Search Results - "Aykul, Senem"

Determination of half-maximal inhibitory concentration using biosensor-based protein interaction analysis by Aykul, Senem, Martinez-Hackert, Erik

“…Half-maximal inhibitory concentration (IC50) is the most widely used and informative measure of a drug's efficacy. It indicates how much drug is needed to…”
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BMP-4 Extraction from Extracellular Matrix and Analysis of Heparin-Binding Properties by Aykul, Senem, Maust, Jordan, Martinez-Hackert, Erik

“…Recombinant human BMP-4 growth factor (GF) has significant commercial potential as therapeutic for regenerating bone and as cell culture supplement. However,…”
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Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop by Aykul, Senem, Corpina, Richard A, Goebel, Erich J, Cunanan, Camille J, Dimitriou, Alexandra, Kim, Hyon Jong, Zhang, Qian, Rafique, Ashique, Leidich, Raymond, Wang, Xin, McClain, Joyce, Jimenez, Johanna, Nannuru, Kalyan C, Rothman, Nyanza J, Lees-Shepard, John B, Martinez-Hackert, Erik, Murphy, Andrew J, Thompson, Thomas B, Economides, Aris N, Idone, Vincent

“…Activin A functions in BMP signaling in two ways: it either engages ACVR1B to activate Smad2/3 signaling or binds ACVR1 to form a non-signaling complex (NSC)…”
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Smad2/3 Activation Regulates Smad1/5/8 Signaling via a Negative Feedback Loop to Inhibit 3T3-L1 Adipogenesis by Aykul, Senem, Maust, Jordan, Thamilselvan, Vijayalakshmi, Floer, Monique, Martinez-Hackert, Erik

“…Adipose tissues (AT) expand in response to energy surplus through adipocyte hypertrophy and hyperplasia. The latter, also known as adipogenesis, is a process…”
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Human Cerberus prevents nodal-receptor binding, inhibits nodal signaling, and suppresses nodal-mediated phenotypes by Aykul, Senem, Ni, Wendi, Mutatu, Washington, Martinez-Hackert, Erik

“…The Transforming Growth Factor-ß (TGFß) family ligand Nodal is an essential embryonic morphogen that is associated with progression of breast and other…”
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Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1 by Aykul, Senem, Huang, Lily, Wang, Lili, Das, Nanditha M, Reisman, Sandra, Ray, Yonaton, Zhang, Qian, Rothman, Nyanza, Nannuru, Kalyan C, Kamat, Vishal, Brydges, Susannah, Troncone, Luca, Johnsen, Laura, Yu, Paul B, Fazio, Sergio, Lees-Shepard, John, Schutz, Kevin, Murphy, Andrew J, Economides, Aris N, Idone, Vincent, Hatsell, Sarah J

“…Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder whose most debilitating pathology is progressive and cumulative heterotopic ossification…”
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Structural basis for potency differences between GDF8 and GDF11 by Walker, Ryan G, Czepnik, Magdalena, Goebel, Erich J, McCoy, Jason C, Vujic, Ana, Cho, Miook, Oh, Juhyun, Aykul, Senem, Walton, Kelly L, Schang, Gauthier, Bernard, Daniel J, Hinck, Andrew P, Harrison, Craig A, Martinez-Hackert, Erik, Wagers, Amy J, Lee, Richard T, Thompson, Thomas B

“…Growth/differentiation factor 8 (GDF8) and GDF11 are two highly similar members of the transforming growth factor β (TGFβ) family. While GDF8 has been…”
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How Activin A Became a Therapeutic Target in Fibrodysplasia Ossificans Progressiva by Srinivasan, Dushyanth, Arostegui, Martin, Goebel, Erich J, Hart, Kaitlin N, Aykul, Senem, Lees-Shepard, John B, Idone, Vincent, Hatsell, Sarah J, Economides, Aris N

“…Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by episodic yet cumulative heterotopic ossification (HO) of skeletal…”
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Substitutions of Conserved Residues in the C-terminal Region of DnaC Cause Thermolability in Helicase Loading by Felczak, Magdalena M., Sage, Jay M., Hupert-Kocurek, Katarzyna, Aykul, Senem, Kaguni, Jon M.

“…The DnaB-DnaC complex binds to the unwound DNA within the Escherichia coli replication origin in the helicase loading process, but the biochemical events that…”
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Transforming Growth Factor-β Family Ligands Can Function as Antagonists by Competing for Type II Receptor Binding by Aykul, Senem, Martinez-Hackert, Erik

“…Transforming growth factor-β (TGF-β) family ligands are pleiotropic cytokines. Their physiological activities are not determined by a simple coupling of…”
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New Ligand Binding Function of Human Cerberus and Role of Proteolytic Processing in Regulating Ligand–Receptor Interactions and Antagonist Activity by Aykul, Senem, Martinez-Hackert, Erik

“…Cerberus is a key regulator of vertebrate embryogenesis. Its biological function has been studied extensively in frog and mouse embryos. Its ability to bind…”
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High-Throughput, Biosensor-Based Approach to Examine Bone Morphogenetic Protein (BMP)-Receptor Interactions by Aykul, Senem, Martinez-Hackert, Erik

“…Binding of a BMP to its cognate cell surface receptors is the initiating step in the BMP signaling cascade. Thus, knowing which BMP-receptor complexes form is…”
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Biochemical and Cellular Analysis Reveals Ligand Binding Specificities, a Molecular Basis for Ligand Recognition, and Membrane Association-dependent Activities of Cripto-1 and Cryptic by Aykul, Senem, Parenti, Anthony, Chu, Kit Yee, Reske, Jake, Floer, Monique, Ralston, Amy, Martinez-Hackert, Erik

“…Transforming growth factor β (TGF-β) pathways are key determinants of cell fate in animals. Their basic mechanism of action is simple. However, to produce…”
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Activin E-ACVR1C cross talk controls energy storage via suppression of adipose lipolysis in mice by Adam, Rene C, Pryce, Dwaine S, Lee, Joseph S, Zhao, Yuanqi, Mintah, Ivory J, Min, Soo, Halasz, Gabor, Mastaitis, Jason, Atwal, Gurinder S, Aykul, Senem, Idone, Vincent, Economides, Aris N, Lotta, Luca A, Murphy, Andrew J, Yancopoulos, George D, Sleeman, Mark W, Gusarova, Viktoria

“…Body fat distribution is a heritable risk factor for cardiovascular and metabolic disease. In humans, rare Inhibin beta E ( , activin E) loss-of-function…”
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Anti-ACVRI antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressive by Aykul, Senem, Huang, Lily, Wang, Lili, Das, Nanditha M, Reisman, Sandra, Ray, Yonaton, Zhang, Qian, Rothman, Nyanza, Nannuru, Kalyan C, Brydges, Vishal KamaSusannah, Troncone, Luca, Johnsen, Laura, Yu, Paul B, Fazio, Sergio, Lees-Shepard, John, Schutz, Kevin, Murphy, Andrew J, Economides, Aris N, Idone, Vincent, Hatsell, Sarah J

“…Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder whose most debilitating pathology is progressive and cumulative heterotopic ossification…”
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Anti-ACVRI antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressive by activating FOP-mutant ACVR1 by Aykul, Senem, Huang, Lily, Wang, Lili, Das, Nanditha M, Reisman, Sandra, Ray, Yonaton, Zhang, Qian, Rothman, Nyanza, Nannuru, Kalyan C, Brydges, Vishal KamaSusannah, Troncone, Luca, Johnsen, Laura, Yu, Paul B, Fazio, Sergio, Lees-Shepard, John, Schutz, Kevin, Murphy, Andrew J, Economides, Aris N, Idone, Vincent, Hatsell, Sarah J

“…Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder whose most debilitating pathology is progressive and cumulative heterotopic ossification…”
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Dissecting the Extracellular Mechanisms of Nodal and Activin Signaling Regulation by Aykul, Senem

“…Transforming Growth Factor-beta (TGF-beta) family ligands are key regulators of multiple cellular processes including cell proliferation, differentiation, and…”
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