Search Results - "Aylwin, Simon"

Pronounced response of papillary craniopharyngioma to treatment with vemurafenib, a BRAF inhibitor by Aylwin, Simon J. B., Bodi, Istvan, Beaney, Ronald

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Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters by LE ROUX, Carel W, AYLWIN, Simon J. B, BATTERHAM, Rachel L, BORG, Cynthia M, COYLE, Frances, PRASAD, Vyas, SHUREY, Sandra, GHATEI, Mohammad A, PATEL, Ameet G, BLOOM, Stephen R

“…To study the effect of bariatric surgery on the entero-hypothalamic endocrine axis of humans and rodents. Bariatric surgery is the most effective obesity…”
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Gut Hypertrophy After Gastric Bypass Is Associated With Increased Glucagon-Like Peptide 2 and Intestinal Crypt Cell Proliferation by LE ROUX, Carel W, BORG, Cynthia, WALLIS, Katharina, VINCENT, Royce P, BUETER, Marco, GOODLAD, Robert, GHATEI, Mohammed A, PATEL, Ameet, BLOOM, Stephen R, AYLWIN, Simon J. B

“…We aimed to determine changes in crypt cell proliferation and glucagon-like peptide-2 (GLP-2) in rodents and man after Roux-en-Y gastric bypass (RYGB)…”
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Targeted treatment of papillary craniopharyngiomas harboring BRAF V600E mutations by Juratli, Tareq A., Jones, Pamela S., Wang, Nancy, Subramanian, Megha, Aylwin, Simon J. B., Odia, Yazmin, Rostami, Elham, Gudjonsson, Olafur, Shaw, Brian L., Cahill, Daniel P., Galanis, Evanthia, Barker, Fred G., Santagata, Sandro, Brastianos, Priscilla K.

“…Papillary craniopharyngiomas (PCPs) are characterized by the presence of BRAF V600E mutations, which are emerging as a useful guide for diagnosis and treatment…”
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Identification of an optimal prolactin threshold to determine prolactinoma size using receiver operating characteristic analysis by Leca, Bianca M., Mytilinaiou, Maria, Tsoli, Marina, Epure, Andreea, Aylwin, Simon J. B., Kaltsas, Gregory, Randeva, Harpal S., Dimitriadis, Georgios K.

“…Prolactinomas represent the most common type of secretory pituitary neoplasms, with a therapeutic management that varies considerably based on tumour size and…”
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Diagnosis and management of parathyroid carcinoma: a state of the art review by Roser, Pia, Leca, Bianca M, Coelho, Claudia, Schulte, Klaus-Martin, Gilbert, Jackie, Drakou, Eftychia E, Kosmas, Christos, Chuah, Ling Ling, Wassati, Husam, Miras, Alexander D., Crane, James, Aylwin, Simon J B, Grossman, Ashley B., Dimitriadis, Georgios K.

“…Parathyroid carcinoma is one of the least common endocrine malignancies, and accounts for approximately 1% of all patients with primary hyperparathyroidism. A…”
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Laparoscopic Adjustable Gastric Banding—Should a Second Chance Be Given? by Leca, Bianca M., Khan, Uzma, Abraham, Jenny, Halder, Louise, Shuttlewood, Emma, Shah, Neha, Ellis, Hugh L., Aylwin, Simon J. B., Barber, Thomas M., Menon, Vinod, Randeva, Harpal S., Dimitriadis, Georgios K.

“…Background Obesity is a chronic relapsing-remitting disease and a global pandemic, being associated with multiple comorbidities. Laparoscopic adjustable…”
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Prolactinoma in childhood and adolescence—Tumour size at presentation predicts management strategy: Single centre series and a systematic review and meta‐analysis by Arya, Ved Bhushan, Aylwin, Simon J. B., Hulse, Tony, Ajzensztejn, Michal, Kalitsi, Jennifer, Kalogirou, Nicolas, Bodi, Istvan, Thomas, Nick, Hampton, Tim, Kapoor, Ritika R., Buchanan, Charles R.

“…Objective To report the clinical presentation, management and outcomes of young patients with prolactinomas (<20 years) and conduct a systematic review and…”
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The efficacy of GLP‐1RAs for the management of postprandial hypoglycemia following bariatric surgery: a systematic review by Llewellyn, David C., Logan Ellis, Hugh, Aylwin, Simon J. B., Oštarijaš, Eduard, Green, Shauna, Sheridan, William, Chew, Nicholas W. S., Roux, Carel W., Miras, Alexander D., Patel, Ameet G., Vincent, Royce P., Dimitriadis, Georgios K.

“…Objective Postprandial hyperinsulinemic hypoglycemia with neuroglycopenia is an increasingly recognized complication of Roux‐en‐Y gastric bypass and gastric…”
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A 13-Steroid Serum Panel Based on LC-MS/MS: Use in Detection of Adrenocortical Carcinoma by Taylor, David R, Ghataore, Lea, Couchman, Lewis, Vincent, Royce P, Whitelaw, Ben, Lewis, Dylan, Diaz-Cano, Salvador, Galata, Gabriele, Schulte, Klaus-Martin, Aylwin, Simon, Taylor, Norman F

“…Adrenocortical carcinoma (ACC) is a rare malignancy, with an annual incidence of 1 or 2 cases per million. Biochemical diagnosis is challenging because up to…”
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COVID-19 diagnoses in South East London peaked before the UK suggesting early measures reduced transmission by Aylwin, Simon J.B., Patel, Amit S., Post, Frank A.

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Ectopic hyperprolactinaemia due to a malignant uterine tumor resembling ovarian sex cord tumors (UTROCST) by Dimitriadis, Georgios K., Wajman, Delane S., Bidmead, John, Diaz-Cano, Salvador J., Arshad, Sobia, Bakhit, Mohamed, Lewis, Dylan, Aylwin, Simon J. B.

“…Purpose Moderate hyperprolactinaemia (2–5 times upper limit of normal) occurring in a patient with a normal pituitary MRI is generally considered to be due to…”
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Effectiveness of Metyrapone in Treating Cushing's Syndrome: A Retrospective Multicenter Study in 195 Patients by Daniel, Eleni, Aylwin, Simon, Mustafa, Omar, Ball, Steve, Munir, Atif, Boelaert, Kristien, Chortis, Vasileios, Cuthbertson, Daniel J, Daousi, Christina, Rajeev, Surya P, Davis, Julian, Cheer, Kelly, Drake, William, Gunganah, Kirun, Grossman, Ashley, Gurnell, Mark, Powlson, Andrew S, Karavitaki, Niki, Huguet, Isabel, Kearney, Tara, Mohit, Kumar, Meeran, Karim, Hill, Neil, Rees, Aled, Lansdown, Andrew J, Trainer, Peter J, Minder, Anna-Elisabeth H, Newell-Price, John

“…Background: Cushing's syndrome (CS) is a severe condition with excess mortality and significant morbidity necessitating control of hypercortisolemia. There are…”
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A randomised, open-label, parallel group phase 2 study of antisense oligonucleotide therapy in acromegaly by Trainer, Peter J, Newell-Price, John D C, Ayuk, John, Aylwin, Simon J B, Rees, Aled, Drake, William, Chanson, Philippe, Brue, Thierry, Webb, Susan M, Fajardo, Carmen, Aller, Javier, McCormack, Ann I, Torpy, David J, Tachas, George, Atley, Lynne, Ryder, David, Bidlingmaier, Martin

“…Objective ATL1103 is a second-generation antisense oligomer targeting the human growth hormone (GH) receptor. This phase 2 randomised, open-label,…”
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Tyrosine kinase inhibitor sunitinib allows insulin independence in long-standing type 1 diabetes by Huda, Mohammed S B, Amiel, Stephanie A, Ross, Paul, Aylwin, Simon J B

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A Comparison of the Blood Glucose, Growth Hormone, and Cortisol Responses to Two Doses of Insulin (0.15 U/kg vs. 0.10 U/kg) in the Insulin Tolerance Test: A Single-Centre Audit of 174 Cases by Yeoh, Phillip, Dwyer, Andrew A., Anghel, Ella, Bouloux, Pierre M., Khoo, Bernard, Chew, Shern, Wernig, Florian, Carroll, Paul, Aylwin, Simon J. B., Baldeweg, Stephanie E., Drake, William, Todd, Jeannie, Mangena, Lindiwe, Grossman, Ashley

“…Objective. The insulin tolerance test (ITT) is the gold standard endocrine test used to assess the integrity of the growth hormone (GH) and cortisol axes. The…”
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Pituitary apoplexy in an adolescent male with macroprolactinoma presenting as middle cerebral artery territory infarction by Agrawal, Pankaj, Newbold, Sally, Busaidi, Ayisha Al, Kapoor, Ritika R, Thomas, Nick, Aylwin, Simon Jb, Buchanan, Charles R, Arya, Ved Bhushan

“…Pituitary apoplexy typically presents with acute headache, vomiting, visual disturbance, and confusion. Herein, we report a rare presentation of ischemic…”
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GLP-1 and Glucagon Secretion from a Pancreatic Neuroendocrine Tumor Causing Diabetes and Hyperinsulinemic Hypoglycemia by Roberts, Rachel E, Zhao, Min, Whitelaw, Ben C, Ramage, John, Diaz-Cano, Salvador, le Roux, Carel W, Quaglia, Alberto, Huang, Guo Cai, Aylwin, Simon J. B

“…Context: Glucagon-like peptide-1 (GLP-1) is a gut peptide that promotes insulin release from pancreatic β-cells and stimulates β-cell hyperplasia. GLP-1…”
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Lesion-based indicators predict long-term outcomes of pheochromocytoma and paraganglioma– SIZEPASS by Hanschell, Helena, Diaz-Cano, Salvador, Blanes, Alfredo, Talat, Nadia, Galatá, Gabriele, Aylwin, Simon, Schulte, Klaus Martin

“…Aim We seek a simple and reliable tool to predict malignant behavior of pheochromocytoma and paraganglioma (PPGL). Methods This single-center prospective…”
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The impact of mitotane therapy on serum-free proteins in patients with adrenocortical carcinoma by Lech, Magdalena, Ranasinghe, Ruvini, Vincent, Royce P, Taylor, David R, Ghataore, Lea, Luxton, James, Lajeunesse-Trempe, Fannie, Roser, Pia, Drakou, Eftychia E, Chuah, Ling Ling, Grossman, Ashley B, Aylwin, Simon J B, Dimitriadis, Georgios K

“…Adrenocortical carcinoma (ACC) is a rare malignancy of the adrenal cortex. Whilst surgery is the preferred treatment, adjunctive therapy with mitotane may be…”
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