Search Results - "Ayi, Kodjo"

Rocaglates as dual-targeting agents for experimental cerebral malaria by Langlais, David, Cencic, Regina, Moradin, Neda, Kennedy, James M., Ayi, Kodjo, Brown, Lauren E., Crandall, Ian, Tarry, Michael J., Schmeing, Martin, Kain, Kevin C., Porco, John A., Pelletier, Jerry, Gros, Philippe

“…Cerebral malaria (CM) is a severe and rapidly progressing complication of infection by Plasmodium parasites that is associated with high rates of mortality and…”
Get full text

Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria by Crowley, Valerie M, Ayi, Kodjo, Lu, Ziyue, Liby, Karen T, Sporn, Michael, Kain, Kevin C

“…Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection associated with high mortality and neurocognitive impairment in survivors…”
Get full text

C5 deficiency and C5a or C5aR blockade protects against cerebral malaria by Patel, Samir N, Berghout, Joanne, Lovegrove, Fiona E, Ayi, Kodjo, Conroy, Andrea, Serghides, Lena, Min-oo, Gundula, Gowda, D Channe, Sarma, J Vidya, Rittirsch, Daniel, Ward, Peter A, Liles, W Conrad, Gros, Philippe, Kain, Kevin C

“…Experimental infection of mice with Plasmodium berghei ANKA (PbA) provides a powerful model to define genetic determinants that regulate the development of…”
Get full text

ABO blood groups influence macrophage-mediated phagocytosis of Plasmodium falciparum-infected erythrocytes by Wolofsky, Kayla T, Ayi, Kodjo, Branch, Donald R, Hult, Annika K, Olsson, Martin L, Liles, W Conrad, Cserti-Gazdewich, Christine M, Kain, Kevin C

“…Erythrocyte polymorphisms associated with a survival advantage to Plasmodium falciparum infection have undergone positive selection. There is a predominance of…”
Get full text

HIV impairs opsonic phagocytic clearance of pregnancy-associated malaria parasites by KEEN, J, SERGHIDES, L, AYI, K, PATEL, S.N, AYISI, J, VAN EIJK, A, STEKETEE, R, UDHAYAKUMAR, V, KAIN, K.C

“…Primigravid (PG) women are at risk for pregnancy-associated malaria (PAM). Multigravid (MG) women acquire protection against PAM; however, HIV infection…”
Get full text

Characterization of a new phosphatase from Plasmodium by Hills, Tanya, Srivastava, Anubhav, Ayi, Kodjo, Wernimont, Amy K., Kain, Kevin, Waters, Andrew P., Hui, Raymond, Pizarro, Juan C.

“…[Display omitted] ► Plasmodium genome encodes for a second phosphoglycerate mutase (PGM2). ► PfPGM2 has a PGM fold with phosphatase activity. ► PGM2 is…”
Get full text

16α-Bromoepiandrosterone, an Antimalarial Analogue of the Hormone Dehydroepiandrosterone, Enhances Phagocytosis of Ring Stage Parasitized Erythrocytes: a Novel Mechanism for Antimalarial Activity by AYI, Kodjo, GIRIBALDI, Giuliana, SKOROKHOD, Aleksei, SCHWARZER, Evelin, PRENDERGAST, Patrick T, ARESE, Paolo

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Nonopsonic Phagocytosis of Erythrocytes Infected with Ring-Stage Plasmodium falciparum by Ayi, Kodjo, Patel, Samir N, Serghides, Lena, Smith, Todd G, Kain, Kevin C

“…Ring-stage parasitized erythrocytes (RPEs) were demonstrated to interact with effector cells of the innate immune system. With receptor blockade studies and…”
Get full text

Enhanced phagocytosis of ring-parasitized mutant erythrocytes: a common mechanism that may explain protection against falciparum malaria in sickle trait and beta-thalassemia trait by Ayi, Kodjo, Turrini, Franco, Piga, Antonio, Arese, Paolo

“…High frequency of erythrocyte (red blood cell [RBC]) genetic disorders such as sickle cell trait, thalassemia trait, homozygous hemoglobin C (Hb-C), and…”
Get full text

CD47-SIRPα Interactions Regulate Macrophage Uptake of Plasmodium falciparum-Infected Erythrocytes and Clearance of Malaria In Vivo by Ayi, Kodjo, Lu, Ziyue, Serghides, Lena, Ho, Jenny M, Finney, Constance, Wang, Jean C Y, Liles, W Conrad, Kain, Kevin C

“…CD47 engagement by the macrophage signal regulatory protein alpha (SIRPα) inhibits phagocytic activity and protects red blood cells (RBCs) from…”
Get full text

Pyruvate Kinase Deficiency and Malaria by Ayi, Kodjo, Min-Oo, Gundula, Serghides, Lena, Crockett, Maryanne, Kirby-Allen, Melanie, Quirt, Ian, Gros, Philippe, Kain, Kevin C

“…Erythrocytes from patients with pyruvate kinase deficiency are resistant to invasion by Plasmodium falciparum . Such erythrocytes that succumb to infection are…”
Get full text

HIV Infection Deregulates Tim-3 Expression on Innate Cells: Combination Antiretroviral Therapy Results in Partial Restoration by Finney, Constance A.M, Ayi, Kodjo, Wasmuth, James D, Sheth, Prameet M, Kaul, Rupert, Loutfy, Mona, Kain, Kevin C, Serghides, Lena

“…BACKGROUND:The Tim-3 receptor has been implicated as a negative regulator of adaptive immune responses and has been linked to T-cell dysfunction in chronic…”
Get full text

Chronic HIV Infection Impairs Nonopsonic Phagocytosis of Malaria Parasites by Serghides, Lena, Finney, Constance A M, Ayi, Kodjo, Loutfy, Mona, Kain, Kevin C

“…Malaria-specific immune responses are altered in HIV/malaria-coinfected individuals and are associated with higher parasite burdens and more severe clinical…”
Get full text

Disruption of CD36 Impairs Cytokine Response to Plasmodium falciparum Glycosylphosphatidylinositol and Confers Susceptibility to Severe and Fatal Malaria In Vivo by Patel, Samir N, Lu, Ziyue, Ayi, Kodjo, Serghides, Lena, Gowda, D. Channe, Kain, Kevin C

“…CD36 is a scavenger receptor that has been implicated in malaria pathogenesis as well as innate defense against blood-stage infection. Inflammatory responses…”
Get full text

Rosiglitazone Modulates the Innate Immune Response to Plasmodium falciparum Infection and Improves Outcome in Experimental Cerebral Malaria by Serghides, Lena, Patel, Samir N., Ayi, Kodjo, Lu, Ziyue, Gowda, D. Channe, Liles, W. Conrad, Kain, Kevin C.

“…For severe malarial syndromes such as cerebral malaria, adverse clinical outcomes are often mediated by the immune system rather than caused by the parasite…”
Get full text

Hemolytic anemia induced by ribavirin therapy in patients with chronic hepatitis C virus infection: Role of membrane oxidative damage by De Franceschi, Lucia, Fattovich, Giovanna, Turrini, Franco, Ayi, Kodjo, Brugnara, Carlo, Manzato, Franco, Noventa, Franco, Stanzial, Anna Maria, Solero, Pietro, Corrocher, Roberto

“…The antiviral drug ribavirin (RBV) is widely used in combination with interferon (IFN) in the treatment of chronic hepatitis C virus (HCV) infection. A major…”
Get full text

Adenosine Triphosphate Depletion of Erythrocytes Simulates the Phenotype Associated with Pyruvate Kinase Deficiency and Confers Protection against Plasmodium falciparum In Vitro by Ayi, Kodjo, Liles, W. Conrad, Gros, Philippe, Kain, Kevin C.

“…BackgroundErythrocytes from individuals with pyruvate kinase deficiency (PKD) are resistant to invasion by Plasmodium falciparum parasites, and erythrocytes…”
Get full text

HIV infection deregulates innate immunity to malaria despite combination antiretroviral therapy by FINNEY, Constance A. M, AYI, Kodjo, WASMUTH, James D, SHETH, Prameet M, KAUL, Rupert, LOUTFY, Mona R, KAIN, Kevin C, SERGHIDES, Lena

“…Malaria and HIV-1 adversely interact, with HIV-positive individuals suffering higher parasite burdens and worse clinical outcomes. However, the mechanisms…”
Get full text

Cysteamine, the natural metabolite of pantetheinase, shows specific activity against Plasmodium by Min-Oo, Gundula, Ayi, Kodjo, Bongfen, Silayuv E., Tam, Mifong, Radovanovic, Irena, Gauthier, Susan, Santiago, Helton, Rothfuchs, Antonio Gigliotti, Roffê, Ester, Sher, Alan, Mullick, Alaka, Fortin, Anny, Stevenson, Mary M., Kain, Kevin C., Gros, Philippe

“…In mice, loss of pantetheinase activity causes susceptibility to infection with Plasmodium chabaudi AS. Treatment of mice with the pantetheinase metabolite…”
Get full text

Rosiglitazone modulates innate immune responses to Plasmodium falciparum and improves outcome in experimental cerebral malaria by Serghides, Lena, Patel, Samir N., Ayi, Kodjo, Lu, Ziyue, Gowda, D. Channe, Liles, W. Conrad, Kain, Kevin C.

“…For severe malarial syndromes such as cerebral malaria, adverse clinical outcomes are often immune-mediated rather than caused by the parasite directly;…”
Get full text