Search Results - "Ayhan, Aysel"
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A novel mechanism of ACE inhibition–associated enhanced platelet reactivity: disproof of the ARB-MI paradox?
Published in European journal of clinical pharmacology (01-09-2020)“…Purpose ACE inhibitors (ACEI) and angiotensin II receptor blockers (ARB) are important drugs in cardiovascular disease. However, little is known about which of…”
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Only Acute but Not Chronic Thrombocytopenia Protects Mice against Left Ventricular Dysfunction after Acute Myocardial Infarction
Published in Cells (Basel, Switzerland) (01-11-2022)“…Platelets are major players of thrombosis and inflammation after acute myocardial infarction (AMI). The impact of thrombocytopenia on platelet-induced cellular…”
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Sphingosine‐1‐phosphate improves outcome of no‐reflow acute myocardial infarction via sphingosine‐1‐phosphate receptor 1
Published in ESC Heart Failure (01-02-2023)“…Aims Therapeutic options targeting post‐ischaemic cardiac remodelling are sparse. The bioactive sphingolipid sphingosine‐1‐phosphate (S1P) reduces…”
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Endothelial β1 Integrin-Mediated Adaptation to Myocardial Ischemia
Published in Thrombosis and haemostasis (01-06-2021)“…Short episodes of myocardial ischemia can protect from myocardial infarction. However, the role of endothelial β1 integrin in these cardioprotective ischemic…”
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Rivaroxaban Reduces Arterial Thrombosis by Inhibition of FXa-Driven Platelet Activation via Protease Activated Receptor-1
Published in Circulation research (14-02-2020)“…A reduced rate of myocardial infarction has been reported in patients with atrial fibrillation treated with FXa (factor Xa) inhibitors including rivaroxaban…”
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Phenyl Bis-Sulfonamide Keap1-Nrf2 Protein–Protein Interaction Inhibitors with an Alternative Binding Mode
Published in Journal of medicinal chemistry (26-05-2022)“…Inhibitors of Kelch-like ECH-associated protein 1 (Keap1) increase the activity of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2)…”
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Platelet reactivity is higher in e-cigarette vaping as compared to traditional smoking
Published in International journal of cardiology (15-11-2021)“…Vaping emerges as alternative to standard tobacco smoking. However, there is evidence for critical cardiovascular, gastrointestinal and respiratory side…”
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MTX Treatment Does Not Improve Outcome in Mice with AMI
Published in Pharmacology (01-03-2021)“…Targeting inflammation in patients with coronary artery disease and/or acute myocardial infarction (AMI) is a matter of debate. Methotrexate (MTX) is one of…”
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