Search Results - "Ayinuola, Yetunde A"

Inactivation of the lysine binding sites of human plasminogen (hPg) reveals novel structural requirements for the tight hPg conformation, M-protein binding, and rapid activation by Ayinuola, Yetunde A, Castellino, Francis J

“…Accelerated activation of the human plasminogen zymogen (hPg) to two-chain active plasmin (hPm) is achieved following conformational changes induced by…”
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The M Protein of Streptococcus pyogenes Strain AP53 Retains Cell Surface Functional Plasminogen Binding after Inactivation of the Sortase A Gene by Russo, Brady T, Ayinuola, Yetunde A, Singh, Damini, Carothers, Katelyn, Fischetti, Vincent A, Flores-Mireles, Ana L, Lee, Shaun W, Ploplis, Victoria A, Liang, Zhong, Castellino, Francis J

“…(Lancefield group A [GAS]) is a β-hemolytic human-selective pathogen that is responsible for a large number of morbid and mortal infections in humans. For…”
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Relationships Between Plasminogen-Binding M-Protein and Surface Enolase for Human Plasminogen Acquisition and Activation in Streptococcus pyogenes by Ayinuola, Yetunde A, Tjia-Fleck, Sheiny, Readnour, Bradley M, Liang, Zhong, Ayinuola, Olawole, Paul, Lake N, Lee, Shaun W, Fischetti, Vincent A, Ploplis, Victoria A, Castellino, Francis J

“…The proteolytic activity of human plasmin (hPm) is utilized by various cells to provide a surface protease that increases the potential of cells to migrate and…”
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Plasminogen missense variants and their involvement in cardiovascular and inflammatory disease by Brito-Robinson, Teresa, Ayinuola, Yetunde A, Ploplis, Victoria A, Castellino, Francis J

“…Human plasminogen (PLG), the zymogen of the fibrinolytic protease, plasmin, is a polymorphic protein with two widely distributed codominant alleles, PLG/Asp…”
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Binding of the kringle‐2 domain of human plasminogen to streptococcal PAM‐type M‐protein causes dissociation of PAM dimers by Ayinuola, Olawole, Ayinuola, Yetunde A., Qiu, Cunjia, Lee, Shaun W., Ploplis, Victoria A., Castellino, Francis J.

“…The direct binding of human plasminogen (hPg), via its kringle‐2 domain (K2hPg), to streptococcal M‐protein (PAM), largely contributes to the pathogenesis of…”
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Group A Streptococcus- Induced Activation of Human Plasminogen Is Required for Keratinocyte Wound Retraction and Rapid Clot Dissolution by Vu, Henry M, Hammers, Daniel E, Liang, Zhong, Nguyen, Gabrielle L, Benz, Mary E, Moran, Thomas E, Higashi, Dustin L, Park, Claudia J, Ayinuola, Yetunde A, Donahue, Deborah L, Flores-Mireles, Ana L, Ploplis, Victoria A, Castellino, Francis J, Lee, Shaun W

“…Invasive outcomes of Group A (GAS) infections that involve damage to skin and other tissues are initiated when these bacteria colonize and disseminate an open…”
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High-Resolution Single-Particle Cryo-EM Hydrated Structure of Streptococcus pyogenes Enolase Offers Insights into Its Function as a Plasminogen Receptor by Tjia-Fleck, Sheiny, Readnour, Bradley M., Ayinuola, Yetunde A., Castellino, Francis J.

“…Cellular plasminogen (Pg) receptors (PgRs) are utilized to recruit Pg; stimulate its activation to the serine protease, plasmin (Pm); and sterically protect…”
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Generation and characterization of a plasminogen-binding group A streptococcal M-protein/streptokinase-sensitive mouse line by Ayinuola, Yetunde A., Donahue, Deborah L., Charles, Jermilia, Liang, Zhong, Castellino, Francis J., Ploplis, Victoria A.

“…Streptococcus pyogenes (GAS) is a human bacterial pathogen that generates various mild to severe diseases. Worldwide, there are approximately 700 million cases…”
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Evolution of Streptococcus pyogenes has maximized the efficiency of the Sortase A cleavage motif for cell wall transpeptidation by Readnour, Bradley M., Ayinuola, Yetunde A., Russo, Brady T., Liang, Zhong, Lee, Shaun W., Ploplis, Victoria A., Fischetti, Vincent A., Castellino, Francis J.

“…Trafficking of M-protein (Mprt) from the cytosol of Group A Streptococcus pyogenes (GAS) occurs via Sec translocase membrane channels that associate with…”
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Streptococcus co-opts a conformational lock in human plasminogen to facilitate streptokinase cleavage and bacterial virulence by Ayinuola, Yetunde A., Brito-Robinson, Teresa, Ayinuola, Olawole, Beck, Julia E., Cruz-Topete, Diana, Lee, Shaun W., Ploplis, Victoria A., Castellino, Francis J.

“…Virulent strains of Streptococcus pyogenes (gram-positive group A Streptococcus pyogenes [GAS]) recruit host single-chain human plasminogen (hPg) to the cell…”
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Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes by Yuan, Yue, Ayinuola, Yetunde A., Singh, Damini, Ayinuola, Olawole, Mayfield, Jeffrey A., Quek, Adam, Whisstock, James C., Law, Ruby H.P., Lee, Shaun W., Ploplis, Victoria A., Castellino, Francis J.

“…[Display omitted] •Solution structural determination by high-resolution NMR of the A-domain of PAM reveals occupancy by two molecules of K2hPg on opposite…”
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Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding by Quek, Adam J.H., Mazzitelli, Blake A., Wu, Guojie, Leung, Eleanor W.W., Caradoc-Davies, Tom T., Lloyd, Gordon J., Jeevarajah, Devadharshini, Conroy, Paul J., Sanderson-Smith, Martina, Yuan, Yue, Ayinuola, Yetunde A., Castellino, Francis J., Whisstock, James C., Law, Ruby H.P.

“…Plasminogen (Plg)-binding M protein (PAM) is a group A streptococcal cell surface receptor that is crucial for bacterial virulence. Previous studies revealed…”
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