, we believe that the use of enoxaparin sodium and hyperbaric oxygen therapy after Achilles tendon rupture will be beneficial for healing and preventing complications.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1471-2474 1471-2474
DOI:	10.1186/s12891-024-07694-6