Search Results - "Ayissi Owona, Brice"

Natural compounds flavonoids as modulators of inflammasomes in chronic diseases by Owona, Brice Ayissi, Abia, Wilfred Angie, Moundipa, Paul Fewou

“…•Flavonoids are drawing attention due to their modulatory effects on inflammasomes.•Flavonoids may contribute to drug discovery by targeting…”
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Amelioration of Behavioral Impairments and Neuropathology by Antiepileptic Drug Topiramate in a Transgenic Alzheimer's Disease Model Mice, APP/PS1 by Owona, Brice Ayissi, Zug, Caroline, Schluesener, Hermann J, Zhang, Zhi-Yuan

“…Alzheimer's disease (AD) is a neurodegenerative disease that is the main cause of dementia in the elderly. The aggregation of β-amyloid peptides is one of the…”
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A fraction of stem bark extract of Entada africana suppresses lipopolysaccharide-induced inflammation in RAW 264.7 cells by Ayissi Owona, Brice, Njayou, Nico Frederic, Laufer, Stefan, Moundipa, Paul Fewou, Schluesener, Hermann J.

“…Entada africana is a plant used in African traditional medicine for the treatment of stomachache, fever, liver related diseases, wound healing, cataract and…”
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Inhibition of CYP2E1 and activation of Nrf2 signaling pathways by a fraction from Entada africana alleviate carbon tetrachloride-induced hepatotoxicity by Kouam, Arnaud Fondjo, Owona, Brice Ayissi, Fifen, Rodrigue, Njayou, Frédéric Nico, Moundipa, Paul Fewou

“…Entada africana is used in non-conventional medicine for the management of liver ailments. A fraction, designated EaF10 (methylene chloride/methanol 90:10,…”
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In Vitro and In Silico Potential Inhibitory Effects of New Biflavonoids from Ochna rhizomatosa on HIV-1 Integrase and Plasmodium falciparum by Messi, Angélique Nicolas, Bonnet, Susan Lucia, Owona, Brice Ayissi, Wilhelm, Anke, Kamto, Eutrophe Le Doux, Ndongo, Joseph Thierry, Siwe-Noundou, Xavier, Poka, Madan, Demana, Patrick H., Krause, Rui W. M., Ngo Mbing, Joséphine, Pegnyemb, Dieudonné Emmanuel, Bochet, Christian G.

“…The aim of this study was to identify bioactive secondary metabolites from Ochna rhizomatosa with potential inhibitory effects against HIV and Plasmodium…”
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Withaferin A modulates AIM2 inflammasome and caspase-1 expression in THP-1 polarized macrophages by Ngoungoure, Florence Pare, Owona, Brice Ayissi

“…Inflammasomes are cytoplasmic protein complexes that regulate the secretion of pro-inflammatory cytokines including IL-1β and IL18, thereby playing a crucial…”
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In silico and in vitro screening of licensed antimalarial drugs for repurposing as inhibitors of hepatitis E virus by Tietcheu Galani, Borris Rosnay, Ayissi Owona, Vincent Brice, Guemmogne Temdie, Romeo Joel, Metzger, Karoline, Atsama Amougou, Marie, Djamen Chuisseu, Pascal Dieudonné, Fondjo Kouam, Arnaud, Ngounoue Djuidje, Marceline, Aliouat-Denis, Cécile-Marie, Cocquerel, Laurence, Fewou Moundipa, Paul

“…Hepatitis E virus (HEV) infection is emerging in Cameroon and represents one of the most common causes of acute hepatitis and jaundice. Moreover, earlier…”
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Molecular Insight in the Multifunctional Effects of Oridonin by Owona, Brice Ayissi, Schluesener, Herman J.

“…Oridonin has attracted considerable attention in the last decade because of its anti-cancer pharmacological properties. This ent-kaurane diterpenoid, isolated…”
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Biflavonoid Methylchamaejasmin and Khaya grandifoliola Extract Inhibit NLRP3 Inflammasome in THP-1 Cell Model of Neuroinflammation by Owona, Brice Ayissi, Mary, Arnaud, Messi, Angelique N, Ravichandran, Kishore Aravind, Mbing, Josephine Ngo, Pegnyemb, Emmanuel, Moundipa, Paul F, Heneka, Michael T

“…Neuroinflammation is a common hallmark of Alzheimer's disease (AD), with NLRP3 inflammasome proven to be activated in microglia of AD patients' brains. In this…”
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Protective Effects of Forskolin on Behavioral Deficits and Neuropathological Changes in a Mouse Model of Cerebral Amyloidosis by Owona, Brice Ayissi, Zug, Caroline, Schluesener, Hermann J., Zhang, Zhi-Yuan

“…The production of amyloid-β peptides in the brains of patients with Alzheimer disease (AD) may contribute to memory loss and impairments in social behavior…”
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Insights into the inhibition mechanisms of MERS-CoV and SARS-CoV2 papain-like proteases by inhibitors from Crinum distichum: In vitro and in silico analysis by Kouam, Arnaud Fondjo, Mabou, Florence Déclaire, Fu, Lifeng, Koagne, Roméol Romain, Li, Yan, Owona, Brice Ayissi, Zeuko'o, Elisabeth Menkem, Fepa, Armelle Gaelle Kwesseu, Galani, Borris Rosnay Tietcheu, Reyes, Fernando, Njayou, Frédéric Nico, Moundipa, Paul Fewou, Gao, George Fu

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Khaya grandifoliola active fraction as a source of therapeutic compounds for Alzheimer’s disease treatment: In silico validation of identified compounds by Owona, Brice Ayissi, Njayou, Frederic N., Mkounga, Pierre, Moundipa, Paul F.

“…Overproduction of Nitric oxide (NO) and many other pro-inflammatory mediators are responsible for many pathological disorders in humans, including Alzheimer’s…”
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In Vitro and In Silico Potential Inhibitory Effects of New Biflavonoids from IOchna rhizomatosa/I on HIV-1 Integrase and IPlasmodium falciparum/I by Messi, Angélique Nicolas, Bonnet, Susan Lucia, Owona, Brice Ayissi, Wilhelm, Anke, Kamto, Eutrophe Le Doux, Ndongo, Joseph Thierry, Siwe-Noundou, Xavier, Poka, Madan, Demana, Patrick H, Krause, Rui W. M, Ngo Mbing, Joséphine, Pegnyemb, Dieudonné Emmanuel, Bochet, Christian G

“…The aim of this study was to identify bioactive secondary metabolites from Ochna rhizomatosa with potential inhibitory effects against HIV and Plasmodium…”
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Crimean Congo hemorrhagic fever virus exposure among febrile patients, cattle herders, and cattle herds in Cameroon by Simo, Fredy Brice Nemg, Teagho, Urmes Chantale Sobjio, Atako, Serika Marshall, Lontsi, Brice Tiwa, Owona, Brice Vincent Ayissi, Demanou, Maurice, Wondji, Charles Sinclair, Kamgang, Basile, Burt, Felicity Jane, Ryan, Sadie J., Makoah, Nigel Aminake, Dinglasan, Rhoel R., Moundipa, Paul Fewou

“…•Data on CCHFV prevalence are needed for comprehensive surveillance and preventive measures.•Despite high tick knowledge, herders lack understanding of…”
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Entada africana fraction CH₂Cl₂/MEOH 5% inhibits inducible nitric oxide synthase and pro-inflammatory cytokines gene expression induced by lipopolysaccharide in microglia by Owona, Brice Ayissi, Njayou, Nico Frederic, Laufer, Stefan A, Schluesener, Hermann J, Moundipa, Paul Fewou

“…Inflammatory response in the CNS mediated by microglia cells play an important role in host defense and is implicated in the pathology of neurodegenerative…”
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Entada africana fraction CH sub(2)Cl sub(2)/MEOH 5% inhibits inducible nitric oxide synthase and pro-inflammatory cytokines gene expression induced by lipopolysaccharide in microglia by Owona, Brice Ayissi, Njayou, Nico Frederic, Laufer, Stefan A, Schluesener, Hermann J, Moundipa, Paul Fewou

“…Background: Inflammatory response in the CNS mediated by microglia cells play an important role in host defense and is implicated in the pathology of…”
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Entada africana fraction CH2 Cl2 /MEOH 5% inhibits inducible nitric oxide synthase and pro-inflammatory cytokines gene expression induced by lipopolysaccharide in microglia by Owona, Brice Ayissi, Njayou, Nico Frederic, Laufer, Stefan A, Schluesener, Hermann J, Moundipa, Paul Fewou

“…Doc number: 254 Abstract Background: Inflammatory response in the CNS mediated by microglia cells play an important role in host defense and is implicated in…”
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