Search Results - "Ayon, Ramon"

PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension by Cao, Yapeng, Zhang, Xiaoyu, Wang, Lina, Yang, Qiuhua, Ma, Qian, Xu, Jiean, Wang, Jingjing, Kovacs, Laszlo, Ayon, Ramon J., Liu, Zhiping, Zhang, Min, Zhou, Yaqi, Zeng, Xianqiu, Xu, Yiming, Wang, Yong, Fulton, David J., Weintraub, Neal L., Lucas, Rudolf, Dong, Zheng, Yuan, Jason X.-J., Sullivan, Jennifer C., Meadows, Louise, Barman, Scott A., Wu, Chaodong, Quan, Junmin, Hong, Mei, Su, Yunchao, Huo, Yuqing

“…Increased glycolysis in the lung vasculature has been connected to the development of pulmonary hypertension (PH). We therefore investigated whether glycolytic…”
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Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition by Tang, Haiyang, Babicheva, Aleksandra, McDermott, Kimberly M, Gu, Yali, Ayon, Ramon J, Song, Shanshan, Wang, Ziyi, Gupta, Akash, Zhou, Tong, Sun, Xutong, Dash, Swetaleena, Wang, Zilu, Balistrieri, Angela, Zheng, Qiuyu, Cordery, Arlette G, Desai, Ankit A, Rischard, Franz, Khalpey, Zain, Wang, Jian, Black, Stephen M, Garcia, Joe G N, Makino, Ayako, Yuan, Jason X-J

“…Pulmonary vascular remodeling characterized by concentric wall thickening and intraluminal obliteration is a major contributor to the elevated pulmonary…”
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STIM2 (Stromal Interaction Molecule 2)–Mediated Increase in Resting Cytosolic Free Ca2+ Concentration Stimulates PASMC Proliferation in Pulmonary Arterial Hypertension by Song, Shanshan, Carr, Shane G, McDermott, Kimberly M, Rodriguez, Marisela, Babicheva, Aleksandra, Balistrieri, Angela, Ayon, Ramon J, Wang, Jian, Makino, Ayako, Yuan, Jason X.-J

“…An increase in cytosolic free Ca concentration ([Ca]cyt) in pulmonary artery smooth muscle cells (PASMCs) triggers pulmonary vasoconstriction and stimulates…”
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Editorial: Calcium regulation and Mechano-transduction in vascular diseases: obligatory role of transient receptor potential and Piezo channels by Ayon, Ramon J, Kuppusamy, Maniselvan, Ceolotto, Giulio, Chen, Yen-Lin

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Revisiting the Role of KCNA5 in Pulmonary Arterial Hypertension by Ayon, Ramon J, Yuan, Jason X-J

“…Ayon and Yuan discuss the study by A. Vera-Zambrano and colleagues on nonsynonymous SNPs of KCNA5 found in patients with pulmonary arterial hypertension (PAH)…”
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Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension by Wang, Ziyi, Chen, Jiyuan, Babicheva, Aleksandra, Jain, Pritesh P, Rodriguez, Marisela, Ayon, Ramon J, Ravellette, Keeley S, Wu, Linda, Balistrieri, Francesca, Tang, Haiyang, Wu, Xiaomin, Zhao, Tengteng, Black, Stephen M, Desai, Ankit A, Garcia, Joe G N, Sun, Xin, Shyy, John Y-J, Valdez-Jasso, Daniela, Thistlethwaite, Patricia A, Makino, Ayako, Wang, Jian, Yuan, Jason X-J

“…Piezo is a mechanosensitive cation channel responsible for stretch-mediated Ca and Na influx in multiple types of cells. Little is known about the functional…”
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Divergent changes of p53 in pulmonary arterial endothelial and smooth muscle cells involved in the development of pulmonary hypertension by Wang, Ziyi, Yang, Kai, Zheng, Qiuyu, Zhang, Chenting, Tang, Haiyang, Babicheva, Aleksandra, Jiang, Qian, Li, Meichan, Chen, Yuqin, Carr, Shane G, Wu, Kang, Zhang, Qian, Balistrieri, Angela, Wang, Christina, Song, Shanshan, Ayon, Ramon J, Desai, Ankit A, Black, Stephen M, Garcia, Joe G N, Makino, Ayako, Yuan, Jason X-J, Lu, Wenju, Wang, Jian

“…The tumor-suppressive role of p53, a transcription factor that regulates the expression of many genes, has been linked to cell cycle arrest, apoptosis, and…”
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Pathogenic role of calcium-sensing receptors in the development and progression of pulmonary hypertension by Tang, Haiyang, Yamamura, Aya, Yamamura, Hisao, Song, Shanshan, Fraidenburg, Dustin R, Chen, Jiwang, Gu, Yali, Pohl, Nicole M, Zhou, Tong, Jiménez-Pérez, Laura, Ayon, Ramon J, Desai, Ankit A, Goltzman, David, Rischard, Franz, Khalpey, Zain, Black, Stephan M, Garcia, Joe G N, Makino, Ayako, Yuan, Jason X J

“…An increase in cytosolic free Ca(2+) concentration ([Ca(2+)]cyt) in pulmonary arterial smooth muscle cells (PASMC) is a major trigger for pulmonary…”
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MicroRNA-mediated downregulation of K + channels in pulmonary arterial hypertension by Babicheva, Aleksandra, Ayon, Ramon J, Zhao, Tengteng, Ek Vitorin, Jose F, Pohl, Nicole M, Yamamura, Aya, Yamamura, Hisao, Quinton, Brooke A, Ba, Manqing, Wu, Linda, Ravellette, Keeley S, Rahimi, Shamin, Balistrieri, Francesca, Harrington, Angela, Vanderpool, Rebecca R, Thistlethwaite, Patricia A, Makino, Ayako, Yuan, Jason X-J

“…Downregulated expression of K channels and decreased K currents in pulmonary artery smooth muscle cells (PASMC) have been implicated in the development of…”
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Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia‐induced pulmonary hypertension by Wu, Kang, Zhang, Qian, Wu, Xiongting, Lu, Wenju, Tang, Haiyang, Liang, Zhihao, Gu, Yali, Song, Shanshan, Ayon, Ramon J, Wang, Ziyi, McDermott, Kimberly M, Balistrieri, Angela, Wang, Christina, Black, Stephen M, Garcia, Joe G N, Makino, Ayako, Yuan, Jason X‐J, Wang, Jian

“…Background and Purpose Sustained pulmonary vasoconstriction and excessive pulmonary vascular remodelling are two major causes of elevated pulmonary vascular…”
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p90RSK2, a new MLCK mediates contractility in myosin light chain kinase null smooth muscle by Kalra, Jaspreet, Artamonov, Mykhaylo, Wang, Hua, Franke, Aaron, Markowska, Zaneta, Jin, Li, Derewenda, Zygmunt S, Ayon, Ramon J, Somlyo, Avril

“…Phosphorylation of smooth muscle (SM) myosin regulatory light chain (RLC ) is a critical switch leading to SM contraction. The canonical view held that only…”
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Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension by Tang, Haiyang, PhD, Wu, Kang, MD, PhD, Wang, Jian, MD, Vinjamuri, Sujana, MD, MS, Gu, Yali, MS, RN, Song, Shanshan, MD, PhD, Wang, Ziyi, MD, Zhang, Qian, MD, Balistrieri, Angela, Ayon, Ramon J., PhD, Rischard, Franz, MD, Vanderpool, Rebecca, PhD, Chen, Jiwang, PhD, Zhou, Guofei, PhD, Desai, Ankit A., MD, Black, Stephen M., PhD, Garcia, Joe G.N., MD, Yuan, Jason X.-J., MD, PhD, Makino, Ayako, PhD

“…Visual Abstract…”
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Endothelial dysfunction in pulmonary arterial hypertension: an evolving landscape (2017 Grover Conference Series) by Ranchoux, Benoît, Harvey, Lloyd D., Ayon, Ramon J., Babicheva, Aleksandra, Bonnet, Sebastien, Chan, Stephen Y., Yuan, Jason X.-J., Perez, Vinicio de Jesus

“…Endothelial dysfunction is a major player in the development and progression of vascular pathology in pulmonary arterial hypertension (PAH), a disease…”
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Calcium-Sensing Receptor Regulates Cytosolic [Ca 2+ ] and Plays a Major Role in the Development of Pulmonary Hypertension by Smith, Kimberly A, Ayon, Ramon J, Tang, Haiyang, Makino, Ayako, Yuan, Jason X-J

“…Pulmonary arterial hypertension (PAH) is a progressive disease characterized by elevated pulmonary vascular resistance (PVR) leading to right heart failure and…”
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Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension by Forrest, Abigail S, Joyce, Talia C, Huebner, Marissa L, Ayon, Ramon J, Wiwchar, Michael, Joyce, John, Freitas, Natalie, Davis, Alison J, Ye, Linda, Duan, Dayue D, Singer, Cherie A, Valencik, Maria L, Greenwood, Iain A, Leblanc, Normand

“…Pulmonary artery smooth muscle cells (PASMCs) are more depolarized and display higher Ca(2+) levels in pulmonary hypertension (PH). Whether the functional…”
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Flow shear stress enhances intracellular Ca2+ signaling in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension by Song, Shanshan, Yamamura, Aya, Yamamura, Hisao, Ayon, Ramon J, Smith, Kimberly A, Tang, Haiyang, Makino, Ayako, Yuan, Jason X-J

“…An increase in cytosolic Ca(2+) concentration ([Ca(2+)]cyt) in pulmonary arterial smooth muscle cells (PASMC) is a major trigger for pulmonary vasoconstriction…”
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Molecular mechanism of TMEM16A regulation: role of CaMKII and PP1/PP2A by Ayon, Ramon J, Hawn, Matthew B, Aoun, Joydeep, Wiwchar, Michael, Forrest, Abigail S, Cunningham, Fiona, Singer, Cherie A, Valencik, Maria L, Greenwood, Iain A, Leblanc, Normand

“…This study explored the mechanism by which Ca -activated Cl channels (CaCCs) encoded by the gene are regulated by calmodulin-dependent protein kinase II…”
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Ryanodine receptor-2: a necessity for gating store-operated Ca2+ channels by Song, Shanshan, Ayon, Ramon J, Yuan, Jason X-J

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Notch enhances Ca 2+ entry by activating calcium-sensing receptors and inhibiting voltage-gated K + channels by Song, Shanshan, Babicheva, Aleksandra, Zhao, Tengteng, Ayon, Ramon J, Rodriguez, Marisela, Rahimi, Shamin, Balistrieri, Francesca, Harrington, Angela, Shyy, John Y-J, Thistlethwaite, Patricia A, Makino, Ayako, Yuan, Jason X-J

“…The increase in cytosolic Ca concentration ([Ca ] ) and upregulation of calcium-sensing receptor (CaSR) and stromal interaction molecule 2 (STIM2) along with…”
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New insights into the pathology of pulmonary hypertension: implication of the miR‐210/ISCU1/2/Fe‐S axis by Tang, Haiyang, Ayon, Ramon J, Yuan, Jason X‐J

“…Elevated pulmonary arterial pressure in patients with pulmonary hypertension (PH) is mainly caused by increased pulmonary vascular resistance (PVR), due…”
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