Search Results - "Aymami, Juan"
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Solid-phase synthesis of oligomers carrying several chromophore units linked by phosphodiester backbones
Published in Bioorganic & medicinal chemistry letters (01-04-2008)“…The synthesis of oligomers having several DNA-intercalating units linked by phosphodiester bonds is reported. A method for the preparation of oligomers by…”
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Design, synthesis and antiproliferative properties of oligomers with chromophore units linked by amide backbones
Published in Bioorganic & medicinal chemistry (01-04-2008)“…The synthesis of oligomers having several chromophore units linked by amide bonds is reported. The preparation of oligomers made up of several chromophore…”
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Molecular structure of the netropsin-d(CGCGATATCGCG) complex: DNA conformation in an alternating AT segment
Published in Biochemistry (Easton) (10-01-1989)“…The molecular structure of the complex between a minor groove binding drug (netropsin) and the DNA dodecamer d(CGCGATATCGCG) has been solved and refined by…”
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The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites
Published in Nature structural biology (01-01-2002)“…Cryptolepine, a naturally occurring indoloquinoline alkaloid used as an antimalarial drug in Central and Western Africa, has been found to bind to DNA in a…”
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Pharmacological chaperones for enzyme enhancement therapy in genetic diseases
Published in Pharmaceutical patent analyst (01-01-2013)“…Pharmacological chaperone therapy (PCT) is a rather new approach consisting in targeting incorrectly folded proteins by small molecules, thus, facilitating the…”
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Micro-molding with ultrasonic vibration energy: New method to disperse nanoclays in polymer matrices
Published in Ultrasonics sonochemistry (01-07-2014)“…•Ultrasonic micro-molding is effective in preparing nanocomposites from natural and organo-modified montmorillonites.•Ultrasonic energy renders exfoliated…”
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Intercalative DNA binding of the marine anticancer drug variolin B
Published in Scientific reports (04-01-2017)“…Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor,…”
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DNA minor groove recognition of a non-self-complementary AT-rich sequence by a tris-benzimidazole ligand
Published in Nucleic acids research (01-07-1999)“…The crystal structure of the non-self-complementary dodecamer DNA duplex formed by d(CG[5BrC]ATAT-TTGCG) and d(CGCAAATATGCG) has been solved to 2.3 Å…”
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Preparation of micro-molded exfoliated clay nanocomposites by means of ultrasonic technology
Published in Journal of polymer research (01-11-2014)“…Ultrasound micro-molding technology has been tested as a new method to get polymer/clay nanocomposites. Biodegradable polylactide (PLA) and poly…”
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Molecular Structure of Nicked DNA: A Substrate for DNA Repair Enzymes
Published in Proceedings of the National Academy of Sciences - PNAS (01-04-1990)“…The molecular structure of a nicked dodecamer DNA double helix, made of a ternary system containing d(CGCGAAAACGCG) + d(CGCGTT) + d(TTCGCG) oligonucleotides,…”
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Effects of 5-fluorouracil/guanine wobble base pairs in Z-DNA: molecular and crystal structure of d(CGCGFG)
Published in Nucleic acids research (11-02-1989)“…The chemotherapeutic agent 5-fluorouracil is a DNA base analogue which is known to incorporate into DNA in vivo. We have solved the structure of the…”
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