Search Results - "Aylwin, Carlos F"

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  1. 1

    Trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty by Toro, Carlos A., Wright, Hollis, Aylwin, Carlos F., Ojeda, Sergio R., Lomniczi, Alejandro

    Published in Nature communications (04-01-2018)
    “…Polycomb group (PcG) proteins control the timing of puberty by repressing the Kiss1 gene in hypothalamic arcuate nucleus (ARC) neurons. Here we identify two…”
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    Journal Article
  2. 2

    MKRN3 inhibits the reproductive axis through actions in kisspeptin-expressing neurons by Abreu, Ana Paula, Toro, Carlos A, Song, Yong Bhum, Navarro, Victor M, Bosch, Martha A, Eren, Aysegul, Liang, Joy N, Carroll, Rona S, Latronico, Ana Claudia, Rønnekleiv, Oline K, Aylwin, Carlos F, Lomniczi, Alejandro, Ojeda, Sergio, Kaiser, Ursula B

    Published in The Journal of clinical investigation (01-08-2020)
    “…The identification of loss-of-function mutations in MKRN3 in patients with central precocious puberty in association with the decrease in MKRN3 expression in…”
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  3. 3

    Polycomb represses a gene network controlling puberty via modulation of histone demethylase Kdm6b expression by Wright, Hollis, Aylwin, Carlos F., Toro, Carlos A., Ojeda, Sergio R., Lomniczi, Alejandro

    Published in Scientific reports (21-01-2021)
    “…Female puberty is subject to Polycomb Group (PcG)-dependent transcriptional repression. Kiss1 , a puberty-activating gene, is a key target of this silencing…”
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  4. 4

    Sex-specific pubertal and metabolic regulation of Kiss1 neurons via Nhlh2 by Leon, Silvia, Talbi, Rajae, McCarthy, Elizabeth A, Ferrari, Kaitlin, Fergani, Chrysanthi, Naule, Lydie, Choi, Ji Hae, Carroll, Rona S, Kaiser, Ursula B, Aylwin, Carlos F, Lomniczi, Alejandro, Navarro, Víctor M

    Published in eLife (08-09-2021)
    “…Hypothalamic Kiss1 neurons control gonadotropin-releasing hormone release through the secretion of kisspeptin. Kiss1 neurons serve as a nodal center that…”
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    Characterization of SALL2 Gene Isoforms and Targets Across Cell Types Reveals Highly Conserved Networks by Farkas, Carlos, Quiroz, Aracelly, Alvarez, Claudia, Hermosilla, Viviana, Aylwin, Carlos F, Lomniczi, Alejandro, Castro, Ariel F, Hepp, Matias I, Pincheira, Roxana

    Published in Frontiers in genetics (22-02-2021)
    “…The SALL2 transcription factor, an evolutionarily conserved gene through vertebrates, is involved in normal development and neuronal differentiation. In…”
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  7. 7

    Emerging Genetic and Epigenetic Mechanisms Underlying Pubertal Maturation in Adolescence by Aylwin, Carlos F., Toro, Carlos A., Shirtcliff, Elizabeth, Lomniczi, Alejandro

    Published in Journal of research on adolescence (01-03-2019)
    “…The adolescent transition begins with the onset of puberty which, upstream in the brain, is initiated by the gonadotropin‐releasing hormone (GnRH) pulse…”
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    Sirtuin (SIRT)-1: At the crossroads of puberty and metabolism by Aylwin, Carlos F., Lomniczi, Alejandro

    “…In the arcuate nucleus of the hypothalamus reside two neuronal systems in charge of regulating feeding control and reproductive development. The melanocortin…”
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    Neurobeachin, a promising target for use in the treatment of alcohol use disorder by Cuzon Carlson, Verginia C., Aylwin, Carlos F., Carlson, Timothy L., Ford, Matthew, Mesnaoui, Houda, Lomniczi, Alejandro, Ferguson, Betsy, Cervera‐Juanes, Rita P.

    Published in Addiction biology (01-01-2022)
    “…Hazardous, heavy drinking increases risk for developing alcohol use disorder (AUD), which affects ~7% of adult Americans. Thus, understanding the molecular…”
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  12. 12

    Hypothalamic epigenetics driving female puberty by Toro, C. A., Aylwin, C. F., Lomniczi, A.

    Published in Journal of neuroendocrinology (01-07-2018)
    “…Puberty involves a series of morphological, physiological and behavioural changes during the last part of the juvenile period that culminates in the attainment…”
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