Search Results - "Ayoub, Iyad M"

Sodium-Hydrogen Exchanger Isoform-1 Inhibition: A Promising Pharmacological Intervention for Resuscitation from Cardiac Arrest by Gazmuri, Raúl J, Radhakrishnan, Jeejabai, Ayoub, Iyad M

“…Out-of-hospital sudden cardiac arrest is a major public health problem with an overall survival of less than 5%. Upon cardiac arrest, cessation of coronary…”
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Targeting mitochondria for resuscitation from cardiac arrest by AYOUB, Iyad M, RADHAKRISHNAN, Jeejabai, GAZMURI, Raul J

“…Reversal of cardiac arrest requires reestablishment of aerobic metabolism by reperfusion with oxygenated blood of tissues that have been ischemic for variable…”
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Clinically plausible hyperventilation does not exert adverse hemodynamic effects during CPR but markedly reduces end-tidal PCO2 by Gazmuri, Raúl J, Ayoub, Iyad M, Radhakrishnan, Jeejabai, Motl, Jill, Upadhyaya, Madhav P

“…Abstract Aims Ventilation at high respiratory rates is considered detrimental during CPR because it may increase intrathoracic pressure limiting venous return…”
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In vivo opening of the mitochondrial permeability transition pore in a rat model of ventricular fibrillation and closed-chest resuscitation by Ayoub, Iyad M, Radhakrishnan, Jeejabai, Gazmuri, Raúl J

“…Opening of the mitochondrial permeability transition pore (mPTP) is considered central to reperfusion injury. Yet, most of our knowledge comes from…”
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Circulating levels of cytochrome c after resuscitation from cardiac arrest: a marker of mitochondrial injury and predictor of survival by Radhakrishnan, Jeejabai, Wang, Sufen, Ayoub, Iyad M, Kolarova, Julieta D, Levine, Rita F, Gazmuri, Raúl J

“…Ca(2+) overload and reactive oxygen species can injure mitochondria during ischemia and reperfusion. We hypothesized that mitochondrial injury occurs during…”
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Myocardial protection during ventricular fibrillation by inhibition of the sodium-hydrogen exchanger isoform-1 by Gazmuri, Raúl J, Ayoub, Iyad M, Kolarova, Julieta D, Karmazyn, Morris

“…Activation of the sarcolemmal sodium-hydrogen exchanger isoform-1 (NHE-1) in response to the intense intracellular acidosis that develops during ischemia has…”
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Cariporide given during resuscitation promotes return of electrically stable and mechanically competent cardiac activity by Ayoub, Iyad M, Kolarova, Julieta, Gazmuri, Raúl J

“…Abstract Episodes of ventricular fibrillation (VF) and myocardial dysfunction commonly occur after cardiac resuscitation compromising the return of stable…”
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Vitamin C compromises cardiac resuscitability in a rat model of ventricular fibrillation by Motl, Jill, Radhakrishnan, Jeejabai, Ayoub, Iyad M, Grmec, Stefek, Gazmuri, Raúl J

“…Resuscitation from cardiac arrest is partly limited by progressive reduction in left ventricular distensibility, leading to decreased hemodynamic efficacy of…”
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Limiting sarcolemmal Na+ entry during resuscitation from ventricular fibrillation prevents excess mitochondrial Ca2+ accumulation and attenuates myocardial injury by Wang, Sufen, Radhakrishnan, Jeejabai, Ayoub, Iyad M, Kolarova, Julieta D, Taglieri, Domenico M, Gazmuri, Raul J

“…Department of Medicine, Division of Critical Care Medicine, and Department of Physiology and Biophysics, Rosalind Franklin University of Medicine and Science;…”
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Zoniporide preserves left ventricular compliance during ventricular fibrillation and minimizes postresuscitation myocardial dysfunction through benefits on energy metabolism by Ayoub, Iyad M, Kolarova, Julieta D, Kantola, Ronald L, Radhakrishnan, Jeejabai, Wang, Sufen, Gazmuri, Raúl J

“…OBJECTIVE:To investigate whether sodium-hydrogen exchanger isoform-1 (NHE-1) inhibition attenuates myocardial injury during resuscitation from ventricular…”
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Reply to Letter to the Editor by Faybik, Peter MD, Lahner, Daniel MD, and Schramm, Wolfgang MD entitled “An outlasting error of Ernest Henry Starling for at least 83 years in the medical literature” by Gazmuri, Raúl J, Ayoub, Iyad M

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AVE4454B—a novel sodium-hydrogen exchanger isoform-1 inhibitor—compared less effective than cariporide for resuscitation from cardiac arrest by Radhakrishnan, Jeejabai, Kolarova, Julieta D, Ayoub, Iyad M, Gazmuri, Raúl J

“…We compared the efficacy of the novel sodium-hydrogen exchanger (NHE-1) inhibitor AVE4454B with cariporide for resuscitation from ventricular fibrillation (VF)…”
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Activation of caspase-3 may not contribute to postresuscitation myocardial dysfunction by Radhakrishnan, Jeejabai, Ayoub, Iyad M, Gazmuri, Raúl J

“…We have previously reported that postresuscitation myocardial dysfunction is accompanied by the release of cytochrome c and caspase-3 activation. We now…”
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Optimal timing for electrical defibrillation after prolonged untreated ventricular fibrillation by Kolarova, Julieta, Ayoub, Iyad M, Yi, Zhong, Gazmuri, Raúl J

“…OBJECTIVEIt currently is recommended that electrical shocks be delivered immediately on recognition of ventricular fibrillation. However, decreased…”
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Erythropoietin facilitates resuscitation from ventricular fibrillation by signaling protection of mitochondrial bioenergetic function in rats by Radhakrishnan, Jeejabai, Upadhyaya, Madhav P, Ng, Matthew, Edelheit, Ari, Moy, Hawnyeu M, Ayoub, Iyad M, Gazmuri, Raúl J

“…We previously reported beneficial myocardial effects during chest compression after administration of high-dose erythropoietin. We hypothesized that…”
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Cariporide enables hemodynamically more effective chest compression by leftward shift of its flow-depth relationship by Kolarova, Julieta D, Ayoub, Iyad M, Gazmuri, Raúl J

“…When given during closed-chest resuscitation, cariporide (4-isopropyl-methylsulfonylbenzoyl-guanidine methanesulfonate; a selective inhibitor of the Na(+)/H(+)…”
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Sodium-hydrogen exchange inhibition during ventricular fibrillation: Beneficial effects on ischemic contracture, action potential duration, reperfusion arrhythmias, myocardial function, and resuscitability by AYOUB, Iyad M, KOLAROVA, Julieta, ZHONG YI, TREVEDI, Atul, DESHMUKH, Hanumant, LUBELL, David L, FRANZ, Michael R, MALDONADO, Frank A, GAZMURI, Raul J

“…Inhibition of the sarcolemmal sodium-hydrogen exchanger isoform-1 (NHE-1) is emerging as a promising novel strategy for ameliorating myocardial injury…”
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Cariporide minimizes adverse myocardial effects of epinephrine during resuscitation from ventricular fibrillation by Ayoub, Iyad M, Kolarova, Julieta, Kantola, Ronald L, Sanders, Robert, Gazmuri, Raúl J

“…OBJECTIVE:Epinephrine given during closed-chest resuscitation increases blood flow across the coronary and cerebral circuits. However, epinephrine worsens…”
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The Case for Sodium-Hydrogen Exchanger Isoform-1 Inhibition During Cardiac Resuscitation Remains Strong by Gazmuri, Raúl J, Ayoub, Iyad M

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CO2: Friend or foe? by Gazmuri, Raúl J, Bhuriya, Rohitkumar, Ayoub, Iyad M

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