Search Results - "Aylwin, Carlos F"
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Trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty
Published in Nature communications (04-01-2018)“…Polycomb group (PcG) proteins control the timing of puberty by repressing the Kiss1 gene in hypothalamic arcuate nucleus (ARC) neurons. Here we identify two…”
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MKRN3 inhibits the reproductive axis through actions in kisspeptin-expressing neurons
Published in The Journal of clinical investigation (01-08-2020)“…The identification of loss-of-function mutations in MKRN3 in patients with central precocious puberty in association with the decrease in MKRN3 expression in…”
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Polycomb represses a gene network controlling puberty via modulation of histone demethylase Kdm6b expression
Published in Scientific reports (21-01-2021)“…Female puberty is subject to Polycomb Group (PcG)-dependent transcriptional repression. Kiss1 , a puberty-activating gene, is a key target of this silencing…”
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Sex-specific pubertal and metabolic regulation of Kiss1 neurons via Nhlh2
Published in eLife (08-09-2021)“…Hypothalamic Kiss1 neurons control gonadotropin-releasing hormone release through the secretion of kisspeptin. Kiss1 neurons serve as a nodal center that…”
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Kavalactones support motivation to move during intensive training in males preparing for military special operations forces
Published in Journal of the International Society of Sports Nutrition (01-12-2024)“…Military special operators, elite athletes, and others requiring uninterrupted optimal performance currently lack options for sleep and mood support without…”
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Characterization of SALL2 Gene Isoforms and Targets Across Cell Types Reveals Highly Conserved Networks
Published in Frontiers in genetics (22-02-2021)“…The SALL2 transcription factor, an evolutionarily conserved gene through vertebrates, is involved in normal development and neuronal differentiation. In…”
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Emerging Genetic and Epigenetic Mechanisms Underlying Pubertal Maturation in Adolescence
Published in Journal of research on adolescence (01-03-2019)“…The adolescent transition begins with the onset of puberty which, upstream in the brain, is initiated by the gonadotropin‐releasing hormone (GnRH) pulse…”
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Data on SVCT2 transporter expression and localization in cancer cell lines and tissues
Published in Data in brief (01-08-2019)“…The data presented in this article are related to the research paper entitled “Increased expression of mitochondrial sodium-coupled ascorbic acid transporter-2…”
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Sirtuin (SIRT)-1: At the crossroads of puberty and metabolism
Published in Current opinion in endocrine and metabolic research (01-10-2020)“…In the arcuate nucleus of the hypothalamus reside two neuronal systems in charge of regulating feeding control and reproductive development. The melanocortin…”
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Increased expression of mitochondrial sodium-coupled ascorbic acid transporter-2 (mitSVCT2) as a central feature in breast cancer
Published in Free radical biology & medicine (01-05-2019)“…The potential role of vitamin C in cancer prevention and treatment remains controversial. While normal human cells obtain vitamin C as ascorbic acid, the…”
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Neurobeachin, a promising target for use in the treatment of alcohol use disorder
Published in Addiction biology (01-01-2022)“…Hazardous, heavy drinking increases risk for developing alcohol use disorder (AUD), which affects ~7% of adult Americans. Thus, understanding the molecular…”
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Hypothalamic epigenetics driving female puberty
Published in Journal of neuroendocrinology (01-07-2018)“…Puberty involves a series of morphological, physiological and behavioural changes during the last part of the juvenile period that culminates in the attainment…”
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Kavalactones Promote Motivation To Expend Energy During Intensive Special Forces Prep Training: 1825
Published in Medicine and science in sports and exercise (01-09-2023)Get full text
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