In vitro and in vivo MRI imaging and photothermal therapeutic properties of Hematite (α-Fe2O3) Nanorods

Herein we report synthesis of hematite (α-Fe 2 O 3 ) nanorods by calcinating hydrothermally synthesized goethite nanorods at 5000C. The structural, optical and MRI imaging guided cancer therapeutic properties of fabricated nanorods have been discussed in this manscript. FESEM and TEM imaging techniq...

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Bibliographic Details
Published in:	Journal of materials science. Materials in medicine Vol. 33; no. 1; pp. 10 - 13
Main Authors:	Gulzar, Aanisa, Ayoub, Nowsheena, Mir, Jaffar Farooq, Alanazi, Amer M., Shah, M. A., Gulzar, Arif
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-01-2022 Springer Nature B.V Springer
Subjects:	Animals Biocompatibility Biocompatible Materials - chemistry Biomaterials Biomaterials Synthesis and Characterization Biomedical Engineering and Bioengineering Biomedical materials Cell Line Cell Survival Ceramics Chemical compounds Chemistry and Materials Science Composites Contrast agents Contrast media Crystal structure Efficiency Female Ferric Compounds - chemistry Ferric Compounds - toxicity Ferric oxide Glass Goethite HeLa Cells Hematite Humans Imaging Imaging techniques In Vitro Techniques In vivo methods and tests Laboratories Lasers Magnetic Resonance Imaging Magnetism Materials Science Materials Testing Medical imaging Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Nude Microscopy, Electron, Scanning Morphology MRI Nanomaterials Nanorods Nanotubes - chemistry Nanotubes - toxicity Nanotubes - ultrastructure Natural Materials Neoplasms, Experimental - pathology Neoplasms, Experimental - therapy Optical properties PEGylation Pharmacology Phototherapy - methods Photothermal conversion Polyethylene glycol Polyethylene Glycols - chemistry Polymer Sciences PTT R&D Radiation Regenerative Medicine/Tissue Engineering Research & development Spectrum Analysis, Raman Surfaces and Interfaces Thin Films X-Ray Diffraction PTT PEGylation MRI Imaging Nanorods
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Summary:	Herein we report synthesis of hematite (α-Fe 2 O 3 ) nanorods by calcinating hydrothermally synthesized goethite nanorods at 5000C. The structural, optical and MRI imaging guided cancer therapeutic properties of fabricated nanorods have been discussed in this manscript. FESEM and TEM imaging techniques were used to confirm the nanorod like morphology of as prepared materials. As we know that Fe 2 O 3 nanorods with size in the range of 25–30 nm exhibit super magnetism. After coating with the PEG, the as prepared nanorods can be used as T 2 MR imaging contrast agents. An excellent T 2 MRI contrast of 38.763 mM –1 s –1 achieved which is highest reported so far for α-Fe 2 O 3 . Besides the as prepared nanorods display an excellent photothermal conversion efficiency of 39.5% thus acts as an excellent photothermal therapeutic agent. Thus, we envision the idea of testing our nanorods for photothermal therapy and MR imaging application both in vitro and in vivo, achieving an excellent T 2 MRI contrast and photothermal therapy effect with as prepared PEGylated nanorods.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0957-4530 1573-4838 1573-4838
DOI:	10.1007/s10856-021-06636-1